Index Catalog // ScholarsArchive@OSU

Conformational Consequences: Calcium Regulates the Association Between Dysferlin C2A & PI(4,5)P2

Creator:: Otto, Shauna C.
Abstract:: Dysferlin is a ∼230 kDa terminally anchored membrane protein that is ubiquitously expressed, but is particularly enriched in skeletal and cardiac muscle tissue. Mutations covering the length of the protein have been linked to muscle wasting diseases including limb-girdle muscular dystrophy and Myoshi myopathy. Dysferlin has been shown to play...
Resource Type:: Dissertation
Full Text:: AN ABSTRACT OF THE DISSERTATION OF Shauna C. Otto for

Towards Resolving Functional and Evolutionary Mysteries of the Large and Heterozygous Genome of Hop (Humulus lupulus) and the Cannabaceae Family Using Genomic Data Science

Creator:: Padgitt-Cobb, Lillian K.
Abstract:: Hop (Humulus lupulus L. var. lupulus) is a diploid, dioecious plant with an extensive history of cultivation and use in brewing, as a textile, and for its therapeutic properties. Hop is prized for its ability to produce a variety of aromatic and flavor compounds, as well as compounds with anti-microbial...
Resource Type:: Dissertation
Full Text:: : David A. Hendrix Hop (Humulus lupulus L. var. lupulus) is a diploid, dioecious plant with an exten

Partial purification and characterization of an Ls-NADP:isocitrate oxidoreductase from embryonic chick liver

Creator:: Engle, Wilbur Allen
Abstract:: An Ls-isocitrate:NADP oxidoreductase has been isolated and purified from embryonic chicken liver. The enzyme was purified 200 fold by means of ammonium sulfate fractionation, gel filtration chromatography on Sephadex G-200, ion-exchange chromatography on Bio-Gel CM-100 and adsorption chromatography on hydroxylapatite gel. The purified enzyme was nearly homogeneous as determined from...
Resource Type:: Dissertation

Biosynthesis, production and structural studies of secondary metabolites in cultured marine cyanobacteria

Creator:: Vulpanovici, Florina Alexandra
Abstract:: This thesis details investigations of marine cyanobacterial secondary metabolism, with emphasis on a strain of Phormidium sp. collected in Indonesia. These studies assessed the effects of nineteen putative elicitor compounds on the growth and metabolite production of five species of marine cyanobacteria, biosynthetic investigation of an intriguing secondary metabolite, phormidolide,...
Resource Type:: Dissertation
Full Text:: = 5.1 tM). Q Hectochlorin (14) Interestingly, hectochiorin was also isolated from a red L

Single-molecule in vitro Characterization of Otoferlin

Creator:: Hams, Nicole J.
Abstract:: Congenital hearing loss is a common disorder and over 60 mutations in the sensory hair cell protein, otoferlin, have been linked to pre-lingual deafness. Although otoferlin is essential for hearing, the large size and low solubility of the protein have limited approaches to study its function on a molecular-level. To...
Resource Type:: Dissertation
Full Text:: experiment design. Nicole J. Hams and Dr. Colin Johnson wrote the manuscript. Chapter 3 Shauna Otto

Modulation of deoxyribonucleoside triphosphate levels, DNA synthesis rates and fidelity in mammalian cells

Creator:: Martomo, Stella A.
Abstract:: Deoxyribonucleoside triphosphate (dNTP) concentrations measured in cells are not symmetric. dGTP almost always represents only 5-10% of the total dNTP pools in cells. In an in vitro replication system involving semiconservative replication from an SV 40 origin, the mutation frequency of an M13 phagemid replicated by human cell extracts in...
Resource Type:: Dissertation

Site-directed mutagenesis of the m2 muscarinic acetylcholine receptor

Creator:: Vogel, Walter Kevin
Resource Type:: Dissertation
Full Text:: ; Gary L. Peterson, David J. Broderick, and Michael H. Nesson for patiently instructing me in many of

DNA binding and beyond : an investigation of proteins involved in PAH-induced carcinogesesis

Creator:: Hooven, Louisa Ada
Abstract:: Exposure to polycyclic aromatic hydrocarbons such as benzo[a]pyrene (B[a]P) has been determined to be a risk factor for various forms of human cancer. PAH DNA adducts have been shown to cause mutations, but carcinogenesis is also accompanied by alterations in gene expression. Inhibiting individual cytochrome P450s could clarify the interaction...
Resource Type:: Dissertation

Characterizing the Functional Properties of Otoferlin, Essential for Neurotransmission in Inner Hair Cells of the Cochlea

Creator:: Narayanappa, Murugesh
Abstract:: Hearing loss is one of the most common defect, affecting 360 million people worldwide due to several factors including congenital, present at or soon after birth or acquired with age. Congenital hearing loss affects 32 million children in the world. The economic impact of hearing loss is estimated to cost...
Resource Type:: Dissertation
Full Text:: , Robert Remak and Otto Karl Deiters found undivided extensions from a nerve cell that they called as

Factors affecting the activation of rabbit muscle phosphofructokinase by actin

Creator:: Kuo, Huey-ju
Abstract:: The consistent application of phosphatase inhibitors and a novel final purification step using a connected series of DE-51, DE-52, and DE-53 anion exchange chromatography columns facilitate the preparation of electrophoretically homogeneous sub-pupulations of rabbit muscle phosphofructokinase which differ in their catalytic properties and endogenous covalent phosphate contents. A band of...
Resource Type:: Dissertation
Full Text:: . Phosphofructokinase is also strongly activated by low concentrations of NH4 1- or K+ (Otto, et al., 1976). All of

ScholarsArchive@OSU

Conformational Consequences: Calcium Regulates the Association Between Dysferlin C2A & PI(4,5)P2

Towards Resolving Functional and Evolutionary Mysteries of the Large and Heterozygous Genome of Hop (Humulus lupulus) and the Cannabaceae Family Using Genomic Data Science

Partial purification and characterization of an Ls-NADP:isocitrate oxidoreductase from embryonic chick liver

Biosynthesis, production and structural studies of secondary metabolites in cultured marine cyanobacteria

Single-molecule in vitro Characterization of Otoferlin

Modulation of deoxyribonucleoside triphosphate levels, DNA synthesis rates and fidelity in mammalian cells

Site-directed mutagenesis of the m2 muscarinic acetylcholine receptor

DNA binding and beyond : an investigation of proteins involved in PAH-induced carcinogesesis

Characterizing the Functional Properties of Otoferlin, Essential for Neurotransmission in Inner Hair Cells of the Cochlea

Factors affecting the activation of rabbit muscle phosphofructokinase by actin

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