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Filtering by: Creator Gharib, Camron I. Degree Field Biochemistry and Biophysics Degree Name Doctor of Philosophy (Ph.D.)

Mitochondrial decay in the aging rat heart : changes in fatty acid-supported bioenergetics and macromolecular organization of the electron transport system

Creator:

Gómez Ramirez, Luis A.

Abstract:

Decline in cardiac pump function is a hallmark of aging where mitochondrial decay is an important underlying cause. Although certainly multifactorial in nature, both dysfunction of the machinery involved in the chemiosmotic process of energy transduction and lower capacity to maintain fatty acid-driven respiration are identified as intrinsic factors of...

Resource Type:

Dissertation

Full Text:

supercomplexes comprised of various stoichiometries of complexes I, III and IV (never complex II), which
Antioxidant mechanisms of ascorbate and (R)-α-lipoic acid in aging and transition metal ion-mediated oxidative stress

Creator:

Shu, Jung Hyuk

Abstract:

Oxidative stress is the major driving force behind the aging process and many age-related diseases. However, direct experimental evidence of whether antioxidants, such as ascorbate (AA) and lipoic acid (LA) can slow the progression of aging process and/or reduce risks of developing degenerative disease is largely absent. This suggests a...

Resource Type:

Dissertation

Full Text:

AN ABSTRACT OF THE DISSERTATION OF Jung I-Iyuk Suh for the