Index Catalog // ScholarsArchive@OSU

Functional and Structural Analyses of Three Distinct proteins by Biochemical and Biophysical Techniques

Creator:: Codding, Sara Jone
Abstract:: The focus of this dissertation was to understand protein function and structure ona molecular level. To do this successfully, a variety of biochemical and biophysicaltechniques were employed. A wide variety of techniques were applied to study theproteins of interest in this dissertation to probe protein-protein interactions, proteinfunction, protein structure, and...
Resource Type:: Dissertation
Full Text:: ! ! ! AN ABSTRACT OF THE DISSERTATION OF Sara Jone Codding for the degree of Doctor of Philosophy in

DNA binding and beyond : an investigation of proteins involved in PAH-induced carcinogesesis

Creator:: Hooven, Louisa Ada
Abstract:: Exposure to polycyclic aromatic hydrocarbons such as benzo[a]pyrene (B[a]P) has been determined to be a risk factor for various forms of human cancer. PAH DNA adducts have been shown to cause mutations, but carcinogenesis is also accompanied by alterations in gene expression. Inhibiting individual cytochrome P450s could clarify the interaction...
Resource Type:: Dissertation
Full Text:: ). SARA and TSA increased EROD activity and in RT-PCR. SARA and TSA reduced B[a]P induced CYP1A1 and

Defining the Role of Tyrosine Nitration in Biology with Genetic Code Expansion

Creator:: Porter, Joseph J.
Abstract:: The buildup of reactive oxygen species (ROS) and reactive nitrogen and oxygen species (RNS) is known as oxidative stress. Oxidative stress results in a wide variety of modification to biological macromolecules including nucleic acids, lipids, and proteins. For at least 30 years it has been known that high levels of...
Resource Type:: Dissertation
Full Text:: THE DISSERTATION OF Joseph J. Porter for the degree of Doctor of Philosophy in Biochemistry and

In vivo Reactions of Tetrazines Incorporated through Genetic Code Expansion

Creator:: Blizzard, Robert J.
Abstract:: The inverse electron demand Diels Alder reaction between tetrazines and strained alkenes is an exceptionally useful tool in functionalizing to biomolecules since it is orthogonal to the chemistry of most living systems and have exceptionally high rate constants. In particular reactions between strained trans-cyclooctenes (sTCO) and tetrazines can achieve second...
Resource Type:: Dissertation
Full Text:: AN ABSTRACT OF THE DISSERTATION OF Robert J

Expression and G protein coupling of the M2 muscarinic acetylcholine receptor in Sf9 insect cells

Creator:: Mosser, Valerie A.
Resource Type:: Dissertation
Full Text:: for teaching me how to be a more thoughtful and rigorous scientist David J. Brodenck, Gary L

Initial in vitro and in vivo Characterization of the Membrane Trafficking Protein Fer1L6

Creator:: Wolk, Chelsea
Abstract:: A fundamental difference between prokaryotic and eukaryotic cells is the presence of membrane bound organelles in eukaryotes. The dynamics of membrane trafficking within the cell are responsible for everything from intercellular communication and cell homeostasis, to mitosis, cell migration, and differentiation. These processes require exocytosis and compensatory endocytosis, often working...
Resource Type:: Dissertation
Full Text:: always steadfast. To the other Johnson lab members, Sara Codding, Dr. Paroma Chatterjee, Dr. Josephine

Endocrine control of proteolysis in cultured muscle cells

Creator:: Hong, Dong-Hyun
Resource Type:: Dissertation
Full Text:: from its cDNA sequence. FEBS Lett. 205:313-317 Ballard, F. J. and G. L. Francis. 1983. Effects of

Conformational Consequences: Calcium Regulates the Association Between Dysferlin C2A & PI(4,5)P2

Creator:: Otto, Shauna C.
Abstract:: Dysferlin is a ∼230 kDa terminally anchored membrane protein that is ubiquitously expressed, but is particularly enriched in skeletal and cardiac muscle tissue. Mutations covering the length of the protein have been linked to muscle wasting diseases including limb-girdle muscular dystrophy and Myoshi myopathy. Dysferlin has been shown to play...
Resource Type:: Dissertation

Purification and characterization of an alkaline phosphatase from Halobacterium salinarium

Creator:: McParland, Reginald Harry
Abstract:: The halophilic alkaline phosphatase of Halobacterium salinarium has been purified to a specific activity of 3,000-3,200 units per mg of protein. The purification scheme consisted of acetone and ammonium sulfate fractionations, and molecular sieving and adsorption chromatography on Sephadex G -50. The enzyme was stabilized during purification by the presence...
Resource Type:: Dissertation
Full Text:: (EDTA), and trichloroacetic acid (TCA) were from J. T. Baker Chemical Company, Phillipsburg, New

Characterizing the Functional Properties of Otoferlin, Essential for Neurotransmission in Inner Hair Cells of the Cochlea

Creator:: Narayanappa, Murugesh
Abstract:: Hearing loss is one of the most common defect, affecting 360 million people worldwide due to several factors including congenital, present at or soon after birth or acquired with age. Congenital hearing loss affects 32 million children in the world. The economic impact of hearing loss is estimated to cost...
Resource Type:: Dissertation
Full Text:: Abdullah, Dr. Naomi Marty, Chelsea Holman, Sara Codding, Paroma Chatterjee, Blake Hakkila, Scott

ScholarsArchive@OSU

Functional and Structural Analyses of Three Distinct proteins by Biochemical and Biophysical Techniques

DNA binding and beyond : an investigation of proteins involved in PAH-induced carcinogesesis

Defining the Role of Tyrosine Nitration in Biology with Genetic Code Expansion

In vivo Reactions of Tetrazines Incorporated through Genetic Code Expansion

Expression and G protein coupling of the M2 muscarinic acetylcholine receptor in Sf9 insect cells

Initial in vitro and in vivo Characterization of the Membrane Trafficking Protein Fer1L6

Endocrine control of proteolysis in cultured muscle cells

Conformational Consequences: Calcium Regulates the Association Between Dysferlin C2A & PI(4,5)P2

Purification and characterization of an alkaline phosphatase from Halobacterium salinarium

Characterizing the Functional Properties of Otoferlin, Essential for Neurotransmission in Inner Hair Cells of the Cochlea

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