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Filtering by: Creator Fujita, Rod Remove constraint Creator: Fujita, Rod Degree Field Biochemistry and Biophysics Remove constraint Degree Field: Biochemistry and Biophysics

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  • Analysis of ras gene mutations in rainbow trout tumors

    Creator:
    Chang, Yung-jin
    Abstract:
    For ras gene mutation analysis in the rainbow trout (Oncorhynchus mykiss) model system, a partial trout ras sequence was identified using the polymerase chain reaction (PCR). Two synthetic oligonucleotides based on rat K-ras gene sequence were used as primers for the PCR procedure. A 90 base pair (bp) sequence, referred...
    Resource Type:
    Dissertation
    Full Text:
    , David Williams, Rod Dashwood, Mark Daeschel, Christopher Mathews. Lab colleagues, Dan Arbogast, Jean

  • Cytoskeletal regulation in cell motility and invasion

    Creator:
    Jang, Hyo Sang
    Abstract:
    Cell motility and invasion are important for development, immunity, wound healing, and tumor cell metastasis. Cells on two dimensional substrates migrate in three steps: protrusion of the front end, translocation of the cell body, and retraction of the rear end. For cells to migrate efficiently, these steps need to be...
    Resource Type:
    Dissertation
    Full Text:
    -terminal rod domain (Rod). Vinculin binds to the SLR of α-actinin or the talin Rod domain via the N

  • Building a bridge from chromosomes to microtubules in Neurospora crassa

    Creator:
    Friedman, Steven
    Abstract:
    DNA is often described as the “blueprint for life”. In eukaryotes this information is contained within linear chromosomes of varying size and number. During cell division, the chromosomes must be faithfully segregated into each daughter cell to avoid disease and sustain life. This process is carried out by the kinetochore...
    Resource Type:
    Dissertation

  • Antioxidant mechanisms of ascorbate and (R)-α-lipoic acid in aging and transition metal ion-mediated oxidative stress

    Creator:
    Shu, Jung Hyuk
    Abstract:
    Oxidative stress is the major driving force behind the aging process and many age-related diseases. However, direct experimental evidence of whether antioxidants, such as ascorbate (AA) and lipoic acid (LA) can slow the progression of aging process and/or reduce risks of developing degenerative disease is largely absent. This suggests a...
    Resource Type:
    Dissertation

  • Transcriptional regulation of the human cathelicidin antimicrobial peptide gene

    Creator:
    Guo, Chunxiao
    Abstract:
    Human cathelicidin antimicrobial peptide (CAMP/LL-37) is a cationic antimicrobial peptide that is widely expressed by myeloid and epithelial cells at the human-environment interface. It possesses broad spectrum antimicrobial capacity against bacteria, fungi and viruses. In addition to its direct antimicrobial activity, CAMP/LL-37 also attracts and recruits monocytes, neutrophils and other...
    Resource Type:
    Dissertation