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Filtering by: Committee Member Mason, Barbara J. Remove constraint Committee Member: Mason, Barbara J. Degree Field Biochemistry and Biophysics Remove constraint Degree Field: Biochemistry and Biophysics

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  • Functional and Structural Analyses of Three Distinct proteins by Biochemical and Biophysical Techniques

    Creator:
    Codding, Sara Jone
    Abstract:
    The focus of this dissertation was to understand protein function and structure ona molecular level. To do this successfully, a variety of biochemical and biophysicaltechniques were employed. A wide variety of techniques were applied to study theproteins of interest in this dissertation to probe protein-protein interactions, proteinfunction, protein structure, and...
    Resource Type:
    Dissertation
    Full Text:
    Padmanarayana for our friendly conversations, and Naomi J. Marty, for always reminding me that life is short

  • Protein Disorder in the Evolution of Dynein Regulation

    Creator:
    Jie, Jing
    Abstract:
    Intrinsically disordered proteins (IDP) are a class of proteins that lack a three-dimensional structure and their prevalence and diverse functions in the cell have only been discovered relatively recently. The intermediate chain (IC) subunit of the microtubule motor protein complex dynein contains an N-terminal disordered region, N-IC, which is central...
    Resource Type:
    Dissertation
    Full Text:
    : _____________________________________________________ Elisar J. Barbar Intrinsically disordered proteins (IDP) are a class of proteins that lack

  • Assembly and Regulation of WW-PPXY Complexes in Hippo Signaling

    Creator:
    Baker, Kasie J.
    Abstract:
    The Hippo signaling pathway is an evolutionarily conserved regulator of cell growth, proliferation, and apoptosis. A key function of the pathway is to regulate the subcellular distribution and activity of Yorkie in Drosophila or Yes-associated protein (YAP) and transcription co-activator with PDZ-binding motif (TAZ) in mammals. The dysregulation of the...
    Resource Type:
    Dissertation
    Full Text:
    THE DISSERTATION OF Kasie J. Baker for the degree of Doctor of Philosophy in Biochemistry and

  • Characterization of the Structure and Dynamics of the Intrinsically Disordered Dynein Intermediate Chain and its Interactions with Regulatory Binding Partners

    Creator:
    Morgan, Jessica L.
    Abstract:
    Cells represent microcosms of spatial and temporal structural organization, with the achievement of internal spatial organization relying upon a collection of macromolecular motor complexes to transport and localize components throughout the cell. Cytoplasmic dynein is one such motor complex, and is the principal ATP-dependent motor for retrograde transport along microtubules...
    Resource Type:
    Dissertation
    Full Text:
    Binding Partners. Abstract approved: ______________________________________________________ Elisar J

  • Organization of the T4 dNTP synthetase complex at DNA replication sites

    Creator:
    Kim, JuHyun
    Abstract:
    With respect to a multienzyme complex of deoxyribonucleoside triphosphate (dNTP) synthesis somehow juxtaposed with DNA replication sites, our laboratory has demonstrated the existence of a multienzyme complex in T4-infected E. coli, named the T4 dNTP synthetase complex, but the idea of direct linkage of dNTP synthesis to DNA replication and...
    Resource Type:
    Dissertation
    Full Text:
    to thank my committee members, Drs. Barbara J. Taylor, Walter Ream, Michael M. Schimerlik, and