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Filtering by: Creator Nguyen, Tammy Remove constraint Creator: Nguyen, Tammy Degree Field Biochemistry and Biophysics Remove constraint Degree Field: Biochemistry and Biophysics

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  • Biophysical basis of macromolecular assembly in the dynein cargo attachment complex

    Creator:
    Hall, Justin Daniel
    Abstract:
    Cytoplasmic dynein is an ATP-dependent, microtubule-based molecular motor involved in the positioning and trafficking of cellular cargo. The cargo binding sub-domain of dynein contains the natively disordered intermediate chain (IC) and the homodimeric light chains (Tctex1, LC8 and LC7). The structure and stoichiometry of this complex, how the light chains...
    Resource Type:
    Dissertation
    Full Text:
    ; and Tammy Ayyoub, for so much (mostly solicited) good advice. Lastly, I would like to acknowledge