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The oxidative demethylation of certain N-methylhydrazines by microsomal liver enzymes

Creator:: Wittkop, Judith Anne
Abstract:: The presence in rat liver microsomes of an enzyme system which demethylates N-methylhydrazines and azo compounds to formaldehyde has been reported. Some of the compounds found to be substrates were monomethylhydrazine, N-isopropyl-α-(2-methylhydrazino)- p-toluamide and the azo derivative of the latter hydrazine. This enzyme can be classified as a mixed function...
Resource Type:: Dissertation
Full Text:: . Phenobarbital also has been found by Rubin (1964) to cause an increase in the Vmax but not the K values of

Characterization of different forms of lysophospholipase in barley

Creator:: Lundgard, Robert
Abstract:: During barley germination, α-amylase and other hydrolases are synthesized in the aleurone layer and secreted into the starchy endosperm. As starch is degraded by amylases, lysophospholipids are released from inclusion complexes with the starch and undergo hydrolysis by a lysophospholipase (LPL) activity. Studies with embryo-free half seeds and isolated aleurone...
Resource Type:: Dissertation

DNA binding and beyond : an investigation of proteins involved in PAH-induced carcinogesesis

Creator:: Hooven, Louisa Ada
Abstract:: Exposure to polycyclic aromatic hydrocarbons such as benzo[a]pyrene (B[a]P) has been determined to be a risk factor for various forms of human cancer. PAH DNA adducts have been shown to cause mutations, but carcinogenesis is also accompanied by alterations in gene expression. Inhibiting individual cytochrome P450s could clarify the interaction...
Resource Type:: Dissertation

Novel icosanoids from the red marine alga Farlowia mollis

Creator:: Solem, Michele Lee
Abstract:: Farlowia mollis is a marine red alga that grows in the intertidal region along the coast of Oregon. We began studying the chemistry of this alga after a survey of Oregon seaweeds revealed possibly interesting chemistry and antimicrobial activity in its crude organic extract. Over the past three years the...
Resource Type:: Masters Thesis

Cytoskeletal regulation in cell motility and invasion

Creator:: Jang, Hyo Sang
Abstract:: Cell motility and invasion are important for development, immunity, wound healing, and tumor cell metastasis. Cells on two dimensional substrates migrate in three steps: protrusion of the front end, translocation of the cell body, and retraction of the rear end. For cells to migrate efficiently, these steps need to be...
Resource Type:: Dissertation

Cyclic nucleotides, cyclic nucleotide phosphodiesterase, protein kinase, and phosphoprotein phosphatase in the central nervous system of Manduca sexta

Creator:: Albin, Edward Elmo
Abstract:: Adenosine 3', 5' -cyclic monophosphate (cyclic AMP, cAMP) and guanosine 3', 5' -cyclic monophosphate (cyclic GMP, cGMP) were quantitated in the central nervous system (CNS) of the insect Manduca sexta by competitive protein binding techniques. The M. sexta CNS was found to contain a strikingly high level of cGMP, about...
Resource Type:: Dissertation

Characterization of photochemically cross-linked protein-nucleic acid complexes by mass spectrometry

Creator:: Jensen, Ole Norregaard
Abstract:: A novel protocol for the study of protein-nucleic acid interactions is presented and demonstrated to be feasible. The protocol combines photochemical crosslinking techniques and mass spectrometric methods into a new strategy for identifying protein domains or amino acid residues that are in close contact with nucleic acid in protein-nucleic acid...
Resource Type:: Dissertation

Specificity, Allostery, and Multivalency in Binding to the Hub Protein LC8

Creator:: Estelle, Aidan B.
Abstract:: Interactions between proteins are essential to life, driving and regulating a majority of processes within all living cells. Study of protein-protein interactions reveals that some proteins act as hubs within networks of interactions, binding to many partner proteins. These hubs therefore are of particular importance to understanding protein function, interwoven...
Resource Type:: Dissertation

Towards Resolving Functional and Evolutionary Mysteries of the Large and Heterozygous Genome of Hop (Humulus lupulus) and the Cannabaceae Family Using Genomic Data Science

Creator:: Padgitt-Cobb, Lillian K.
Abstract:: Hop (Humulus lupulus L. var. lupulus) is a diploid, dioecious plant with an extensive history of cultivation and use in brewing, as a textile, and for its therapeutic properties. Hop is prized for its ability to produce a variety of aromatic and flavor compounds, as well as compounds with anti-microbial...
Resource Type:: Dissertation

ScholarsArchive@OSU

The oxidative demethylation of certain N-methylhydrazines by microsomal liver enzymes

Characterization of different forms of lysophospholipase in barley

DNA binding and beyond : an investigation of proteins involved in PAH-induced carcinogesesis

Novel icosanoids from the red marine alga Farlowia mollis

Cytoskeletal regulation in cell motility and invasion

Cyclic nucleotides, cyclic nucleotide phosphodiesterase, protein kinase, and phosphoprotein phosphatase in the central nervous system of Manduca sexta

Characterization of photochemically cross-linked protein-nucleic acid complexes by mass spectrometry

Specificity, Allostery, and Multivalency in Binding to the Hub Protein LC8

Towards Resolving Functional and Evolutionary Mysteries of the Large and Heterozygous Genome of Hop (Humulus lupulus) and the Cannabaceae Family Using Genomic Data Science

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