Index Catalog // ScholarsArchive@OSU

Revealing sequences and modifications of intact proteins using electron fragmentation

Creator:: Franklin, Rachel
Abstract:: People turn to mass spectrometry to answer some of life’s most important questions. From carbon dating of archeological finds to newborn blood screening tests, mass spectrometry allows us to measure molecules which helps advance our knowledge of life and the world we live in. One area of mass spectrometry that...
Resource Type:: Dissertation

An Evaluation of Community Attitudes Towards Gender-Based Violence in Partnership with the Community of Maunatlala, Botswana

Creator:: Petrina, Grace E.
Abstract:: Gender-based violence (GBV) is a pervasive public health issue that continues to affect women globally. GBV is estimated to impact 37% of Botswanan women, exceeding the average global prevalence of 30%. This investigation takes place within the Botswana Global Health Initiative, a collaboration led by OSU researchers, the community of...
Resource Type:: Honors College Thesis

The analysis of kisspeptin neuronal exosomes and their effects on neuronal plasticity of downstream gonadotropin-releasing hormone expressing neurons

Creator:: Ewton, Jessica
Abstract:: Gonadotropin-releasing hormone (GnRH) neurons are able to trigger the release of luteinizing hormone and follicle-stimulating hormone which control the maturation of oocytes and ovulation which is vital for reproduction. They are the most downstream neurons that project to the median eminence into the pituitary portal where they release GnRH. Modulation...
Resource Type:: Honors College Thesis

Specificity, Allostery, and Multivalency in Binding to the Hub Protein LC8

Creator:: Estelle, Aidan B.
Abstract:: Interactions between proteins are essential to life, driving and regulating a majority of processes within all living cells. Study of protein-protein interactions reveals that some proteins act as hubs within networks of interactions, binding to many partner proteins. These hubs therefore are of particular importance to understanding protein function, interwoven...
Resource Type:: Dissertation

Strength in Numbers: How Multivalent WW-PPXY Interactions Regulate Cell Signaling

Creator:: Vogel, Amber J.
Abstract:: Cell signaling is often mediated by protein-protein interactions, which must be specific, tunable, and transient to allow agile responsiveness to cellular messages. Due to their unique properties, multivalent, intrinsically disordered proteins make ideal candidates to accomplish these vital tasks. A single protein with multiple binding sites may bind numerous partners,...
Resource Type:: Dissertation

The Role of Cellular Senescence in the Development of Alzheimer's Disease

Creator:: Riordan, Ruben
Abstract:: Alzheimer’s Disease (AD) is a neurodegenerative pathology currently affecting nearly 44 million individuals worldwide, yet there are not currently any effective treatments or preventions for AD despite the rapid development in our understanding of the disease over the last four decades. The medical and sanitary innovations of the last century...
Resource Type:: Dissertation

Towards Resolving Functional and Evolutionary Mysteries of the Large and Heterozygous Genome of Hop (Humulus lupulus) and the Cannabaceae Family Using Genomic Data Science

Creator:: Padgitt-Cobb, Lillian K.
Abstract:: Hop (Humulus lupulus L. var. lupulus) is a diploid, dioecious plant with an extensive history of cultivation and use in brewing, as a textile, and for its therapeutic properties. Hop is prized for its ability to produce a variety of aromatic and flavor compounds, as well as compounds with anti-microbial...
Resource Type:: Dissertation

Understanding Circadian and Light-activated Transcriptional Regulatory Changes During Aging in Drosophila melanogaster

Creator:: Fey, Rosalyn M.
Abstract:: Systems biology is a powerful approach which considers and sheds light on all of the puzzle pieces which make up complex biological processes, and is an effective alternative to unraveling these processes using traditional molecular approaches alone. It is a natural companion approach for computational biology, which leverages the power...
Resource Type:: Dissertation

Context matters : assembly and disorder in the regulation of multivalent complexes

Creator:: Jara, Kayla A.
Abstract:: Intrinsically disordered proteins (IDPs), protein regions (IDRs), and protein complexes continue to emerge at the forefront of protein science. Proteins and protein regions lacking specific structure are found in all organisms, and often have vital roles in numerous biological processes. Breaking the well-known structure-function paradigm, the understanding of disorder-based functionality...
Resource Type:: Dissertation

Characterization and Functionalization of Fabric for use in an Immunoassay

Creator:: White, Natalie
Abstract:: Paper-based microfluidic assays, like the common pregnancy test, allow for rapid screening at the point- of-care at low cost and with no instrumentation. Fabric has many similar properties to paper, but is more flexible and durable, making it a promising option for use in a variety of diagnostic and screening...
Resource Type:: Honors College Thesis

ScholarsArchive@OSU

Revealing sequences and modifications of intact proteins using electron fragmentation

An Evaluation of Community Attitudes Towards Gender-Based Violence in Partnership with the Community of Maunatlala, Botswana

The analysis of kisspeptin neuronal exosomes and their effects on neuronal plasticity of downstream gonadotropin-releasing hormone expressing neurons

Specificity, Allostery, and Multivalency in Binding to the Hub Protein LC8

Strength in Numbers: How Multivalent WW-PPXY Interactions Regulate Cell Signaling

The Role of Cellular Senescence in the Development of Alzheimer's Disease

Towards Resolving Functional and Evolutionary Mysteries of the Large and Heterozygous Genome of Hop (Humulus lupulus) and the Cannabaceae Family Using Genomic Data Science

Understanding Circadian and Light-activated Transcriptional Regulatory Changes During Aging in Drosophila melanogaster

Context matters : assembly and disorder in the regulation of multivalent complexes

Characterization and Functionalization of Fabric for use in an Immunoassay

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