Index Catalog // ScholarsArchive@OSU

Dietary organosulfur and organoselenium compounds as HDAC inhibitors

Creator:: Nian, Hui
Abstract:: Histone deacetylase (HDAC) inhibitors have the potential to de-repress epigenetically silenced genes in cancer cells, leading to cell cycle arrest and apoptosis. Dietary HDAC inhibitors derived from natural phytochemicals are promising anticancer agents. In this thesis, metabolites from natural organosulfur and organoselenium compounds, i.e. allyl mercaptan (AM), β-methylselenopyruvate (MSP) and...
Resource Type:: Dissertation

Characterization of the Zea mays ssp. mays TOUSLED-like kinases

Creator:: Owusu, Ethel Owusuwaa
Abstract:: This dissertation describes the cloning and characterization of the TOUSLEDlike kinases genes of maize (ZmTLKs). The TOUSLED-like kinases (TLKs) are a conserved family of nuclear Ser/Thr kinases in higher eukaryotes. The maize genome has three TOUSLED-like kinase genes (ZmTLK1, ZmTLK2, and ZmTLK3). Based upon sequence similarity, the ZmTLKs are divided...
Resource Type:: Dissertation

Characterization of neuronal nitric-oxide synthase reductase activity

Creator:: Wolthers, Kirsten R.
Abstract:: During catalysis the flavoprotein domain of neuronal nitric-oxide synthase (nNOS) shuttles NADPH-derived reducing equivalents from FAD to FMN and then to the P450-heme enabling heme-based oxygen activation and subsequent NO-synthesis. The binding of Ca²⁺-activated calmodulin (Ca²⁺-CaM) to nNOS alleviates inhibition of flavin mediated electron transfer within the diflavin domain, which...
Resource Type:: Dissertation
Full Text:: isozymes, the nitric-oxide synthases (NOS; EC 1.14.13.39), catalyze NO biosynthesis via the five-electron

Identification of a compound series by high throughput screening capable of reversing the antiviral effect of Ribavirin in tissue culture

Creator:: Gallion, Jonathan
Abstract:: A compound series capable of reversing the antiviral effect of Ribavirin (RBV) against H1N1 was identified from a high throughput screen designed to discover compounds capable of increasing the fidelity of the RNA-dependent RNA polymerase (RDRP) n ribovirus quasispecies. Two lead compounds, RIC-1 (EC50 of 78.4 nM) and RIC-2 (EC50...
Resource Type:: Honors College Thesis
Full Text:: the EC plates was determined from NA activity on 4- MUNANA. Tertiary Screen assay development

The microtubule system and the canalicular mdr2 P-glycoprotein play a role in the intracellular transport and biliary secretion of α-Tocopherol and phosphatidylcholine in rats and mice

Creator:: Mustacich, Debbie J.
Resource Type:: Dissertation

Characterization of the Escherichia coli uracil-DNA glycosylase- inhibitor protein interaction

Creator:: Bennett, Samuel E.
Resource Type:: Dissertation
Full Text:: E. coli deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase, EC 3.6.1.23) plays a central role

Organization of T4 bacteriophage genes and gene products involved in DNA precursor biosynthesis

Creator:: Wang, Yeong
Abstract:: Bacteriophage T4 gene 42 encodes dCMP hydroxymethylase, an enzyme unique to the deoxyribonucleotide metabolism of T-even bacteriophages. To study biochemical and biophysical properties of the enzyme, as well as the interaction of dCMP hydroxymethylase with other DNA precursor biosynthetic enzymes in vitro, availability of large amounts of the enzyme is...
Resource Type:: Dissertation
Full Text:: ). Dihydrofolate reductase, like thymidylate synthase, is a phage- thief d oat n C Impose EC 3 1.4.5 DNA

Alternatives to the DNA precursor-synthesizing enzyme complex hypothesis

Creator:: Weitz, Stephen L.
Abstract:: Investigators have been studying an aggregate containing enzymes of deoxyribonucleoside triphosphate biosynthesis in T4-phage infected bacteria. They suggest that it behaves as an organized complex, efficiently channeling DNA precursors to the replication apparatus. Previous work has suggested that about 10 enzyme activities remain associated through several fractionation steps. This multi-enzyme...
Resource Type:: Dissertation
Full Text:: it and the cellular dCTP deaminase display moonier:se EC DNA polymoroso EC \ dCMP

Bacteriophage T4-coded dihydrofolate reductase : cloning and structural analysis of its gene and organization of flanking regions

Creator:: Purohit, Sarla
Abstract:: The dihydrofolate reductase gene of bacteriophate T4 has been investigated at the structural level to elucide the unusual regulation of expression of this gene and possible evolutionary relationships between the ohage and drug resistance factors-encoded dihydrofolate reductases (DHFR). A 1.1-kilobase-pair restriction fragment of the T4 multiple mutant dec8 containing frd,...
Resource Type:: Dissertation
Full Text:: deoxycytidylate hydroxymethylase (HMase; EC. 2.1.2.b) be- longs to this second category and functions in the

Selenium metabolism in the chick and effects of Vitamin E and selenium on heat stress

Creator:: Alayan, Mohammad Atta
Abstract:: An in vitro study was conducted to investigate the metabolism and distribution of Se⁷⁵-selenite and Se⁷⁵-selenomethionine (SEM) in chick blood. Se⁷⁵-selenite is taken up by RBC (13% within 20 minutes) and expelled into the plasma to become bound to proteins. In contrast, Se⁷⁵-SEM showed a more gradual and continuous buildup...
Resource Type:: Masters Thesis
Full Text:: -deficient chick. J. Nutr. 110:743-749. CHAPTER III 17 In Vitro Metabolism of Se 75 -Selenite and Se75

ScholarsArchive@OSU

Dietary organosulfur and organoselenium compounds as HDAC inhibitors

Characterization of the Zea mays ssp. mays TOUSLED-like kinases

Characterization of neuronal nitric-oxide synthase reductase activity

Identification of a compound series by high throughput screening capable of reversing the antiviral effect of Ribavirin in tissue culture

The microtubule system and the canalicular mdr2 P-glycoprotein play a role in the intracellular transport and biliary secretion of α-Tocopherol and phosphatidylcholine in rats and mice

Characterization of the Escherichia coli uracil-DNA glycosylase- inhibitor protein interaction

Organization of T4 bacteriophage genes and gene products involved in DNA precursor biosynthesis

Alternatives to the DNA precursor-synthesizing enzyme complex hypothesis

Bacteriophage T4-coded dihydrofolate reductase : cloning and structural analysis of its gene and organization of flanking regions

Selenium metabolism in the chick and effects of Vitamin E and selenium on heat stress

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