Index Catalog // ScholarsArchive@OSU

Alkylation kinetics of the human retinoid X receptor α using cysteine as a local probe

Creator:: Vanegas, Juan Manuel
Abstract:: The unfolding of human retinoid X receptor α in the presence of the denaturant guanidine HCl was studied using stopped-flow absorbance spectroscopy. The protein's four native cysteine residues were mutated to obtain four single-cysteine mutants, each with the other three cysteine residues mutated to alanine. The thiols of these hRXRα...
Resource Type:: Masters Thesis
Full Text:: of the protein. Circular dichroism and tryptophan fluorescence emission were used to determine

Crystallographic studies of Pyrenophora tritici-repentis ToxA

Creator:: Sarma, Ganapathy N.
Abstract:: Tan spot of wheat is an economically significant disease caused by the fungal pathogen, Pyrenophora tritici-repentis. Certain races of the fungus secrete Ptr ToxA (ToxA), a 13.2 kDa proteinaceous host-selective toxin that is responsible and sufficient to cause disease in susceptible wheat varieties. Disease symptoms develop only when the ToxA...
Resource Type:: Dissertation
Full Text:: activity. Unexpectedly, after a simple circular permutation, Redacted for privacy the ToxA structure is

The 2-μm Plasmid of Saccharomyces cerevisiae; Partial Characterization of a Eukaryotic Minichromosome

Creator:: Zsebo, Krisztina Maria
Resource Type:: Masters Thesis
Full Text:: - 100 copies per cell of a circular plasmid which comprises about 4% of the total yeast DNA. It has

Characterization of Fer1L6 in the mouse C2C12 cell line

Creator:: Huegel, Jacob T.
Abstract:: Fer1L6 is an uncharacterized member of the ferlin family of proteins, a group of large, calcium sensitive proteins with emerging roles in vesicle trafficking and various disease states. The presence of Fer1L6 has been identified within the C2C12 cell line of mouse skeletal muscle. To determine the protein’s subcellular location...
Resource Type:: Honors College Thesis
Full Text:: each other their oligonucleotides will ligate together and undergo circular a circular polymerase

Adenovirus complementary strand synthesis in vivo

Creator:: Wang, Kai, 1955-
Abstract:: Replication of plasmid molecules containing a single adenovirus terminal sequence and specially arranged inverted repeat sequences were studied. When the plasmids were linearized to expose the adenovirus terminal sequence and transfected into 293 cells with helper adenovirus DNA, a larger molecule was detected. The new molecule contained adenovirus terminal sequences...
Resource Type:: Dissertation
Full Text:: expose the adenovirus terminus. Neither circular plasmids containing the same adenovirus origin nor

Characterizing the Functional Properties of Otoferlin, Essential for Neurotransmission in Inner Hair Cells of the Cochlea

Creator:: Narayanappa, Murugesh
Abstract:: Hearing loss is one of the most common defect, affecting 360 million people worldwide due to several factors including congenital, present at or soon after birth or acquired with age. Congenital hearing loss affects 32 million children in the world. The economic impact of hearing loss is estimated to cost...
Resource Type:: Dissertation
Full Text:: ............................................................................................. 92 4.3.6. Circular Dichroism

Biophysical basis of macromolecular assembly in the dynein cargo attachment complex

Creator:: Hall, Justin Daniel
Abstract:: Cytoplasmic dynein is an ATP-dependent, microtubule-based molecular motor involved in the positioning and trafficking of cellular cargo. The cargo binding sub-domain of dynein contains the natively disordered intermediate chain (IC) and the homodimeric light chains (Tctex1, LC8 and LC7). The structure and stoichiometry of this complex, how the light chains...
Resource Type:: Dissertation
Full Text:: -IC, residues 1-289 in D. melanogaster) (Makokha et al. 2002; Nyarko et al. 2004) followed by a

Mechanism of action of Escherichia coli uracil-DNA glycosylase and interaction with the bacteriophage PBS-2 uracil-DNA glycosylase inhibitor protein

Creator:: Lundquist, Amy J.
Resource Type:: Dissertation
Full Text:: displayed a processive mechanism when analyzed using either covalently-closed circular duplex DNA substrate

Characterization of the SARS-CoV-2 Nucleocapsid Protein and the Binding to Different Sections of the SARS-CoV-2 Genome

Creator:: Pinckney, Seth H.
Abstract:: The nucleocapsid protein (N protein) of the severe acute respiratory syndrome coronavirus 2 is known to play an essential part of the virus’ functions. The N protein can protect and package the large 29,903 nucleotide genomic RNA whilst also interacting with structural membrane protein M and the spike protein S....
Resource Type:: Honors College Thesis
Full Text:: ). Circular dichroism Spectra were recorded on a JASCO 720 spectropolarimeter (Jasco, Oklahoma City, OK

Endocrine control of proteolysis in cultured muscle cells

Creator:: Hong, Dong-Hyun
Resource Type:: Dissertation
Full Text:: . Mildner, P. and B. Ries. Oxford, U.K. Pergamon, pp. 289-306 Jefferson, L. S., J. B. Li and S. R

ScholarsArchive@OSU

Alkylation kinetics of the human retinoid X receptor α using cysteine as a local probe

Crystallographic studies of Pyrenophora tritici-repentis ToxA

The 2-μm Plasmid of Saccharomyces cerevisiae; Partial Characterization of a Eukaryotic Minichromosome

Characterization of Fer1L6 in the mouse C2C12 cell line

Adenovirus complementary strand synthesis in vivo

Characterizing the Functional Properties of Otoferlin, Essential for Neurotransmission in Inner Hair Cells of the Cochlea

Biophysical basis of macromolecular assembly in the dynein cargo attachment complex

Mechanism of action of Escherichia coli uracil-DNA glycosylase and interaction with the bacteriophage PBS-2 uracil-DNA glycosylase inhibitor protein

Characterization of the SARS-CoV-2 Nucleocapsid Protein and the Binding to Different Sections of the SARS-CoV-2 Genome

Endocrine control of proteolysis in cultured muscle cells

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