Index Catalog // ScholarsArchive@OSU

Age-related decrease in resilience against acute redox cycling agents: Critical role of declining GSH-dependent detoxification capacity

Creator:: Thomas, Nicholas O.
Abstract:: Over the past century, life expectancy in the United States has dramatically increased leading to an increasingly aging population with people reaching, and spending more years in ‘old age’. While this unprecedented shift in population demographics represents great strides for humanity, it is not without cost. One consequence of longer...
Resource Type:: Dissertation

Cytoskeletal regulation in cell motility and invasion

Creator:: Jang, Hyo Sang
Abstract:: Cell motility and invasion are important for development, immunity, wound healing, and tumor cell metastasis. Cells on two dimensional substrates migrate in three steps: protrusion of the front end, translocation of the cell body, and retraction of the rear end. For cells to migrate efficiently, these steps need to be...
Resource Type:: Dissertation

Characterization of the Zea mays ssp. mays TOUSLED-like kinases

Creator:: Owusu, Ethel Owusuwaa
Abstract:: This dissertation describes the cloning and characterization of the TOUSLEDlike kinases genes of maize (ZmTLKs). The TOUSLED-like kinases (TLKs) are a conserved family of nuclear Ser/Thr kinases in higher eukaryotes. The maize genome has three TOUSLED-like kinase genes (ZmTLK1, ZmTLK2, and ZmTLK3). Based upon sequence similarity, the ZmTLKs are divided...
Resource Type:: Dissertation

Characterization of neuronal nitric-oxide synthase reductase activity

Creator:: Wolthers, Kirsten R.
Abstract:: During catalysis the flavoprotein domain of neuronal nitric-oxide synthase (nNOS) shuttles NADPH-derived reducing equivalents from FAD to FMN and then to the P450-heme enabling heme-based oxygen activation and subsequent NO-synthesis. The binding of Ca²⁺-activated calmodulin (Ca²⁺-CaM) to nNOS alleviates inhibition of flavin mediated electron transfer within the diflavin domain, which...
Resource Type:: Dissertation
Full Text:: isozymes, the nitric-oxide synthases (NOS; EC 1.14.13.39), catalyze NO biosynthesis via the five-electron

Expression and G protein coupling of the M2 muscarinic acetylcholine receptor in Sf9 insect cells

Creator:: Mosser, Valerie A.
Resource Type:: Dissertation

Site-directed mutagenesis of the m2 muscarinic acetylcholine receptor

Creator:: Vogel, Walter Kevin
Resource Type:: Dissertation

Protein methylation at sites of blood vessel injury

Creator:: Weber, Darin J.
Abstract:: Blood vessel injury was found to release intracellular pools of protein D-aspartyl/L-isoaspartyl carboxyl methyltransferase (PIMT) into the extracellular milieu, where it became trapped. Trapped PIMT was able to utilize radiolabeled S-adenosyl-L-methionine (AdoMet) introduced into the circulation to methylate blood vessel proteins containing altered aspartyl residues specifically at the site of...
Resource Type:: Dissertation
Full Text:: methyltransferase (EC 2.1.1.77) purified from rabbit erythrocytes (Gilbert et al. 1988) was added to the assay

Vaccinia virus ribonucleotide reductase : regulation of the gene products and characterization of the recombinant small subunit protein

Creator:: Howell, Meredith L.
Abstract:: Ribonucleotide reductase is a remarkable enzyme that catalyzes the rate-limiting step in the synthesis of the 2'-deoxynucleoside triphosphates. The intent of this project was to characterize the ribonucleotide reductase encoded by the orthopoxvirus, vaccinia. The first objective was to study the structural and functional features of the viral small subunit...
Resource Type:: Dissertation

Regulation of phosphofructokinase by reversible inactivation

Creator:: Zhao, Zhizhuang
Abstract:: The interaction of skeletal muscle phosphofructokinase with a variety of acidic proteins including calmodulin and troponin C and with nucleic acids (RNA and DNA) is manifest in a reversible, time-dependent loss of catalytic activity. The inactivation is affected by a number of factors. Substrates (fructose-6-phosphate and ATP), positive effectors (fructose-2,6-bisphosphate,...
Resource Type:: Dissertation
Full Text:: phosphofructokinase (PFK, ATP:D-fructose- 6-phosphate - 1 - phosphotransferase, EC 2. 7. 1. 11) is a key glycolytic

Rapid kinetic studies of thymidylate synthase

Creator:: Mittelstaedt, Denice
Resource Type:: Dissertation
Full Text:: 25° 768 ± 371 610 ± 400 19.0 21.5 t 3.2 30° dUMP 233 ± 15 81.3 ± 18 0.9 2.5 t 0.7 10° 188 t 81 62

ScholarsArchive@OSU

Age-related decrease in resilience against acute redox cycling agents: Critical role of declining GSH-dependent detoxification capacity

Cytoskeletal regulation in cell motility and invasion

Characterization of the Zea mays ssp. mays TOUSLED-like kinases

Characterization of neuronal nitric-oxide synthase reductase activity

Expression and G protein coupling of the M2 muscarinic acetylcholine receptor in Sf9 insect cells

Site-directed mutagenesis of the m2 muscarinic acetylcholine receptor

Protein methylation at sites of blood vessel injury

Vaccinia virus ribonucleotide reductase : regulation of the gene products and characterization of the recombinant small subunit protein

Regulation of phosphofructokinase by reversible inactivation

Rapid kinetic studies of thymidylate synthase

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