Index Catalog // ScholarsArchive@OSU

Cyclic nucleotides, cyclic nucleotide phosphodiesterase, protein kinase, and phosphoprotein phosphatase in the central nervous system of Manduca sexta

Creator:: Albin, Edward Elmo
Abstract:: Adenosine 3', 5' -cyclic monophosphate (cyclic AMP, cAMP) and guanosine 3', 5' -cyclic monophosphate (cyclic GMP, cGMP) were quantitated in the central nervous system (CNS) of the insect Manduca sexta by competitive protein binding techniques. The M. sexta CNS was found to contain a strikingly high level of cGMP, about...
Resource Type:: Dissertation
Full Text:: cyclic nucleotide- stimulable protein kinases (ATP: protein phosphotransferase, EC 2. 7. 1. 37), a

Biophysical basis of macromolecular assembly in the dynein cargo attachment complex

Creator:: Hall, Justin Daniel
Abstract:: Cytoplasmic dynein is an ATP-dependent, microtubule-based molecular motor involved in the positioning and trafficking of cellular cargo. The cargo binding sub-domain of dynein contains the natively disordered intermediate chain (IC) and the homodimeric light chains (Tctex1, LC8 and LC7). The structure and stoichiometry of this complex, how the light chains...
Resource Type:: Dissertation

Glutamate dehydrogenase : I.Flourescence polarization studies of the self-association. II.Flourescence and circular dichroism studies of the heterotropic interactions

Creator:: Malencik, Dean Anthony
Abstract:: Fluorescence polarization measurements on beef liver glutamate dehydrogenase conjugated with pyrene butyric acid demonstrate that the association of the enzyme is adequately described by a reversible indefinite association with a single equilibrium constant. The data obtained with protein concentrations up to 0.7 mg/ml in 0.05 M potassium phosphate, pH 7....
Resource Type:: Dissertation
Full Text:: liver L-glutamate dehydrogenase (BL-GDH) (EC 1.4. 1. 3) was first isolated by Olson and Anfinsen (1952

Assembly and Regulation of WW-PPXY Complexes in Hippo Signaling

Creator:: Baker, Kasie J.
Abstract:: The Hippo signaling pathway is an evolutionarily conserved regulator of cell growth, proliferation, and apoptosis. A key function of the pathway is to regulate the subcellular distribution and activity of Yorkie in Drosophila or Yes-associated protein (YAP) and transcription co-activator with PDZ-binding motif (TAZ) in mammals. The dysregulation of the...
Resource Type:: Dissertation

Conformational Consequences: Calcium Regulates the Association Between Dysferlin C2A & PI(4,5)P2

Creator:: Otto, Shauna C.
Abstract:: Dysferlin is a ∼230 kDa terminally anchored membrane protein that is ubiquitously expressed, but is particularly enriched in skeletal and cardiac muscle tissue. Mutations covering the length of the protein have been linked to muscle wasting diseases including limb-girdle muscular dystrophy and Myoshi myopathy. Dysferlin has been shown to play...
Resource Type:: Dissertation

Age-related decrease in resilience against acute redox cycling agents: Critical role of declining GSH-dependent detoxification capacity

Creator:: Thomas, Nicholas O.
Abstract:: Over the past century, life expectancy in the United States has dramatically increased leading to an increasingly aging population with people reaching, and spending more years in ‘old age’. While this unprecedented shift in population demographics represents great strides for humanity, it is not without cost. One consequence of longer...
Resource Type:: Dissertation

Polychlorinated biphenyls and related metabolites : mode of action on phospholipid and glyceride biosynthesis

Creator:: Dzogbefia, Victoria Pearl
Abstract:: Polychlorinated biphenyls (PCBs) have been reported to cause alterations in the metabolism of phospholipids and glycerides in animals and humans. This project was undertaken in an attempt to determine the mode of action of PCBs and their primary metabolites on phospholipid and glyceride biosynthesis. The activity of sn-glycerol-3 phosphate acyltransferase...
Resource Type:: Dissertation

Novel icosanoids from the red marine alga Farlowia mollis

Creator:: Solem, Michele Lee
Abstract:: Farlowia mollis is a marine red alga that grows in the intertidal region along the coast of Oregon. We began studying the chemistry of this alga after a survey of Oregon seaweeds revealed possibly interesting chemistry and antimicrobial activity in its crude organic extract. Over the past three years the...
Resource Type:: Masters Thesis

Age-related loss of Nrf2, a novel mechanism for the potential attenuation of xenobiotic detoxification capacity

Creator:: Smith, Eric Jonathan
Abstract:: Nuclear Factor, Erythroid Derived 2, Like 2 (NFE2L2 or Nrf2) is the primary transcription factor in cellular defense against oxidative and xenobiotic stresses in higher eukaryotes. This basic leucine zipper transcription factor regulates over 200 antioxidant, detoxification, and lipid metabolizing genes by binding to the Antioxidant Response Element (ARE; a...
Resource Type:: Dissertation

In vivo Reactions of Tetrazines Incorporated through Genetic Code Expansion

Creator:: Blizzard, Robert J.
Abstract:: The inverse electron demand Diels Alder reaction between tetrazines and strained alkenes is an exceptionally useful tool in functionalizing to biomolecules since it is orthogonal to the chemistry of most living systems and have exceptionally high rate constants. In particular reactions between strained trans-cyclooctenes (sTCO) and tetrazines can achieve second...
Resource Type:: Dissertation

ScholarsArchive@OSU

Cyclic nucleotides, cyclic nucleotide phosphodiesterase, protein kinase, and phosphoprotein phosphatase in the central nervous system of Manduca sexta

Biophysical basis of macromolecular assembly in the dynein cargo attachment complex

Glutamate dehydrogenase : I.Flourescence polarization studies of the self-association. II.Flourescence and circular dichroism studies of the heterotropic interactions

Assembly and Regulation of WW-PPXY Complexes in Hippo Signaling

Conformational Consequences: Calcium Regulates the Association Between Dysferlin C2A & PI(4,5)P2

Age-related decrease in resilience against acute redox cycling agents: Critical role of declining GSH-dependent detoxification capacity

Polychlorinated biphenyls and related metabolites : mode of action on phospholipid and glyceride biosynthesis

Novel icosanoids from the red marine alga Farlowia mollis

Age-related loss of Nrf2, a novel mechanism for the potential attenuation of xenobiotic detoxification capacity

In vivo Reactions of Tetrazines Incorporated through Genetic Code Expansion

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