Index Catalog // ScholarsArchive@OSU

Structural studies of the antioxidant defense enzymes; copper, zinc superoxide dismutase and alkyl hydroperoxide reductase flavoprotein

Creator:: Roberts, Blaine R.
Abstract:: Oxygen derived radicals are involved in many aspects of life from aging and cell signaling to disease states as diverse as heart disease, diabetes, neurodegeneration and inflammation. Therefore, understanding the function of antioxidant defense proteins and the effects of oxygen derived radicals on protein function is essential to elucidate the...
Resource Type:: Dissertation
Full Text:: X-ray crystallographic structure and biochemical properties of two antioxidant defense enzymes

Modeling protein structure at atomic resolution

Creator:: Berkholz, Donald S.
Abstract:: This thesis includes three studies involving different aspects of modeling protein structure. The first study illustrates the levels of insight available from atomic-resolution protein structures. The second study derives general trends of protein geometry from atomic-resolution structures and shows their implications for modeling. The third study creates a model of...
Resource Type:: Dissertation
Full Text:: ....................................................................... 31 Protein expression, purification, and crystallization.............. 31 X-ray data collection and

Helical propensity of amino acids changes with solvent environment

Creator:: Krittanai, Chartchai
Resource Type:: Dissertation
Full Text:: using statistical calculation Redacted for Privacy from the X-ray crystallography database. It

Some physical studies on ribonuclease-S and its component parts, S-protein and S-peptide

Creator:: Tiffany, Thomas Oliver
Resource Type:: Dissertation
Full Text:: residues as determined from the X-ray 0 data of ribonuclease-S at 3. 5 A resolution. Therefore

A double-stranded secondary structure for hyaluronic acid in aqueous-organic solvent as revealed by vacuum ultraviolet circular dichroism

Creator:: Staskus, Paul
Abstract:: The association of hyaluronic acid (HA) into a double stranded structure has been investigated by circular dichroism (CD) spectroscopy into the vacuum ultraviolet region. The CD of HA changes dramatically, monitoring a cooperative transition as the dielectric constant of an aqueous solution is reduced by adding organic solvents. This structural...
Resource Type:: Dissertation
Full Text:: model building studies of the polymer performed to explain the origins of x-ray fiber diffraction

Structural investigations to understand the mechanisms of two proteins involved in sulfur chemistry : SsuE and cysteine dioxygenase

Creator:: Driggers, Camden McCullough
Abstract:: Sulfur is one of the six elements required during the early stages of the evolution of life, and enzymes involved in sulfur transfer and oxidation are increasingly being recognized as potential drug targets for antimicrobials as well as for therapies for cancer, neurodegenerative and inflammatory diseases. Bacteria are able to...
Resource Type:: Dissertation
Full Text:: ................................................................................... 69 Laboratory X-ray source control data sets

Functional, structural and evolutionary analyses of the ferritin-like superfamily of proteins

Creator:: Cooley, Richard Bleier
Abstract:: The ferritin-like superfamily (FLSF) of proteins is composed of a wide variety of functionally diverse proteins involved in oxygen dependent metal-mediated electron transfer reactions. Their biological importance is exemplified by the fact FLSF proteins are found in almost every organism from all three domains of life. Their functions range from...
Resource Type:: Dissertation
Full Text:: monumental understatement. I love you. CONTRIBUTION OF AUTHORS Bradley Dubbels contributed to

Functional and Structural Analyses of Three Distinct proteins by Biochemical and Biophysical Techniques

Creator:: Codding, Sara Jone
Abstract:: The focus of this dissertation was to understand protein function and structure ona molecular level. To do this successfully, a variety of biochemical and biophysicaltechniques were employed. A wide variety of techniques were applied to study theproteins of interest in this dissertation to probe protein-protein interactions, proteinfunction, protein structure, and...
Resource Type:: Dissertation
Full Text:: ...........................................................................................56 Expression, purification, and crystallization of ValA ................................56 X-ray

Bacteriophage T4-coded dihydrofolate reductase : cloning and structural analysis of its gene and organization of flanking regions

Creator:: Purohit, Sarla
Abstract:: The dihydrofolate reductase gene of bacteriophate T4 has been investigated at the structural level to elucide the unusual regulation of expression of this gene and possible evolutionary relationships between the ohage and drug resistance factors-encoded dihydrofolate reductases (DHFR). A 1.1-kilobase-pair restriction fragment of the T4 multiple mutant dec8 containing frd,...
Resource Type:: Dissertation
Full Text:: ternary complex (75) have been determined by X-Ray crystallography. Interestingly, irrespective of the

The binding of ethidium bromide to chromatin : model for carcinogen interactions

Creator:: McMurray, Cynthia T.
Abstract:: Five forms of chromatin, which represent the in vivo folded forms of nucleic acid, were isolated and used as the binding substrate for model intercalating compound, ethidium bromide. For all forms of chromatin, the affinity, location and structural effects of binding were examined. On the level of the nucleosome, the...
Resource Type:: Dissertation
Full Text:: gaps that are free of core histones (Mirzabekov, 1980). X-ray crystallography (Finch and Klug, 1976

ScholarsArchive@OSU

Structural studies of the antioxidant defense enzymes; copper, zinc superoxide dismutase and alkyl hydroperoxide reductase flavoprotein

Modeling protein structure at atomic resolution

Helical propensity of amino acids changes with solvent environment

Some physical studies on ribonuclease-S and its component parts, S-protein and S-peptide

A double-stranded secondary structure for hyaluronic acid in aqueous-organic solvent as revealed by vacuum ultraviolet circular dichroism

Structural investigations to understand the mechanisms of two proteins involved in sulfur chemistry : SsuE and cysteine dioxygenase

Functional, structural and evolutionary analyses of the ferritin-like superfamily of proteins

Functional and Structural Analyses of Three Distinct proteins by Biochemical and Biophysical Techniques

Bacteriophage T4-coded dihydrofolate reductase : cloning and structural analysis of its gene and organization of flanking regions

The binding of ethidium bromide to chromatin : model for carcinogen interactions

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