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Filtering by: Creator Osta, J. Degree Field Biochemistry and Biophysics

A role for ceramide accumulation in age-related cardiac mitochondrial dysfunction

Creator:

Monette, Jeffrey S.

Abstract:

Ceramides are a group of lipids in the sphingolipid family that are potent cell signaling molecules. Elevations in ceramide levels above the norm generally lead to apoptosis. Evidence from in vitro studies suggests that accumulation of ceramides within mitochondria leads to dysfunction of the mitochondria. This includes inhibition of the...

Resource Type:

Dissertation

Full Text:

like to thank the members of my graduate committee, Drs. Balz Frei, Joseph Beckman, J. Fred Stevens
The effect of dietary compounds on human cathelicidin antimicrobial peptide gene expression mediated through farnesoid X receptor and its potential role in gastrointestinal health

Creator:

Campbell, Yan

Abstract:

The human cathelicidin antimicrobial peptide (CAMP) is a broad spectrum microbicidal agent and modulator of both the innate and adaptive immune system. It is induced by 1,25-dihydroxyvitamin D (1,25(OH)₂D₃) through activation of the vitamin D receptor (VDR) and primary bile salts through activation of the xenobiotic nuclear receptor farnesoid X...

Resource Type:

Dissertation