Index Catalog // ScholarsArchive@OSU

Impaired epidermal homeostasis in Bcl11bR3S/R3S homozygous mutant mice

Creator:: Kelly, Avalon G.
Abstract:: BCL11B, also known as CTIP2, is a transcription factor which plays a critical role in the regulation and development of many tissues and organ systems, including the skin. A 2019 study by Goos et. al. uncovered a novel point mutation in BCL11B gene that converted the Arginine(R)-3 residue to a...
Resource Type:: Honors College Thesis
Full Text:: G2/M phase and disruption of chromosomal stability (Satrimafitrah et al., 2016). Homologous domains

Thermodynamic Design Principles for Double-Strand Displacement microRNA Biosensors

Creator:: Smith, Natasha M.
Abstract:: In recent years, microRNA’s (miRNA’s) have emerged as important in regulating gene expression. Fluctuations in their levels are associated with the up or down-regulation of tumor-suppressor genes and oncogenes. Thus, the ability to visualize changes in miRNA is an important step in understanding cancer emergence and development. The Burrows group...
Resource Type:: Honors College Thesis
Full Text:: : _____________________________________________________ Sean M. Burrows In recent years, microRNA’s (miRNA’s) have

An Accumulation of Senescent Cells May Contribute to Chronic Inflammation of the Mammalian Liver

Creator:: Sugiyama, Aaron
Abstract:: The aging process is a biological phenomenon in mammals that heavily contributes to the onset of chronic diseases. While there are many theories that attempt to explain the biological onset of aging, one emerging theory involves chronic inflammation. Chronic inflammation has been previously linked to several age-related diseases and is...
Resource Type:: Honors College Thesis
Full Text:: ., Partridge, L., Serrano, M. & Kroemer, G. The Hallmarks of Aging.Cell 153, 1194–1217 (2013). 19

Quantification of Lipoic Acid InducedChanges in Nrf2-Mediated Stress Response

Creator:: Hobbs, Helen T.
Abstract:: As organisms age they lose the ability to respond to both exogenous and endogenous stresses, therefore placing them at a greater risk for the development of many diseases. The transcription factor Nrf2 is responsible for the induction of many oxidative stress response genes and therefore 3proteins. Additionally, Nrf2-mediated stress response...
Resource Type:: Honors College Thesis
Full Text:: 3. 1 3 5 0.0 0.5 1.0 1.5 Placebo Lipoic Acid Days on Supplement G C L C m R N A R e

Involvement of PP6 in Dephosphorylation of Bcl11b, a Tumor Suppressor Transcription Factor

Creator:: Parker, Chelsea R.
Abstract:: The purpose of this honors thesis research project is to investigate the molecular causes of childhood and infant T-cell acute lymphoblastic leukemias. T-cells are the work horses of the immune system, and like any organ, must develop properly to be fully functional. Improper development of thymocytes into T-cells can lead...
Resource Type:: Honors College Thesis
Full Text:: : _________________________________________ Theresa M. Filtz The purpose of this honors thesis research project is to investigate the

Activation and Nuclear Translocation of the Transcription Factor Nrf2 by the MAP Kinase Family

Creator:: Nguyen, Ngan H.
Abstract:: Eukaryotic cells have developed elaborate biochemical processes to counteract oxidative stress, electrophiles, or carcinogens due to environmental insults. One of these important cellular defense mechanisms is mediated by the transcription factor Nrf2 that have been shown to have decrease activity with age. While the process of which Nrf2 is involved...
Resource Type:: Honors College Thesis
Full Text:: ., Katoh, Y., Yamamoto, M., Talalay, P. (2002). Direct evidence that sulfhydryl groups of Keap1 are the

Voluntary alcohol consumption in male rhesus macaques suppresses cancellous bone remodeling

Creator:: Kahler-Quesada, Arianna M.
Abstract:: Background: Chronic heavy alcohol consumption is a risk factor for bone fracture. Using a non-human primate model of voluntary alcohol self-administration, we have recently shown that alcohol consumption suppresses intracortical bone remodeling. The current study extends this investigation to asses the effect of alcohol consumption on cancellous bone mass, architecture,...
Resource Type:: Honors College Thesis
Full Text:: K, Ozen S, Inan M, Baysal T, Guner G, Bora A (2002) Fracture healing and bone mass in rats fed on

Investigation of the roles of viral proteinases in the vaccinia virus life cycle

Creator:: Page, Jessica M.
Abstract:: An inducible, mutant virus, designated vvtetO:I7L/G1L, was used to study the morphogenic proteolysis step of the vaccinia virus life cycle. The vvtetO:I7L/G1L controlled the expression of two genes, I7L, a cysteine proteinase, and G1L, a putative metalloproteinase. These proteins are involved in the maturation of viral core proteins, p4a, p4b,...
Resource Type:: Honors College Thesis
Full Text:: THESIS OF Jessica M. Page for the degree of Honors Baccalaureate of Science in Biochemistry and

The role of CYP2E1 and CYP4A in the development of non-alcoholic steatohepatitis

Creator:: Hawkins, Jenna M.
Abstract:: Non-alcoholic Steatohepatitis (NASH) is an emerging form of liver disease associated with obesity, type II diabetes and dyslipidemia. As the prevalence of these metabolic conditions increases, so too has the occurrence of NASH in all sectors of the population. The pathology of this disease is similar to its alcoholic form,...
Resource Type:: Honors College Thesis
Full Text:: (F) 7 Liver KO-aged (M) 8 Liver KO-aged (F) nm ol /m in /m g 21 PNP Assay

Comparing 26S Proteasome Efficiency Between Long-Living and Short-Living Rodents

Creator:: Bradley, Lynda M.
Abstract:: Many people die yearly worldwide due to diseases associated with aging, and if the process of aging in humans was more understood, the health of these patients could be improved. While many biochemical actions are involved with the aging process, loss of proteostasis has been called one of the most...
Resource Type:: Honors College Thesis
Full Text:: Dantuma, N. P., Lindsten, K., Glas, R., Jellne, M., & Masucci, M. G. (2000). Short-lived green

ScholarsArchive@OSU

Impaired epidermal homeostasis in Bcl11bR3S/R3S homozygous mutant mice

Thermodynamic Design Principles for Double-Strand Displacement microRNA Biosensors

An Accumulation of Senescent Cells May Contribute to Chronic Inflammation of the Mammalian Liver

Quantification of Lipoic Acid InducedChanges in Nrf2-Mediated Stress Response

Involvement of PP6 in Dephosphorylation of Bcl11b, a Tumor Suppressor Transcription Factor

Activation and Nuclear Translocation of the Transcription Factor Nrf2 by the MAP Kinase Family

Voluntary alcohol consumption in male rhesus macaques suppresses cancellous bone remodeling

Investigation of the roles of viral proteinases in the vaccinia virus life cycle

The role of CYP2E1 and CYP4A in the development of non-alcoholic steatohepatitis

Comparing 26S Proteasome Efficiency Between Long-Living and Short-Living Rodents

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