Index Catalog // ScholarsArchive@OSU

The Role of Arabidopsis RNA-Dependent RNA Polymerase Genes 3, 4 and 5 in Antiviral Defense

Creator:: Lowery, Nicholas C.
Abstract:: RNA silencing plays a critical role in plant defense against viral infection. Plants use virusderived small interfering RNA to target and silence invading viruses. The antiviral silencing pathway can be broken down into three conceptual stages: initiation, amplification, and systemic movement. The molecular mechanisms of silencing initiation are not well...
Resource Type:: Honors College Thesis
Full Text:: -Ruiz H., A. Takeda, E. J. Chapman, C. M. Sullivan, N. Fahlgren, K. J. Brempelis, and J. C. Carrington

Modulation of deoxyribonucleoside triphosphate levels, DNA synthesis rates and fidelity in mammalian cells

Creator:: Martomo, Stella A.
Abstract:: Deoxyribonucleoside triphosphate (dNTP) concentrations measured in cells are not symmetric. dGTP almost always represents only 5-10% of the total dNTP pools in cells. In an in vitro replication system involving semiconservative replication from an SV 40 origin, the mutation frequency of an M13 phagemid replicated by human cell extracts in...
Resource Type:: Dissertation
Full Text:: . Abstract approved: Christopher K. Mathews Deoxyribonucleoside triphosphate (dNTP) concentrations measured

Towards Resolving Functional and Evolutionary Mysteries of the Large and Heterozygous Genome of Hop (Humulus lupulus) and the Cannabaceae Family Using Genomic Data Science

Creator:: Padgitt-Cobb, Lillian K.
Abstract:: Hop (Humulus lupulus L. var. lupulus) is a diploid, dioecious plant with an extensive history of cultivation and use in brewing, as a textile, and for its therapeutic properties. Hop is prized for its ability to produce a variety of aromatic and flavor compounds, as well as compounds with anti-microbial...
Resource Type:: Dissertation
Full Text:: AN ABSTRACT OF THE DISSERTATION OF Lillian K

Model systems for structural investigations into peroxiredoxin catalysis, conformation change, and inactivation

Creator:: Perkins, Arden
Abstract:: Peroxiredoxin (Prx) enzymes catalyze the reduction of hydrogen peroxide, peroxynitrous acid, and organic peroxides, and are extremely efficient peroxidases, with k[subscript cat]/K[subscript M] on the order of 10⁷ - 10⁸ M⁻¹ s⁻¹. Besides their role in oxidative stress defense, evidence has accumulated that some eukaryotes, including humans, use Prxs as...
Resource Type:: Dissertation

Age-related decrease in resilience against acute redox cycling agents: Critical role of declining GSH-dependent detoxification capacity

Creator:: Thomas, Nicholas O.
Abstract:: Over the past century, life expectancy in the United States has dramatically increased leading to an increasingly aging population with people reaching, and spending more years in ‘old age’. While this unprecedented shift in population demographics represents great strides for humanity, it is not without cost. One consequence of longer...
Resource Type:: Dissertation
Full Text:: concentrations of menadione, a vitamin K derivative and redox cycling agent, an LC50 for each age group

Interaction of the human Voltage-Dependent Anion Channel 1 protein (VDAC-1) with Mycobacterium avium and its role in bacterial survival within phagocytic cells

Creator:: Pham, Tuan
Abstract:: M. avium is an opportunistic pathogen that primarily infects macrophages. In order to survive within the macrophage, M. avium secretes proteins into the host cell cytoplasm to inhibit specific functions such as phagosome acidification, altering pathways as well as initiating apoptosis. However, little is known about how those secreted proteins...
Resource Type:: Honors College Thesis
Full Text:: membrane, VDAC-1 monomer is an important channel in which metabolites such as K+, Na+, Ca2+, ATP and NADH

Hydrogen-stimulated CO₂ fixation and coordinate derepression of hydrogenase and ribulosebisphosphate carboxylase in a H₂-uptake positive strain of Rhizobium japonicum

Creator:: Simpson, Frank Berry
Abstract:: H₂-uptake positive strains (122 DES and SR) and H₂-uptake negative strains SR2 and SR3 of Rhizobium japonicum were examined for ribulosebisphosphate (RuBP) carboxylase and H₂-uptake activities during growth conditions which induced formation of the hydrogenase system. The rate of ¹⁴CO₂ uptake by hydrogenase-induced cells was about six times greater in...
Resource Type:: Masters Thesis
Full Text:: shown to be a major factor that prevented H2 loss from nodules (Ruiz- Argileso et al., 1978; Evans et

Ti plasmid coded protein in Agrobacterium tumefaciens

Creator:: Engelgau, Michael Maurice
Abstract:: Agrobacterium tumefaciens is a plant pathogenic bacteria which incites crown gall tumors. Although virulence has been associated with a 97-156 Mdalton "tumor-inducing" (Ti) plasmid, few potential plasmid gene products have been identified. The objective of this study was to identify plasmid-coded gene products through a comparison of protein fingerprints of...
Resource Type:: Masters Thesis
Full Text:: (NH4)2504 15 2 KH 2 PO 4 .2 K 2 H P 0 4 .8 MgC12.6H20 33 NaC1 44 *FeC 13 3 CaNO 3 26 Na 2

A role for ceramide accumulation in age-related cardiac mitochondrial dysfunction

Creator:: Monette, Jeffrey S.
Abstract:: Ceramides are a group of lipids in the sphingolipid family that are potent cell signaling molecules. Elevations in ceramide levels above the norm generally lead to apoptosis. Evidence from in vitro studies suggests that accumulation of ceramides within mitochondria leads to dysfunction of the mitochondria. This includes inhibition of the...
Resource Type:: Dissertation

Alkylation kinetics of the human retinoid X receptor α using cysteine as a local probe

Creator:: Vanegas, Juan Manuel
Abstract:: The unfolding of human retinoid X receptor α in the presence of the denaturant guanidine HCl was studied using stopped-flow absorbance spectroscopy. The protein's four native cysteine residues were mutated to obtain four single-cysteine mutants, each with the other three cysteine residues mutated to alanine. The thiols of these hRXRα...
Resource Type:: Masters Thesis
Full Text:: , k'obs = 7.17 ± 0.12 s -1, k''obs = 0.173 ± 0.001 s -1. (B) Slow region fitted to eq. 1: B = 0.11900

ScholarsArchive@OSU

The Role of Arabidopsis RNA-Dependent RNA Polymerase Genes 3, 4 and 5 in Antiviral Defense

Modulation of deoxyribonucleoside triphosphate levels, DNA synthesis rates and fidelity in mammalian cells

Towards Resolving Functional and Evolutionary Mysteries of the Large and Heterozygous Genome of Hop (Humulus lupulus) and the Cannabaceae Family Using Genomic Data Science

Model systems for structural investigations into peroxiredoxin catalysis, conformation change, and inactivation

Age-related decrease in resilience against acute redox cycling agents: Critical role of declining GSH-dependent detoxification capacity

Interaction of the human Voltage-Dependent Anion Channel 1 protein (VDAC-1) with Mycobacterium avium and its role in bacterial survival within phagocytic cells

Hydrogen-stimulated CO₂ fixation and coordinate derepression of hydrogenase and ribulosebisphosphate carboxylase in a H₂-uptake positive strain of Rhizobium japonicum

Ti plasmid coded protein in Agrobacterium tumefaciens

A role for ceramide accumulation in age-related cardiac mitochondrial dysfunction

Alkylation kinetics of the human retinoid X receptor α using cysteine as a local probe

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