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Filtering by: Creator Baio, Andrew Degree Field Biochemistry and Biophysics

Conformational Consequences: Calcium Regulates the Association Between Dysferlin C2A & PI(4,5)P2

Creator:

Otto, Shauna C.

Abstract:

Dysferlin is a ∼230 kDa terminally anchored membrane protein that is ubiquitously expressed, but is particularly enriched in skeletal and cardiac muscle tissue. Mutations covering the length of the protein have been linked to muscle wasting diseases including limb-girdle muscular dystrophy and Myoshi myopathy. Dysferlin has been shown to play...

Resource Type:

Dissertation

Full Text:

roadblocks. I also thank my graduate committee, Dr. Elisar Barbar, Dr. Patrick Reardon, Dr. Joe Baio, and Dr
Characterizing the Functional Properties of Otoferlin, Essential for Neurotransmission in Inner Hair Cells of the Cochlea

Creator:

Narayanappa, Murugesh

Abstract:

Hearing loss is one of the most common defect, affecting 360 million people worldwide due to several factors including congenital, present at or soon after birth or acquired with age. Congenital hearing loss affects 32 million children in the world. The economic impact of hearing loss is estimated to cost...

Resource Type:

Dissertation

Full Text:

Henson, Andrew Bereton, Arden Perkins, Robbert Blizzard, Steve Friedman, Bharath Sunchu, Akash