Index Catalog // ScholarsArchive@OSU

Characterizing the accumulation of cellular senescence in the PS19 mouse model

Creator:: Valerio, Juno, Riordan, Ruben, Dimas-Munoz, Jovita, Ross, Grace, Zhen, Yu, Wang, Rong, and Perez, Viviana
Abstract:: Research poster for Summer Undergraduate Research Symposium 2019. Research was conducted with CURE funding in the Perez lab studying cellular senescence in the PS19 mouse model.
Resource Type:: Poster
Full Text:: mice. • Western blotting was used to test for total Tau and P Tau levels. • Hind leg paralysis was

Context matters : assembly and disorder in the regulation of multivalent complexes

Creator:: Jara, Kayla A.
Abstract:: Intrinsically disordered proteins (IDPs), protein regions (IDRs), and protein complexes continue to emerge at the forefront of protein science. Proteins and protein regions lacking specific structure are found in all organisms, and often have vital roles in numerous biological processes. Breaking the well-known structure-function paradigm, the understanding of disorder-based functionality...
Resource Type:: Dissertation

Assembly and Regulation of WW-PPXY Complexes in Hippo Signaling

Creator:: Baker, Kasie J.
Abstract:: The Hippo signaling pathway is an evolutionarily conserved regulator of cell growth, proliferation, and apoptosis. A key function of the pathway is to regulate the subcellular distribution and activity of Yorkie in Drosophila or Yes-associated protein (YAP) and transcription co-activator with PDZ-binding motif (TAZ) in mammals. The dysregulation of the...
Resource Type:: Dissertation
Full Text:: their ligand preferences. Group I recognize (L/P)PXY motifs, where L=Leu, P=Pro, Y=Tyr, and X=any

Underlying Mechanisms of the Anti-inflammatory and Antioxidant Effects of Quercetin in Human Aortic Endothelial Cells : Implications for Vascular Inflammation and Atherosclerosis

Creator:: Li, Chuan
Abstract:: Atherosclerosis is the underlying cause of ischemic heart disease and stroke and is the leading cause of death worldwide, especially in developed countries. As an inflammatory disease of arteries in a hyperlipidemic milieu, expression of adhesion molecules, such as endothelial-leukocyte adhesion molecule-1 (E-selectin) and intercellular adhesion molecule-1 (ICAM-1), on endothelial...
Resource Type:: Dissertation
Full Text:: 2 (Nrf2) activation, increased mRNA and protein levels of heme oxygenase 1 (HO-1), NAD(P)H

The Role of Cellular Senescence in the Development of Alzheimer's Disease

Creator:: Riordan, Ruben
Abstract:: Alzheimer’s Disease (AD) is a neurodegenerative pathology currently affecting nearly 44 million individuals worldwide, yet there are not currently any effective treatments or preventions for AD despite the rapid development in our understanding of the disease over the last four decades. The medical and sanitary innovations of the last century...
Resource Type:: Dissertation
Full Text:: stressful conditions and activates transcription of various antioxidant proteins such as NAD(P)H:quinone

In vivo detoxification of acetic acid in Saccharomyces cerevisiae

Creator:: Ding, Jun
Abstract:: The studies described in this thesis were motivated by ongoing efforts to develop lignocellulosic biomass as an efficient and practical source of renewable energy. Enormous problems complicate these efforts to reduce reliance on greenhouse gas-generating fossil fuels. Simply obtaining the fermentable sugars available in the cellulose and hemicellulose components of...
Resource Type:: Dissertation
Full Text:: to pump cytosolic protons into the vacuole (Martínez- Muñoz and Kane 2008). By so doing, the V

Analysis of secondary structures in nucleic acid binding proteins and nuclear magnetic resonance investigation of helix propagation and residual motions in proteins

Creator:: Hicks, Joshua M.
Abstract:: This thesis involves analyses of 3₂-helices, a-helices and of the change in residual entropy of a protein upon chemical modification. Part of the long-term goal of understanding the formation, function and stability of proteins requires that all conformations be accurately assigned and structurally understood. By a statistical analysis of 258...
Resource Type:: Dissertation
Full Text:: and insight were greatly appreciated. I would also like to thank P. Andrew Karplus for critical

Voluntary alcohol consumption in male rhesus macaques suppresses cancellous bone remodeling

Creator:: Kahler-Quesada, Arianna M.
Abstract:: Background: Chronic heavy alcohol consumption is a risk factor for bone fracture. Using a non-human primate model of voluntary alcohol self-administration, we have recently shown that alcohol consumption suppresses intracortical bone remodeling. The current study extends this investigation to asses the effect of alcohol consumption on cancellous bone mass, architecture,...
Resource Type:: Honors College Thesis
Full Text:: architecture, and parameters of cancellous bone remodeling. Data analysis was conducted using SPSS. A p-value

Oxidative stress in amyotrophic lateral sclerosis : the role of cellular senescence and glutathione

Creator:: Beilby, Pamela R.
Abstract:: Amyotrophic lateral sclerosis (ALS) is a devastating neurological disorder characterized by neuromuscular junction decay, motor neuron death, progressive paralysis, and eventually death of the individual, usually by respiratory failure. Oxidative stress is a prominent hallmark of the disease and is often accompanied and exacerbated by mitochondrial dysfunction and neuroinflammation. This...
Resource Type:: Dissertation

Impaired epidermal homeostasis in Bcl11bR3S/R3S homozygous mutant mice

Creator:: Kelly, Avalon G.
Abstract:: BCL11B, also known as CTIP2, is a transcription factor which plays a critical role in the regulation and development of many tissues and organ systems, including the skin. A 2019 study by Goos et. al. uncovered a novel point mutation in BCL11B gene that converted the Arginine(R)-3 residue to a...
Resource Type:: Honors College Thesis
Full Text:: significantly decreased epidermal thickness in comparison with the wildtype (p<0.05, unpaired two-tailed t

Nucleoside diphosphokinase of Escherichia coli and its interactions with bacteriophage T4 proteins of DNA synthesis

Creator:: Ray, Nancy Bisset
Resource Type:: Dissertation
Full Text:: Sequencing (single-strand) 59 0. Overexpression of Recombinant NDPK 59 P. Purification of Overexpressed NDPK

Studies of genes expressed in the brain and regulated by transforming growth factor β

Creator:: Solem, Michele Lee
Resource Type:: Dissertation
Full Text:: mRNA of SFME grown in the presence of TGF p for 48 hours was differentially screened using cDNA

Protein-protein interactions in the bacteriophage T4 dNTP synthetase complex

Creator:: Shen, Rongkun
Abstract:: The enzymes of dNTP synthesis in T4 infection associate to form a multienzyme complex, the T4 dNTP synthetase complex, facilitating the flow of metabolites en route to dNTPs, and their subsequent flow into DNA. Study of protein-protein interactions helps one to understand how the enzymes in the complex are organized...
Resource Type:: Dissertation

Studies on the growth inhibition and differentiation of serum-free mouse embryo (SFME) cells

Creator:: Varga Weisz, Patrick D.
Abstract:: Serum-free mouse embryo (SFME) cells are derived in medium in which serum is replaced with growth factors and other supplements. They display unusual properties. They do not lose proliferative potential or show gross chromosomal aberration upon extended culture, they depend on epidermal growth factor (EGF) for survival, and are reversibly...
Resource Type:: Dissertation
Full Text:: Chemical Company, MO) and lysed by adding 0.5 t Nonidet P-40 (Sigma Chemical Company, MO). After brief

Organization of the T4 dNTP synthetase complex at DNA replication sites

Creator:: Kim, JuHyun
Abstract:: With respect to a multienzyme complex of deoxyribonucleoside triphosphate (dNTP) synthesis somehow juxtaposed with DNA replication sites, our laboratory has demonstrated the existence of a multienzyme complex in T4-infected E. coli, named the T4 dNTP synthetase complex, but the idea of direct linkage of dNTP synthesis to DNA replication and...
Resource Type:: Dissertation
Full Text:: ; Brush and Bessman, 1993; Teplyakov et al., 1996). 3 ADP UDP CI?P G?P Ribonucleotide reductase (RNR

The Creation of a Bilingual Children’s Book to Promote Mental Health Services among U.S. Latin@s

Creator:: Tolmach, Oresta S.
Abstract:: Although U.S. Latin@s are more affected by major depressive disorder than non-Latin@ whites, they are less likely to utilize mental health services. The purpose of this project is to create a children’s book that promotes the utilization of mental health services among U.S. Latin@s with major depressive disorder. This book...
Resource Type:: Honors College Thesis

On the location of the linker histones and the linker DNA in the 30 nm fiber of chromatin

Creator:: Leuba, Sanford H.
Abstract:: Understanding the structure of the 30 nm fiber in chromatin is relevant to understanding eukaryotic replication and transcription. The major controversy among the models of the fiber concerns the disposition of the linker DNA, the DNA between adjacent nucleosomes, and the location of the linker histones. To determine if the...
Resource Type:: Dissertation
Full Text:: phosphorylated lysines, histidines and arginines containing P-N linkages. P-N linkages were discovered in

Towards Resolving Functional and Evolutionary Mysteries of the Large and Heterozygous Genome of Hop (Humulus lupulus) and the Cannabaceae Family Using Genomic Data Science

Creator:: Padgitt-Cobb, Lillian K.
Abstract:: Hop (Humulus lupulus L. var. lupulus) is a diploid, dioecious plant with an extensive history of cultivation and use in brewing, as a textile, and for its therapeutic properties. Hop is prized for its ability to produce a variety of aromatic and flavor compounds, as well as compounds with anti-microbial...
Resource Type:: Dissertation
Full Text:: U.S. Pacific Northwest (PNW) was the result of a Cascade-adapted isolate of P. macularis [93]. Very

Towards a Better Understanding of How the Dietary Supplement Xanthohumol Can Improve Health

Creator:: Logan, Isabelle E.
Abstract:: Xanthohumol, a prenylated flavonoid found in hops and beer, possesses a long-standing reputation to improve health. Xanthohumol’s cytotoxicity to a wide variety of cancer cell lines is well-established. Herein we provide further insight into the cytotoxicity of not only xanthohumol, but also its non-estrogenic derivatives, to a number of colonic...
Resource Type:: Dissertation
Full Text:: , Stephany Vasquez-Perez, Jaewoo Choi, Joyce P. Kim, and Malcolm Lowry contributed to experimental design

Viral Targeting of Host Hubs: Interactions between the Rabies Virus and LC8

Creator:: Jespersen, Nathan E.
Abstract:: As obligate intracellular parasites, viruses rely on host machinery for their own reproduction. Viruses are therefore required to interact with a wide variety of host proteins, despite limitations in viral genome size. The most parsimonious method of success is to hijack central and essential proteins, known as hub proteins. LC8...
Resource Type:: Dissertation
Full Text:: frequently referred to as the phosphoprotein (P). In numerous Mononegavirales, such as the Nipah virus

Nonsenecent serum-free mouse proastroblasts : extended culture, growth responses in vitro, and application to the culture of human embryonic astrocytes

Creator:: Loo, Deryk Thomas
Abstract:: Mouse embryo cells cultured in vitro in serum-supplemented media undergo growth crisis, resulting in the loss of genomically normal cells prior to the appearance of established, aneuploid cell lines. I used the technique of serum-free cell culture to develop a serum-free mouse embryo (SFME) cell line in which serum was...
Resource Type:: Dissertation

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