Index Catalog // ScholarsArchive@OSU

Examining the Human Relevance of a New Mouse Model of ALS and Observations on the Incidence in Human Populations

Creator:: Winkenbach, Lindsay
Abstract:: Amyotrophic Lateral Sclerosis (ALS) is a relatively rare neurodegenerative disorder that is fatal 2-4 years after the onset of the disease. Population studies are being done in order to help reveal candidates for further studies of disease etiology, disease progression, as well as to further understand racial and ethnic variations....
Resource Type:: Honors College Thesis
Full Text:: : ______________________________________________________ Joseph Beckman Amyotrophic Lateral Sclerosis (ALS) is a relatively rare

Oxidative stress in amyotrophic lateral sclerosis : the role of cellular senescence and glutathione

Creator:: Beilby, Pamela R.
Abstract:: Amyotrophic lateral sclerosis (ALS) is a devastating neurological disorder characterized by neuromuscular junction decay, motor neuron death, progressive paralysis, and eventually death of the individual, usually by respiratory failure. Oxidative stress is a prominent hallmark of the disease and is often accompanied and exacerbated by mitochondrial dysfunction and neuroinflammation. This...
Resource Type:: Dissertation
Full Text:: : Joseph S. Beckman Amyotrophic lateral sclerosis (ALS) is a devastating neurological disorder

Structural studies of the antioxidant defense enzymes; copper, zinc superoxide dismutase and alkyl hydroperoxide reductase flavoprotein

Creator:: Roberts, Blaine R.
Abstract:: Oxygen derived radicals are involved in many aspects of life from aging and cell signaling to disease states as diverse as heart disease, diabetes, neurodegeneration and inflammation. Therefore, understanding the function of antioxidant defense proteins and the effects of oxygen derived radicals on protein function is essential to elucidate the...
Resource Type:: Dissertation
Full Text:: approved: ______________________________________________________________ Joseph S. Beckman Oxygen

Measuring protein metal binding via mass spectrometry : copper, zinc superoxide dismutase and amyotrophic lateral sclerosis

Creator:: Rhoads, Timothy W.
Abstract:: Amyotrophic lateral sclerosis (ALS) is a devastating disease characterized by the progressive degeneration of motor neurons. Dominantly-inherited mutations to the antioxidant enzyme Cu,Zn superoxide dismutase (SOD1) cause 3-6% of all ALS cases. The complete mechanism behind the toxicity of mutant SOD1 remains unclear, although significant evidence points to aberrant or...
Resource Type:: Dissertation
Full Text:: : Joseph S. Beckman Amyotrophic lateral sclerosis (ALS) is a devastating disease characterized by

Revealing sequences and modifications of intact proteins using electron fragmentation

Creator:: Franklin, Rachel
Abstract:: People turn to mass spectrometry to answer some of life’s most important questions. From carbon dating of archeological finds to newborn blood screening tests, mass spectrometry allows us to measure molecules which helps advance our knowledge of life and the world we live in. One area of mass spectrometry that...
Resource Type:: Dissertation
Full Text:: . Abstract approved: ______________________________________________________ Joseph S. Beckman

A role for ceramide accumulation in age-related cardiac mitochondrial dysfunction

Creator:: Monette, Jeffrey S.
Abstract:: Ceramides are a group of lipids in the sphingolipid family that are potent cell signaling molecules. Elevations in ceramide levels above the norm generally lead to apoptosis. Evidence from in vitro studies suggests that accumulation of ceramides within mitochondria leads to dysfunction of the mitochondria. This includes inhibition of the...
Resource Type:: Dissertation
Full Text:: like to thank the members of my graduate committee, Drs. Balz Frei, Joseph Beckman, J. Fred Stevens

The effect of hexachlorophene and related compounds on torula yeast glucose-6-phosphate dehydrogenase and some other dehydrogenase enzymes

Creator:: Wang, Jun-Lan
Abstract:: Low concentrations of hexachlorophene (HCP) inhibit a number of pyridine nucleotide-linked dehydrogenase enzymes. The I₅₀ HCP concentrations were 105 μM for pig heart isocitrate dehydrogenase (ICD), 65 μM for horse liver alcohol dehydrogenase, 39 μM for torula yeast glucose-6-phosphate dehydrogenase (G6PD), 6.0 μM for beef heart malate dehydrogenase, and 1.6...
Resource Type:: Dissertation
Full Text:: lipogenesis (Cohn and Joseph, 1959) or, in erythrocytes, for the regeneration of hemoglobin from

The Cathelicidin Anti-microbial peptide gene alters the mouse gut microbiome

Creator:: Rouches, Miles V.
Abstract:: The gut microbiome influences human disease including Type 2 diabetes, obesity and metabolic syndrome and interacts with the innate immune system. The human cathelicidin antimicrobial peptide (hCAMP), an important component of the innate immune system, and vitamin D and xanthohumol, a natural compound found in beer hops, regulate its expression....
Resource Type:: Honors College Thesis
Full Text:: . 12. Christoph A. Thaiss, Niv Zmora, ,Maayan Levy, and Eran ElinavThe microbiome and innate immunity

Conformational Consequences: Calcium Regulates the Association Between Dysferlin C2A & PI(4,5)P2

Creator:: Otto, Shauna C.
Abstract:: Dysferlin is a ∼230 kDa terminally anchored membrane protein that is ubiquitously expressed, but is particularly enriched in skeletal and cardiac muscle tissue. Mutations covering the length of the protein have been linked to muscle wasting diseases including limb-girdle muscular dystrophy and Myoshi myopathy. Dysferlin has been shown to play...
Resource Type:: Dissertation

Characterization of the mechanism and function of C₂H₂ zinc finger protein CTIP2 in the developmental processes

Creator:: Golonzhka, Olga
Abstract:: CTIP2 is a C2H2 zinc finger transcription factor that plays important yet poorly understood roles in mouse development. CTIP2 is known to be highly expressed in the central nervous system, skin and T lymphocytes during embryogenesis. CTIP2-null mice die perinatally of unknown causes and exhibit defects in multiple organ systems...
Resource Type:: Dissertation

ScholarsArchive@OSU

Examining the Human Relevance of a New Mouse Model of ALS and Observations on the Incidence in Human Populations

Oxidative stress in amyotrophic lateral sclerosis : the role of cellular senescence and glutathione

Structural studies of the antioxidant defense enzymes; copper, zinc superoxide dismutase and alkyl hydroperoxide reductase flavoprotein

Measuring protein metal binding via mass spectrometry : copper, zinc superoxide dismutase and amyotrophic lateral sclerosis

Revealing sequences and modifications of intact proteins using electron fragmentation

A role for ceramide accumulation in age-related cardiac mitochondrial dysfunction

The effect of hexachlorophene and related compounds on torula yeast glucose-6-phosphate dehydrogenase and some other dehydrogenase enzymes

The Cathelicidin Anti-microbial peptide gene alters the mouse gut microbiome

Conformational Consequences: Calcium Regulates the Association Between Dysferlin C2A & PI(4,5)P2

Characterization of the mechanism and function of C₂H₂ zinc finger protein CTIP2 in the developmental processes

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