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Filtering by: Degree Field Biochemistry and Biophysics Remove constraint Degree Field: Biochemistry and Biophysics Language English [eng] Remove constraint Language: English [eng] Non-Academic Affiliation Oregon State University. Honors College Remove constraint Non-Academic Affiliation: Oregon State University. Honors College

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An Evaluation of Community Attitudes Towards Gender-Based Violence in Partnership with the Community of Maunatlala, Botswana

Creator:

Petrina, Grace E.

Abstract:

Gender-based violence (GBV) is a pervasive public health issue that continues to affect women globally. GBV is estimated to impact 37% of Botswanan women, exceeding the average global prevalence of 30%. This investigation takes place within the Botswana Global Health Initiative, a collaboration led by OSU researchers, the community of...

Resource Type:

Honors College Thesis
The analysis of kisspeptin neuronal exosomes and their effects on neuronal plasticity of downstream gonadotropin-releasing hormone expressing neurons

Creator:

Ewton, Jessica

Abstract:

Gonadotropin-releasing hormone (GnRH) neurons are able to trigger the release of luteinizing hormone and follicle-stimulating hormone which control the maturation of oocytes and ovulation which is vital for reproduction. They are the most downstream neurons that project to the median eminence into the pituitary portal where they release GnRH. Modulation...

Resource Type:

Honors College Thesis
Characterization and Functionalization of Fabric for use in an Immunoassay

Creator:

White, Natalie

Abstract:

Paper-based microfluidic assays, like the common pregnancy test, allow for rapid screening at the point- of-care at low cost and with no instrumentation. Fabric has many similar properties to paper, but is more flexible and durable, making it a promising option for use in a variety of diagnostic and screening...

Resource Type:

Honors College Thesis
Selection of an Orthogonal tRNA Synthetase for Trifluoromethyl-phenylalanine in Methanomethylophilus Alvus System

Creator:

Eyberg, Daniel R.

Abstract:

Genetic code expansion is a technology that allows for site-specific incorporation of noncanonical amino acids into recombinant proteins at amber stop codons using engineered translational machinery. The technology allows for expanded study into proteins, derived from the integration of novel chemical functions found in noncanonical amino acids, such as fluorescence,...

Resource Type:

Honors College Thesis
A taxonomy of biomolecular features

Creator:

North, Jacob L.

Abstract:

The scientific method applies hypothesis testing to material samples through experimentation, measurement, and data analysis, which produce representations—or features—that describe phenomena of interest. Biomolecular features come in numerous forms such as values, matrices, graphs, three-dimensional structures, trajectories, and molecular surfaces. Researchers have tested thousands of features related to protein molecules...

Resource Type:

Honors College Thesis
Characterization of the SARS-CoV-2 Nucleocapsid Protein and the Binding to Different Sections of the SARS-CoV-2 Genome

Creator:

Pinckney, Seth H.

Abstract:

The nucleocapsid protein (N protein) of the severe acute respiratory syndrome coronavirus 2 is known to play an essential part of the virus’ functions. The N protein can protect and package the large 29,903 nucleotide genomic RNA whilst also interacting with structural membrane protein M and the spike protein S....

Resource Type:

Honors College Thesis
Impaired epidermal homeostasis in Bcl11bR3S/R3S homozygous mutant mice

Creator:

Kelly, Avalon G.

Abstract:

BCL11B, also known as CTIP2, is a transcription factor which plays a critical role in the regulation and development of many tissues and organ systems, including the skin. A 2019 study by Goos et. al. uncovered a novel point mutation in BCL11B gene that converted the Arginine(R)-3 residue to a...

Resource Type:

Honors College Thesis
A Panel of Histone H3 Mutations to Investigate Centromere Maintenance and Gene Silencing

Creator:

Geisler, Mark S.

Abstract:

Histones, as part of nucleosomes, are responsible for DNA packaging in chromosomes. They also affect DNA expression by a multitude of post-translational modifications, especially prevalent on the amino terminus of histones. Co-activator protein complexes “write”, “read”, or “erase” histone modifications, and in balance determine which sections of DNA are free...

Resource Type:

Honors College Thesis
A Bayesian Treatise on the Replication Crisis in Science

Creator:

Gibson, True E.

Abstract:

Over the past decade, it has come to light that many published scientific findings cannot be reproduced. This has led to the replication crisis in science. Many researchers feel that they can no longer trust much of what they read in scientific journals, and the public is becoming ever more...

Resource Type:

Honors College Thesis
The Cathelicidin Anti-microbial peptide gene alters the mouse gut microbiome

Creator:

Rouches, Miles V.

Abstract:

The gut microbiome influences human disease including Type 2 diabetes, obesity and metabolic syndrome and interacts with the innate immune system. The human cathelicidin antimicrobial peptide (hCAMP), an important component of the innate immune system, and vitamin D and xanthohumol, a natural compound found in beer hops, regulate its expression....

Resource Type:

Honors College Thesis
Artistic Interpretation of the Significance of Human Breast Cancer Cell Vinculin Distribution in Different Extracellular Matrix Conditions

Creator:

Hsiao, Yu-Tin

Abstract:

There are clues that suggest human breast cancer cells use collagen fibers to migrate, and vinculin is a transmembrane protein associated with how cells attach to their environment. Therefore, immunostaining for the vinculin will shed some light in how human breast cancer cells are attaching to their environment. Immunostaining for...

Resource Type:

Honors College Thesis
Classification and Analysis of Nucleotide - Nucleotide Interactions in RNA

Creator:

Rouches, Mason

Abstract:

Base-pairing interaction are the fundamental blocks of an RNA structure. With increased ability to determine the structure of RNA molecules, an accurate and informative way of classifying these interactions would help to study RNA structure at many levels. Apart from the well-known complementary base pairs and wobble pairs, other interactions...

Resource Type:

Honors College Thesis
Lipids of the Stratum Corneum as Predictive Biomarkers for the Development of Atopic Dermatitis in a Pediatric Population

Creator:

Sato, William

Abstract:

Atopic Dermatitis (AD) is a widespread skin disorder, affecting some 20% of the world’s population. Though the precise molecular underpinnings are still being understood, changes in lipid composition within the epidermal stratum corneum (SC) layer have been shown to be closely linked with AD. Previous studies have identified several specific...

Resource Type:

Honors College Thesis
Ke Truyen Ma : Vietnamese Refugees Altering The Course of U.S. History, Kể Truyện Ma : Vietnamese Refugees Altering The Course of U.S. History

Creator:

Nguyen, Hai Yen T.

Abstract:

Since the 1960s, Vietnamese scholars have written autobiographical literature catered to the American public though they have not gotten as much recognition as soldier accounts and anti-war literature. These Vietnamese literatures shifted in scope and form with the succeeding waves of refugee resulted from the war in Việt Nam. As...

Resource Type:

Honors College Thesis
Investigation of KHV DNA Methylation during Productive and Latent Infection

Creator:

Lin, Lisa

Abstract:

Koi herpesvirus (KHV), is a highly pathogenic virus causing high mortality in common carp and koi, especially in fry. One of the unique features of herpesvirus infections is their ability to become latent following initial infection. During latent infection, only viral genome persists in the host and remains dormant in...

Resource Type:

Honors College Thesis
Assessing an Adult Zebrafish Model for In Vivo Delivery of Morpholino Oligomers

Creator:

Kim, Joseph Y.

Abstract:

Antisense morpholino oligomers are synthetic macromolecules can modify gene expression. While these compounds have great potential to treat a broad range of human diseases, they suffer from poor cellular delivery. Conjugating cell-penetrating peptides onto these morpholinos is one option of addressing delivery, however development remains slow due to the cost...

Resource Type:

Honors College Thesis
Adaptation to long-term osmotic stress in a domesticated Saccharomyces cerevisiae strain

Creator:

Holman, Douglas S.

Abstract:

Osmotic stress is a common challenge faced by organisms in environments with variable salinity or aridity. Understanding the evolutionary mechanisms underlying adaptation to osmotic stress may have wide applications, including management of populations experiencing climate change, or engineering industrial organisms involved in processes such as fermentation. While Saccharomyces cerevisiae is...

Resource Type:

Honors College Thesis
Characterizing the Interactome of Nitrotyrosine-Calmodulin using Genetic Code Expansion

Creator:

Kong, Garth L.

Abstract:

A specific tyrosine post-translational modification, called 3-nitro-tyrosine (nitroTyr), has been known to be present on an essential calcium signaling protein called calmodulin (CaM) during oxidative stress. While protein-bound 3-nitro-tyrosine has long been considered a biomarker of OS, it is also hypothesized to be a mechanism for protein signaling. However, purification...

Resource Type:

Honors College Thesis
Mutation of Polycomb Repressive Complex 2 (PRC2) kmt6 to Probe in vivo Function in Fusarium

Creator:

Josephson, Brian

Abstract:

Polycomb Repressive Complex 2 (PRC2) is a histone methyltransferase that initiates facultative heterochromatin formation by trimethylating histone H3 on lysine 27 (H3K27me3). Mutations within its three primary subunits, KMT6, EED, and SUZ12, result in inherited diseases and sporadic cancers. In the fungus Fusarium graminearum, deletion of the gene encoding the...

Resource Type:

Honors College Thesis
Oregon State Student Athlete Academic Performance Compared to that of the General Undergraduate Population

Creator:

Hannan, Joely

Abstract:

Academic performance of student athletes is an of interest topic in the current climate of rising university athletics expenses. This project academic population of Oregon State University student athletes with that of the general undergraduate population using grade point averages (GPA). Samples were compared using team, gender, college, and sport...

Resource Type:

Honors College Thesis
The role of sigma factors in production of cyanobacterial natural products: Escherichia coli as a heterologous expression host

Creator:

Wells, Kaitlyn N.

Abstract:

Cyanobacteria represent an underexploited source of bioactive natural products of interest to the pharmaceutical industry. Lack of development of these compounds as drug leads is due mainly to myriad practical problems with the producing strains including long doubling times, genetic intractability, and low compound yields. Previous attempts at heterologous expression...

Resource Type:

Honors College Thesis
Voluntary alcohol consumption in male rhesus macaques suppresses cancellous bone remodeling

Creator:

Kahler-Quesada, Arianna M.

Abstract:

Background: Chronic heavy alcohol consumption is a risk factor for bone fracture. Using a non-human primate model of voluntary alcohol self-administration, we have recently shown that alcohol consumption suppresses intracortical bone remodeling. The current study extends this investigation to asses the effect of alcohol consumption on cancellous bone mass, architecture,...

Resource Type:

Honors College Thesis
Pregnant in Puerto Rico : Maternal Perceptions of Zika- and Non-Zika Related Stress

Creator:

Nako, Eni

Abstract:

The purpose of this study was to examine pregnant Puerto Rican women’s perspectives on the Zika virus threat. Using data collected from open-ended, semi-structured interviews and observational field notes, we aimed to understand the degree to which Zika contributes to maternal stress. How concerned are pregnant women in Puerto Rico...

Resource Type:

Honors College Thesis
It's Not You, It's Me : An Inductive Exploration of Employee Accounts for Quitting

Creator:

Neaves, Emily

Abstract:

Key Words: Exit interview, voluntary turnover, dishonesty

Resource Type:

Honors College Thesis
Science performance of United States youth on international exams : A cross-cultural meta-synthesis

Creator:

Huss, Christiana H.

Abstract:

The purpose of this meta-synthesis was to investigate why students from the U.S. receive the scores they do on the international TIMSS and PISA science exams. This work sought to shed light on the perceived disparity between science performance of U.S. students and students from other countries. To do so,...

Resource Type:

Honors College Thesis
Comparative analysis of genes regulating HDL function and metabolism in macaques and humans

Creator:

Clarke, Jordyn M.

Abstract:

The role of the high density lipoprotein (HDL) molecule is currently an area of great interest within the scientific community. Previously, mouse and human studies have demonstrated an inverse association between HDL cholesterol (HDL-C) levels and cardiovascular disease. Recent clinical trials, which increased HDL-C, have failed to reduce the number...

Resource Type:

Honors College Thesis
An Accumulation of Senescent Cells May Contribute to Chronic Inflammation of the Mammalian Liver

Creator:

Sugiyama, Aaron

Abstract:

The aging process is a biological phenomenon in mammals that heavily contributes to the onset of chronic diseases. While there are many theories that attempt to explain the biological onset of aging, one emerging theory involves chronic inflammation. Chronic inflammation has been previously linked to several age-related diseases and is...

Resource Type:

Honors College Thesis
Effects of 6 months of voluntary alcohol self-administration on intracorticalbone remodeling in young adult male cynomolgus monkeys

Creator:

Kuah, Amida F.

Abstract:

Heavy chronic alcohol consumption has been linked to a myriad of detrimental skeletal effects. Many studies have been conducted to examine the effects of alcohol abuse upon cancellous bone. However, little is known about its effect upon cortical bone. The skeleton is comprised of approximately 80% cortical bone and thus...

Resource Type:

Honors College Thesis
Comparing 26S Proteasome Efficiency Between Long-Living and Short-Living Rodents

Creator:

Bradley, Lynda M.

Abstract:

Many people die yearly worldwide due to diseases associated with aging, and if the process of aging in humans was more understood, the health of these patients could be improved. While many biochemical actions are involved with the aging process, loss of proteostasis has been called one of the most...

Resource Type:

Honors College Thesis
Thermodynamic Design Principles for Double-Strand Displacement microRNA Biosensors

Creator:

Smith, Natasha M.

Abstract:

In recent years, microRNA’s (miRNA’s) have emerged as important in regulating gene expression. Fluctuations in their levels are associated with the up or down-regulation of tumor-suppressor genes and oncogenes. Thus, the ability to visualize changes in miRNA is an important step in understanding cancer emergence and development. The Burrows group...

Resource Type:

Honors College Thesis
Examining the Human Relevance of a New Mouse Model of ALS and Observations on the Incidence in Human Populations

Creator:

Winkenbach, Lindsay

Abstract:

Amyotrophic Lateral Sclerosis (ALS) is a relatively rare neurodegenerative disorder that is fatal 2-4 years after the onset of the disease. Population studies are being done in order to help reveal candidates for further studies of disease etiology, disease progression, as well as to further understand racial and ethnic variations....

Resource Type:

Honors College Thesis
Site-Specific Modification of Glucose Proteins Enabling Precise Surface Orientation For Glucose Sensors

Creator:

Wolfenden, Nurhayati

Abstract:

An ideal labeling reaction between protein and surface should generate a protein-patterned surface with control over the orientation of the desired protein. Controlling orientation would generate a homogeneous, un-fouled protein surface and allow for maximum efficiency in regards to the activity, reactivity, and stability of the protein. In this research...

Resource Type:

Honors College Thesis
Analysis of particulate organic matter distribution along surface waters of the California Current

Creator:

Welch, Kylie

Abstract:

Water samples along the Washington, Oregon and California coastline were collected using high resolution sampling and analyzed to determine particulate organic carbon and nitrogen concentrations. Over 28 days during August 2011, nearly 1500 samples were collected aboard the R/V Wecoma (W1108C) using a semi-automated filtration system. Additional subsurface samples were...

Resource Type:

Honors College Thesis
Investigation of autophagy-assisted cell death in response to the cancer cell toxin coibamide A

Creator:

Tan, Michelle

Abstract:

Autophagy, a homeostatic degradation pathway, has a role in promoting cell survival under stress conditions, but can also promote cell death under conditions of sustained stress. This project investigates the cytotoxic potential of coibamide A and other natural products in autophagy-deficient and wild-type mouse embryonic fibroblasts (MEFs). Wild-type MEFs were...

Resource Type:

Honors College Thesis
Generation of multiple geneauxotrophs for use as selectable markers in Fusarium graminearum

Creator:

Fargo, Corinne Marie

Abstract:

Auxotrophic strains of the fungus Fusarium graminearum were generated in order to increase the number of functional selectable markers and improve the utility of the model organism. Single metabolic genes, the sequences encoding for enzymes required for the production of specific essential metabolites, were deleted in F. graminearum, and then...

Resource Type:

Honors College Thesis
Isolation, Characterization, and Antibiotic Activity of Fungal Metabolites from an Algal Endophyte

Creator:

Stoumbos, Demetri

Abstract:

Pseudomonas aeruginosa is a gram-negative nosocomial pathogenic bacterium known for its resilience against antibiotics. The bacterium infects over 50,000 patients each year in the United States, with 13% of reported cases involving multi-drug-resistant strains of Pseudomonas. This research discovered several fungal natural products with promising activity against Pseudomonas aeruginosa. The...

Resource Type:

Honors College Thesis
Transportation Design To Facilitate Urban Growth In Pakistan: Structural Reform For Economic Mobilization

Creator:

Khan, Lubna

Abstract:

There is a rapid shift towards urbanization all over the world. In developing countries like Pakistan, the urbanization process is under-planned leading to the haphazard growth of existing cities without enough resources to fit the needs of the residents. Cities in Pakistan lack good transportation systems, which creates inaccessibility to...

Resource Type:

Honors College Thesis
Adding value to renewable biodiesel production from the oleaginous yeast Lipomyces starkeyi

Creator:

Brosy, Jack R.

Abstract:

Global warming and on-going depletion of fossil fuels have stimulated research to develop renewable sources of energy. Current renewable energy use comprises only 10% of the energy consumed in the US and is focused mostly on generating electricity. The majority of the energy consumed by the US transportation sector is...

Resource Type:

Honors College Thesis
Investigating compounds to target glioblastoma progression

Creator:

Cade, Emily Elizabeth

Abstract:

Glioblastoma multiforme is a devastating primary brain tumor with a median five year survival rate of less than 5%. It is a cancer that is resistant to current cancer treatments, such as surgery and chemotherapy, as well as one that is prone to recurrence after surgical removal. This highlights the...

Resource Type:

Honors College Thesis
A quantitative analysis of three-dimensional contact guidance by breast cancer cells

Creator:

Krnacik, Emma A.

Abstract:

Exploring and quantifying the parameters regarding contact guidance may provide valuable insight to the precise mechanisms controlling cell movement, especially in a three-dimensional environment. The objective of this project was to quantify the relationship between MDA-MB-231 cell morphogenesis and the geometry of the cell’s local microenvironment, which was modeled by...

Resource Type:

Honors College Thesis
Exposure to the Mycotoxin Zearalenone Impairs Embryonic Development in Zebrafish

Creator:

Sidebotham, Nicole A.

Abstract:

A study was conducted to evaluate the developmental toxicity of three commonly detected mycotoxins in food (deoxynivalenol, patulin, and zearalenone) using the zebrafish (Danio rerio) model. Mycotoxin exposures were carried out at five concentrations (0.0064, 0.064, 0.64, 6.4, and 64 μM). Morphological and photomotor screenings were conducted at 24 hours...

Resource Type:

Honors College Thesis
Characterization of Fer1L6 in the mouse C2C12 cell line

Creator:

Huegel, Jacob T.

Abstract:

Fer1L6 is an uncharacterized member of the ferlin family of proteins, a group of large, calcium sensitive proteins with emerging roles in vesicle trafficking and various disease states. The presence of Fer1L6 has been identified within the C2C12 cell line of mouse skeletal muscle. To determine the protein’s subcellular location...

Resource Type:

Honors College Thesis
Exploring the neuroprotective mechanism of poly-ICLC preconditioning against oxygenglucose deprivation in the in vitro blood-brain barrier model

Creator:

Turina, Claire B.

Abstract:

The preconditioning agent poly-ICLC has recently been shown to protect against cerebral injury in the mouse model, when administered systemically prior to ischemic insult. However, the mechanism by which poly-ICLC provides neuroprotection is currently unknown, but it has been shown to protect against ischemia-induced bloodbrain barrier (BBB) disruption. Inflammation contributes...

Resource Type:

Honors College Thesis
Identification of potential new biomarkers of oxygenated polycyclic aromatic hydrocarbon (OPAH) exposures in zebrafish.

Creator:

Swanson, Annika J.

Abstract:

Oxygenated polycyclic aromatic hydrocarbons (OPAHs) are a class of environmentally prevalent compounds with little known information on their effect in vivo. In a recent study conducted using zebrafish as a model, 38 OPAHs were screened for toxicity. This investigation focuses on two of these OPAHs, 7,12-B[a]AQ and BEZO. Both 7,12-B[a]AQ...

Resource Type:

Honors College Thesis
Calpain 2 Cleavage of Akt in Glioblastoma Multiforme

Creator:

Zhang, Justin

Abstract:

Glioblastoma is a malignant brain tumor that has extremely poor prognoses with a 5 year survival rate of less than 5%. The low survival rates of glioblastoma patients is attributed to glioblastoma cells being extremely resistant to radiotherapy and chemotherapy as well as being very invasive. We previously identified calpain...

Resource Type:

Honors College Thesis
Quantification of Lipoic Acid InducedChanges in Nrf2-Mediated Stress Response

Creator:

Hobbs, Helen T.

Abstract:

As organisms age they lose the ability to respond to both exogenous and endogenous stresses, therefore placing them at a greater risk for the development of many diseases. The transcription factor Nrf2 is responsible for the induction of many oxidative stress response genes and therefore 3proteins. Additionally, Nrf2-mediated stress response...

Resource Type:

Honors College Thesis
The Creation of a Bilingual Children’s Book to Promote Mental Health Services among U.S. Latin@s

Creator:

Tolmach, Oresta S.

Abstract:

Although U.S. Latin@s are more affected by major depressive disorder than non-Latin@ whites, they are less likely to utilize mental health services. The purpose of this project is to create a children’s book that promotes the utilization of mental health services among U.S. Latin@s with major depressive disorder. This book...

Resource Type:

Honors College Thesis
Interaction of the human Voltage-Dependent Anion Channel 1 protein (VDAC-1) with Mycobacterium avium and its role in bacterial survival within phagocytic cells

Creator:

Pham, Tuan

Abstract:

M. avium is an opportunistic pathogen that primarily infects macrophages. In order to survive within the macrophage, M. avium secretes proteins into the host cell cytoplasm to inhibit specific functions such as phagosome acidification, altering pathways as well as initiating apoptosis. However, little is known about how those secreted proteins...

Resource Type:

Honors College Thesis
Ernesto "Che" Guevara : An Analysis of What the Argentine Revolutionary Truly Personified and the Accuracy of Representation in American Culture

Creator:

Judd, Grace I.

Abstract:

It is no doubt that the face of Ernesto "Che" Guevara is recognized globally as it appears on currency, merchandise, at protest marches, and in art. However, there is little agreement on what this handsome face represents or what the Argentine revolutionary fought for. Some view Guevara as a humanitarian...

Resource Type:

Honors College Thesis
Permeability of Various Thyroid Hormone Derivatives and Discovery of a Novel Metabolite

Creator:

Kirkemo, Lisa

Abstract:

In this investigation, six different endogenous thyroid hormone derivatives—T₄, T₃, TA₄, TA₃, T₁-Amine, and N-Acetylated T₁-Amine—were tested to gain insight into their permeability coefficients and efflux ratios across a monolayer of Madin-Darby Canine Kidney (MDCK II) cells. The results indicate that T₃ and T₄ were unable to traverse the membrane...

Resource Type:

Honors College Thesis

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Ahern, Kevin6
Freitag, Michael5
Hagen, Tory M.4
Buermeyer, Andrew3
Cheyney, Melissa3
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Current results range from 1999 to 2023

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Ahern, Kevin3
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Bai, Daniel Helin1
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Carrington, James C.1
Esposito, Madison1
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Current results range from 1999 to 2023

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Biochemistry and Biophysics[remove]85
International Studies4
Microbiology2
Spanish2
Anthropology1
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Bachelor's85

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Honors Bachelor of Science (H.B.S.)85
Honors Bachelor of Arts (H.B.A.)4

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application/pdf1

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English [eng][remove]85

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Oregon State University. Honors College[remove]85
Oregon State University. Undergraduate Research, Scholarship, and the Arts (URSA)3
Oregon State University. Bioresource Research1
Oregon State University. Celebration of Undergraduate Excellence1

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No85

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Honors College Thesis85

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In Copyright - Educational Use Permitted2

Subject

Active oxygen in the body1
Bayesian statistical decision theory1
Colon (Anatomy) -- Cancer -- Genetic aspects1
Cytochrome P-4501
Cytochrome P-450 CYP2E11
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