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Filtering by: Creator Svesko, Andrew M. Remove constraint Creator: Svesko, Andrew M. Degree Field Biochemistry and Biophysics Remove constraint Degree Field: Biochemistry and Biophysics Degree Name Honors Bachelor of Science (H.B.S.) Remove constraint Degree Name: Honors Bachelor of Science (H.B.S.)

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  • Investigating the Role of the MutLα Endonuclease

    Creator:
    Mankaney, Gautam Naresh
    Abstract:
    Lynch individuals have a predisposition to developing colorectal and other cancers due to inherited defects in their mismatch repair (MMR) system. Although mutations in MMR have been directly implicated in Lynch Syndrome, the precise mechanism(s) of MMR functions have yet to be elucidated. One essential complex, MutL (a dimer of...
    Resource Type:
    Honors College Thesis
    Full Text:
    . Abstract Approved:________________________________________________________ Andrew Buermeyer Lynch

  • A Novel Approach to the Biochemical Analysis of Variants in the Essential DNA Mismatch Repair Protein MLH1

    Creator:
    Nguyen, Andrew
    Abstract:
    Genomic integrity is crucial for the viability and function of a cell. One key pathway that acts to maintain genomic integrity is DNA mismatch repair (MMR). MMR acts to correct base pair mismatches hat have escaped proofreading during DNA replication. The process of MMR is dependent on the protein heterodimer...
    Resource Type:
    Honors College Thesis
    Full Text:
    Andrew Nguyen Honors Thesis AN ABSTRACT OF THE

  • Pathogenic Mechanisms of Cancer Causing hMLH1 Mutations

    Creator:
    O'Donnell, Edmond Francis
    Abstract:
    DNA mismatch repair (MMR) is an evolutionary conserved process that functions to maintain genomic integrity through the correction of mismatches that have escaped proofreading. Mutations in the MMR gene Mlh1 are associated with approximately 50% of all cases of Lynch syndrome, a hereditary predisposition to colorectal cancer, through varying and...
    Resource Type:
    Honors College Thesis
    Full Text:
    . Abstract Approved: Andrew Buermeyer DNA mismatch repair (MMR) is an evolutionary conserved process that

  • Peptide Non-planarity Regained

    Creator:
    Biel, Justin T.
    Abstract:
    The planar peptide model has guided our understanding and interpretation of protein crystal structures since its origin in the 1950s. It is well understood that deviations from this model occur, but the majority of peptides are planar, as measured by the standard omega torsion angle. Here, we report the first...
    Resource Type:
    Honors College Thesis
    Full Text:
    : ________________________________________ P. Andrew Karplus

  • Nongenomic Actions of Steroid Hormones in the Ovine Endometrium

    Creator:
    Ireton, Kyle E.
    Abstract:
    The steroid hormone estrogen plays a crucial role in regulating certain mammalian tissues, especially female reproductive systems. Estrogen effects physiological changes in the cell by altering transcription activity for certain target genes, as a consequence of interactions between estradiol-17β (E2) and its nuclear receptor (nER). This mechanism of cellular control...
    Resource Type:
    Honors College Thesis
    Full Text:
    ______________________________________________________________________________ Dr. Andrew Karplus, Committee Representative, Biochemistry and Biophysics

  • Characterization and Functionalization of Fabric for use in an Immunoassay

    Creator:
    White, Natalie
    Abstract:
    Paper-based microfluidic assays, like the common pregnancy test, allow for rapid screening at the point- of-care at low cost and with no instrumentation. Fabric has many similar properties to paper, but is more flexible and durable, making it a promising option for use in a variety of diagnostic and screening...
    Resource Type:
    Honors College Thesis
    Full Text:
    _____________________________________________________________________ Andrew Karplus, Committee Member, representing the Department of Biochemistry and Biophysics

  • Activation and Nuclear Translocation of the Transcription Factor Nrf2 by the MAP Kinase Family

    Creator:
    Nguyen, Ngan H.
    Abstract:
    Eukaryotic cells have developed elaborate biochemical processes to counteract oxidative stress, electrophiles, or carcinogens due to environmental insults. One of these important cellular defense mechanisms is mediated by the transcription factor Nrf2 that have been shown to have decrease activity with age. While the process of which Nrf2 is involved...
    Resource Type:
    Honors College Thesis
    Full Text:
    ___________________________________________________________________________ Dr. Andrew Karplus, Chair, Department of Biochemistry and Biophysics

  • Involvement of PP6 in Dephosphorylation of Bcl11b, a Tumor Suppressor Transcription Factor

    Creator:
    Parker, Chelsea R.
    Abstract:
    The purpose of this honors thesis research project is to investigate the molecular causes of childhood and infant T-cell acute lymphoblastic leukemias. T-cells are the work horses of the immune system, and like any organ, must develop properly to be fully functional. Improper development of thymocytes into T-cells can lead...
    Resource Type:
    Honors College Thesis
    Full Text:
    : _________________________________________ Theresa M. Filtz The purpose of this honors thesis research project is to investigate the

  • Interaction of the human Voltage-Dependent Anion Channel 1 protein (VDAC-1) with Mycobacterium avium and its role in bacterial survival within phagocytic cells

    Creator:
    Pham, Tuan
    Abstract:
    M. avium is an opportunistic pathogen that primarily infects macrophages. In order to survive within the macrophage, M. avium secretes proteins into the host cell cytoplasm to inhibit specific functions such as phagosome acidification, altering pathways as well as initiating apoptosis. However, little is known about how those secreted proteins...
    Resource Type:
    Honors College Thesis
    Full Text:
    Bermudez Abstract M. avium is an opportunistic pathogen that primarily infects macrophages. In

  • UVB Radiation Affects the Quality of the Female Sexual Attractiveness Pheromone of the Red-Sided Garter Snake

    Creator:
    Vigeland, Anna E.
    Abstract:
    In this study, pheromone and skin lipid samples collected from red-sided garter snakes (Thamnophis sirtalis parietalis) were exposed directly to either full-spectrum light or full-spectrum plus UVB light. In addition, female and male snakes were exposed to daily doses of either full-spectrum or full-spectrum and UVB light, after which the...
    Resource Type:
    Honors College Thesis
    Full Text:
    , Joseph M.; Blaustein, Andrew R. and Belden, Lisa K. (2001). Complex causes of amphibian population