Index Catalog // ScholarsArchive@OSU

Age-related decrease in resilience against acute redox cycling agents: Critical role of declining GSH-dependent detoxification capacity

Creator:: Thomas, Nicholas O.
Abstract:: Over the past century, life expectancy in the United States has dramatically increased leading to an increasingly aging population with people reaching, and spending more years in ‘old age’. While this unprecedented shift in population demographics represents great strides for humanity, it is not without cost. One consequence of longer...
Resource Type:: Dissertation

The analysis of kisspeptin neuronal exosomes and their effects on neuronal plasticity of downstream gonadotropin-releasing hormone expressing neurons

Creator:: Ewton, Jessica
Abstract:: Gonadotropin-releasing hormone (GnRH) neurons are able to trigger the release of luteinizing hormone and follicle-stimulating hormone which control the maturation of oocytes and ovulation which is vital for reproduction. They are the most downstream neurons that project to the median eminence into the pituitary portal where they release GnRH. Modulation...
Resource Type:: Honors College Thesis
Full Text:: Academy of Sciences 2010, 107 (52), 22693–22698. https://doi.org/10.1073/pnas.1012406108. 21. Matesic, D

The role of sigma factors in production of cyanobacterial natural products: Escherichia coli as a heterologous expression host

Creator:: Wells, Kaitlyn N.
Abstract:: Cyanobacteria represent an underexploited source of bioactive natural products of interest to the pharmaceutical industry. Lack of development of these compounds as drug leads is due mainly to myriad practical problems with the producing strains including long doubling times, genetic intractability, and low compound yields. Previous attempts at heterologous expression...
Resource Type:: Honors College Thesis
Full Text:: nonribosomal pathway. Proc Natl Acad Sci U S A 111:E1909−E1917. 10.1073/pnas.1320913111. 26 16

Towards a Better Understanding of How the Dietary Supplement Xanthohumol Can Improve Health

Creator:: Logan, Isabelle E.
Abstract:: Xanthohumol, a prenylated flavonoid found in hops and beer, possesses a long-standing reputation to improve health. Xanthohumol’s cytotoxicity to a wide variety of cancer cell lines is well-established. Herein we provide further insight into the cytotoxicity of not only xanthohumol, but also its non-estrogenic derivatives, to a number of colonic...
Resource Type:: Dissertation

Examining the Human Relevance of a New Mouse Model of ALS and Observations on the Incidence in Human Populations

Creator:: Winkenbach, Lindsay
Abstract:: Amyotrophic Lateral Sclerosis (ALS) is a relatively rare neurodegenerative disorder that is fatal 2-4 years after the onset of the disease. Population studies are being done in order to help reveal candidates for further studies of disease etiology, disease progression, as well as to further understand racial and ethnic variations....
Resource Type:: Honors College Thesis
Full Text:: ):6072-6077. doi:10.1073/pnas.0610923104. 27. Jaarsma D, Haasdijk ED, Grashorn JA, et al. Human Cu/Zn

In vivo Reactions of Tetrazines Incorporated through Genetic Code Expansion

Creator:: Blizzard, Robert J.
Abstract:: The inverse electron demand Diels Alder reaction between tetrazines and strained alkenes is an exceptionally useful tool in functionalizing to biomolecules since it is orthogonal to the chemistry of most living systems and have exceptionally high rate constants. In particular reactions between strained trans-cyclooctenes (sTCO) and tetrazines can achieve second...
Resource Type:: Dissertation

The Role of Cellular Senescence in the Development of Alzheimer's Disease

Creator:: Riordan, Ruben
Abstract:: Alzheimer’s Disease (AD) is a neurodegenerative pathology currently affecting nearly 44 million individuals worldwide, yet there are not currently any effective treatments or preventions for AD despite the rapid development in our understanding of the disease over the last four decades. The medical and sanitary innovations of the last century...
Resource Type:: Dissertation

Context matters : assembly and disorder in the regulation of multivalent complexes

Creator:: Jara, Kayla A.
Abstract:: Intrinsically disordered proteins (IDPs), protein regions (IDRs), and protein complexes continue to emerge at the forefront of protein science. Proteins and protein regions lacking specific structure are found in all organisms, and often have vital roles in numerous biological processes. Breaking the well-known structure-function paradigm, the understanding of disorder-based functionality...
Resource Type:: Dissertation

Initial in vitro and in vivo Characterization of the Membrane Trafficking Protein Fer1L6

Creator:: Wolk, Chelsea
Abstract:: A fundamental difference between prokaryotic and eukaryotic cells is the presence of membrane bound organelles in eukaryotes. The dynamics of membrane trafficking within the cell are responsible for everything from intercellular communication and cell homeostasis, to mitosis, cell migration, and differentiation. These processes require exocytosis and compensatory endocytosis, often working...
Resource Type:: Dissertation

Specificity, Allostery, and Multivalency in Binding to the Hub Protein LC8

Creator:: Estelle, Aidan B.
Abstract:: Interactions between proteins are essential to life, driving and regulating a majority of processes within all living cells. Study of protein-protein interactions reveals that some proteins act as hubs within networks of interactions, binding to many partner proteins. These hubs therefore are of particular importance to understanding protein function, interwoven...
Resource Type:: Dissertation

ScholarsArchive@OSU

Age-related decrease in resilience against acute redox cycling agents: Critical role of declining GSH-dependent detoxification capacity

The analysis of kisspeptin neuronal exosomes and their effects on neuronal plasticity of downstream gonadotropin-releasing hormone expressing neurons

The role of sigma factors in production of cyanobacterial natural products: Escherichia coli as a heterologous expression host

Towards a Better Understanding of How the Dietary Supplement Xanthohumol Can Improve Health

Examining the Human Relevance of a New Mouse Model of ALS and Observations on the Incidence in Human Populations

In vivo Reactions of Tetrazines Incorporated through Genetic Code Expansion

The Role of Cellular Senescence in the Development of Alzheimer's Disease

Context matters : assembly and disorder in the regulation of multivalent complexes

Initial in vitro and in vivo Characterization of the Membrane Trafficking Protein Fer1L6

Specificity, Allostery, and Multivalency in Binding to the Hub Protein LC8

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