Index Catalog // ScholarsArchive@OSU

Conformational Consequences: Calcium Regulates the Association Between Dysferlin C2A & PI(4,5)P2

Creator:: Otto, Shauna C.
Abstract:: Dysferlin is a ∼230 kDa terminally anchored membrane protein that is ubiquitously expressed, but is particularly enriched in skeletal and cardiac muscle tissue. Mutations covering the length of the protein have been linked to muscle wasting diseases including limb-girdle muscular dystrophy and Myoshi myopathy. Dysferlin has been shown to play...
Resource Type:: Dissertation
Full Text:: m em b ra n e re p a ir , T -t u b u le b io g en es is a n d m a in te n a n ce R ef er en

Comparative analysis of genes regulating HDL function and metabolism in macaques and humans

Creator:: Clarke, Jordyn M.
Abstract:: The role of the high density lipoprotein (HDL) molecule is currently an area of great interest within the scientific community. Previously, mouse and human studies have demonstrated an inverse association between HDL cholesterol (HDL-C) levels and cardiovascular disease. Recent clinical trials, which increased HDL-C, have failed to reduce the number...
Resource Type:: Honors College Thesis
Full Text:: 20 40 60 80 100 120 AB CA 1 AB CG 1 AP OA 1 AP OA 2 AP OC 2 AP OC 3 AP OE CE

Assembly and Regulation of WW-PPXY Complexes in Hippo Signaling

Creator:: Baker, Kasie J.
Abstract:: The Hippo signaling pathway is an evolutionarily conserved regulator of cell growth, proliferation, and apoptosis. A key function of the pathway is to regulate the subcellular distribution and activity of Yorkie in Drosophila or Yes-associated protein (YAP) and transcription co-activator with PDZ-binding motif (TAZ) in mammals. The dysregulation of the...
Resource Type:: Dissertation

Revealing sequences and modifications of intact proteins using electron fragmentation

Creator:: Franklin, Rachel
Abstract:: People turn to mass spectrometry to answer some of life’s most important questions. From carbon dating of archeological finds to newborn blood screening tests, mass spectrometry allows us to measure molecules which helps advance our knowledge of life and the world we live in. One area of mass spectrometry that...
Resource Type:: Dissertation
Full Text:: 5.3 Intensity of NIST mAb light chain charge states with increasing CE ……..…....82 5.4 Sequence

Adding value to renewable biodiesel production from the oleaginous yeast Lipomyces starkeyi

Creator:: Brosy, Jack R.
Abstract:: Global warming and on-going depletion of fossil fuels have stimulated research to develop renewable sources of energy. Current renewable energy use comprises only 10% of the energy consumed in the US and is focused mostly on generating electricity. The majority of the energy consumed by the US transportation sector is...
Resource Type:: Honors College Thesis
Full Text:: C20:0 C22:0 C24:0 P er ce n t o f Fa tt y A ci d s Fatty Acid Composition YEPD-grown

Dietary organosulfur and organoselenium compounds as HDAC inhibitors

Creator:: Nian, Hui
Abstract:: Histone deacetylase (HDAC) inhibitors have the potential to de-repress epigenetically silenced genes in cancer cells, leading to cell cycle arrest and apoptosis. Dietary HDAC inhibitors derived from natural phytochemicals are promising anticancer agents. In this thesis, metabolites from natural organosulfur and organoselenium compounds, i.e. allyl mercaptan (AM), β-methylselenopyruvate (MSP) and...
Resource Type:: Dissertation

Defining the Role of Tyrosine Nitration in Biology with Genetic Code Expansion

Creator:: Porter, Joseph J.
Abstract:: The buildup of reactive oxygen species (ROS) and reactive nitrogen and oxygen species (RNS) is known as oxidative stress. Oxidative stress results in a wide variety of modification to biological macromolecules including nucleic acids, lipids, and proteins. For at least 30 years it has been known that high levels of...
Resource Type:: Dissertation

In vivo Reactions of Tetrazines Incorporated through Genetic Code Expansion

Creator:: Blizzard, Robert J.
Abstract:: The inverse electron demand Diels Alder reaction between tetrazines and strained alkenes is an exceptionally useful tool in functionalizing to biomolecules since it is orthogonal to the chemistry of most living systems and have exceptionally high rate constants. In particular reactions between strained trans-cyclooctenes (sTCO) and tetrazines can achieve second...
Resource Type:: Dissertation

Functional and Structural Analyses of Three Distinct proteins by Biochemical and Biophysical Techniques

Creator:: Codding, Sara Jone
Abstract:: The focus of this dissertation was to understand protein function and structure ona molecular level. To do this successfully, a variety of biochemical and biophysicaltechniques were employed. A wide variety of techniques were applied to study theproteins of interest in this dissertation to probe protein-protein interactions, proteinfunction, protein structure, and...
Resource Type:: Dissertation

Characterization of the mechanism and function of C₂H₂ zinc finger protein CTIP2 in the developmental processes

Creator:: Golonzhka, Olga
Abstract:: CTIP2 is a C2H2 zinc finger transcription factor that plays important yet poorly understood roles in mouse development. CTIP2 is known to be highly expressed in the central nervous system, skin and T lymphocytes during embryogenesis. CTIP2-null mice die perinatally of unknown causes and exhibit defects in multiple organ systems...
Resource Type:: Dissertation

ScholarsArchive@OSU

Conformational Consequences: Calcium Regulates the Association Between Dysferlin C2A & PI(4,5)P2

Comparative analysis of genes regulating HDL function and metabolism in macaques and humans

Assembly and Regulation of WW-PPXY Complexes in Hippo Signaling

Revealing sequences and modifications of intact proteins using electron fragmentation

Adding value to renewable biodiesel production from the oleaginous yeast Lipomyces starkeyi

Dietary organosulfur and organoselenium compounds as HDAC inhibitors

Defining the Role of Tyrosine Nitration in Biology with Genetic Code Expansion

In vivo Reactions of Tetrazines Incorporated through Genetic Code Expansion

Functional and Structural Analyses of Three Distinct proteins by Biochemical and Biophysical Techniques

Characterization of the mechanism and function of C₂H₂ zinc finger protein CTIP2 in the developmental processes

Limit your search

Academic Affiliation

Advisor

Commencement Year

Committee Member

Creator

Contributor

Date

Decade

Degree Field

Degree Level

Degree Name

Language

License

Non-Academic Affiliation

Peer Reviewed

Resource Type

Rights Statement

Subject

Search Constraints

Search Results

Limit your search