Index Catalog // ScholarsArchive@OSU

Studies on the inhibition of bovine plasma amine oxidase by hydrazines

Creator:: Hucko-Haas, Jacqueline Elizabeth
Abstract:: Several aspects of the potent inhibition of bovine plasma amine oxidase (PAO) by hydrazines were investigated by kinetic and preparative means. The inhibition was classified as pseudo-irreversible by the method of Ackerman and Potter (Proc. Soc. Exptl. Biol. Med. 72, 1 (1949), and was found to exhibit Zone B kinetic...
Resource Type:: Dissertation
Full Text:: Privacy Dr. Donald J. Reed Several aspects of the potent inhibition of bovine plasma amine oxidase (PAO

The oxidative demethylation of certain N-methylhydrazines by microsomal liver enzymes

Creator:: Wittkop, Judith Anne
Abstract:: The presence in rat liver microsomes of an enzyme system which demethylates N-methylhydrazines and azo compounds to formaldehyde has been reported. Some of the compounds found to be substrates were monomethylhydrazine, N-isopropyl-α-(2-methylhydrazino)- p-toluamide and the azo derivative of the latter hydrazine. This enzyme can be classified as a mixed function...
Resource Type:: Dissertation
Full Text:: CERTAIN N-METHYLHYDRAZINES BY MICROSOMAL LIVER ENZYMES Abstract approved: Redacted for Privacy Donald

The conversion of some monoalkylhydrazines to their corresponding hydrocarbons by a hepatic microsomal enzyme system in rat

Creator:: Prough, Russell A.
Abstract:: An aspect of the metabolism of monoalkylhydrazines has been investigated using both intact rats and rat liver microsomal enzyme preparations. Intact rats respired propane and n-butane on administration of 0.3-0.5 mmoles of isopropyl- and n-butylhydrazine, respectively. Based upon dose administered, a five to ten percent yield of hydrocarbon was obtained....
Resource Type:: Dissertation
Full Text:: A HEPATIC MICROSOMAL ENZYME SYSTEM IN RAT Redacted for Privacy Abstract approved: Donald Reed An

Analysis of cytochrome P-450 isozymes from rat liver and studies on the mechanism of induction

Creator:: Williams, David Edward
Abstract:: In order to determine the total number of cytochrome P-450 isozymes present in a given species following various treatments, mature male rats (Sprague-Dawley) were injected intraperitoneally with the classic mixed-function oxidase inducers phenobarbital (PB), pregnenolone- 16a-carbonitrile (PCN), 3-methylcholanthrene (3-MC), or the appropriate control vehicle. Hepatic microsomes were solubilized and P-450...
Resource Type:: Masters Thesis
Full Text:: Abstract approved: Dr. Donald J. Reed In order to determine the total number of cytochrome P-450 iso

Metabolic pathway of the nitrosoureas catalyzed by cytochrome P-450 and NADPH cytochrome P-450 reductase

Creator:: Potter, David Willard
Abstract:: Three highly purified forms of cytochrome P-450 (P-450a, P-450b, P-450c) from Aroclor 1254-induced rat hepatic microsomes catalyzed the monooxygenation of 1-(2- chloroethyl)-3-(trans-4-methylcyclohexyl)-1-nitrosourea (MeCCNU) and 1-(2-chloroethyl)-3-(cyclohexyl)-1-nitrosourea (CCNU) in the presence of purified NADPH cytochrome P-450 reductase, NADPH and oxygen. Cytochrome P -450- dependent monooxygenation of CCNU gave six alicyclic hydroxylation products...
Resource Type:: Dissertation
Full Text:: Donald J. Reed for his patience and support during my stay as a graduate student in his laboratory

Studies on the glutathione dependent protection of the cell nucleus against lipid peroxidation

Creator:: Tirmenstein, Mark A.
Abstract:: Lipid peroxidation is believed to be an important process in the development of cellular injury. In addition to the degradation of biological membranes, increasing evidence indicates that lipid peroxidation can alter the structure and function of DMA. The present study examines the peroxidation of nuclear membranes and the capacity of...
Resource Type:: Dissertation
Full Text:: approved: Redacted for Privacy Donald J. Reed Lipid peroxidation is believed to be an important process

Mitochondrial glutathione and the effect of perturbed calcium homeostasis on rat hepatocyte thiols

Creator:: Olafsdottir, Kristin
Abstract:: Recent studies have demonstrated that perturbations of intracellular thiol and calcium homeostasis may be important events in the early development of cell injury by toxic chemicals. Incubation of isolated rat hepatocytes in a calcium free medium, severely depleted intracellular Ca²⁺ levels and resulted in the loss of both cytosolic and...
Resource Type:: Dissertation
Full Text:: Olafsdottir ACKNOWLEDGEMENTS I would like to express my gratitude to my advisor, Dr. Donald J. Reed, for

Glutathione conjugation as a determinant in 1,2-dihaloethane and alpha-naphthylisothiocyanate toxicity

Creator:: Jean, Paul A.
Resource Type:: Dissertation
Full Text:: . Abstract approved: Redacted for Privacy Ddnald J. Reed, Ph.D. Glutathione, a ubiquitous cellular

The microtubule system and the canalicular mdr2 P-glycoprotein play a role in the intracellular transport and biliary secretion of α-Tocopherol and phosphatidylcholine in rats and mice

Creator:: Mustacich, Debbie J.
Resource Type:: Dissertation
Full Text:: my major professor and mentor, Dr. Donald J. Reed, for his guidance and support, both personally and

Use of γ-Glutamyltranspeptidase-deficient knockout mice as a model to study the relationship between glutathione status, mitochondrial dysfunction, and cell death

Creator:: Will, Yvonne
Resource Type:: Dissertation
Full Text:: , and Cell Death. Abstract approved: Donald J. Reed Glutathione is a major protective molecule

ScholarsArchive@OSU

Studies on the inhibition of bovine plasma amine oxidase by hydrazines

The oxidative demethylation of certain N-methylhydrazines by microsomal liver enzymes

The conversion of some monoalkylhydrazines to their corresponding hydrocarbons by a hepatic microsomal enzyme system in rat

Analysis of cytochrome P-450 isozymes from rat liver and studies on the mechanism of induction

Metabolic pathway of the nitrosoureas catalyzed by cytochrome P-450 and NADPH cytochrome P-450 reductase

Studies on the glutathione dependent protection of the cell nucleus against lipid peroxidation

Mitochondrial glutathione and the effect of perturbed calcium homeostasis on rat hepatocyte thiols

Glutathione conjugation as a determinant in 1,2-dihaloethane and alpha-naphthylisothiocyanate toxicity

The microtubule system and the canalicular mdr2 P-glycoprotein play a role in the intracellular transport and biliary secretion of α-Tocopherol and phosphatidylcholine in rats and mice

Use of γ-Glutamyltranspeptidase-deficient knockout mice as a model to study the relationship between glutathione status, mitochondrial dysfunction, and cell death

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