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  • Activation and Nuclear Translocation of the Transcription Factor Nrf2 by the MAP Kinase Family

    Creator:
    Nguyen, Ngan H.
    Abstract:
    Eukaryotic cells have developed elaborate biochemical processes to counteract oxidative stress, electrophiles, or carcinogens due to environmental insults. One of these important cellular defense mechanisms is mediated by the transcription factor Nrf2 that have been shown to have decrease activity with age. While the process of which Nrf2 is involved...
    Resource Type:
    Honors College Thesis
    Full Text:
    of Graphs Graph Page 1. Testing effect of APAP and Menadione on Nrf2 nuclear localization…. 10

  • Structural and activity characterization of irradiated antimicrobial peptide (WLBU2) for use in blood processing and biomedical applications

    Creator:
    Cheung, Daniel Y. C.
    Abstract:
    Sepsis is a life-threatening blood infection which leads to an uncontrolled systemic inflammatory state. In North America alone, sepsis annually afflicts approximately 750,000 individuals and kills 38-50% of these (more than HIV/AIDS, breast cancer, and colon cancer combined). Current treatment involves administration of IV fluids, antibiotics and hemoperfusion, requiring prolonged...
    Resource Type:
    Honors College Thesis
    Full Text:
    AN ABSTRACT OF THE THESIS OF Daniel Y.C. Cheung for

  • Characterization and application of PEO-containing triblock copolymer surfactants

    Creator:
    Snider, Joshua L.
    Abstract:
    The action of pendant, polyethylene oxide (PEO) brush layers as nonfouling coatings for biomedical materials is well understood. However progress toward clinical application of stable, high density PEO coatings has historically been impeded by the lack of cost effective, noninvasive methods for their preparation. Triblock polymers featuring a hydrophobic, polypropylene...
    Resource Type:
    Honors College Thesis
    Full Text:
    evaluation of PEO-coated materials for microchannel hemodialyzer. Journal of Biomedical Materials Research

  • Demonstration of an Alginate Valve in a Paper Microfluidic Device

    Creator:
    Cornwell, David Q.
    Abstract:
    Paper microfluidic devices are capable of processing fluids using capillary flow in materials that are lower cost than the standard materials used in microfluidics. Due to the low cost of their fabrication and minimal requirements for instrumentation, paper microfluidic devices are ideal for use in low-resource settings. They have the...
    Resource Type:
    Honors College Thesis
    Full Text:
    are capable of processing fluids using capillary flow in materials that are lower cost than the

  • Development and Optimization of Medicinal Infused Hydrogel Patch and Cloth for the Treatment of Burn Patients

    Creator:
    Carpenter, Molly E.
    Abstract:
    Rapid and effective treatment of burn injuries is critical to prevent long term damage. Besides the pain associated with the burn injury due to damage and death of surrounding tissue and cells, there is a large risk for complications, particularly infection, following a burn injury. To address these risks, Meta...
    Resource Type:
    Honors College Thesis
    Full Text:
    Material Systems, Inc developed Metamix, a proprietary mixture of botanical compounds with assumed

  • The Effect of an Ethics Course on Bioengineering Students' Understanding of Social Justice Issues in the Context of Engineering

    Creator:
    Rinker, Torri E.
    Abstract:
    The nature of engineering work requires that ethical considerations are taken into account while making decisions surrounding topics such as technology, equal distribution of cost benefits, and consumer risk. In order for engineers to make ethical decisions in their careers, it is helpful if their engineering education provided them with...
    Resource Type:
    Honors College Thesis
    Full Text:
    understanding of ethics in an engineering career. For those impacted by the material presented in this course

  • The Bioethics of Implantable Engineered Mechanisms in Orthopedic Surgery

    Creator:
    Chatterjee, Sarani
    Abstract:
    The ethics of implant technology is a wide-ranging topic in the field of bioethics. This paper intends to add to the ethical discourse of implant technology by addressing a new class of implants applicable to orthopedic surgery. These new implants are engineered mechanisms that attach muscles to tendons and bones...
    Resource Type:
    Honors College Thesis
    Full Text:
    dependent on the material and the careful implantation of the artificial joints. Massive polyethylene

  • Enhanced Delivery of Cryoprotectant Chemicals to Cultured Neurons

    Creator:
    Wilson, Jenna L.
    Abstract:
    Due to the many advances in the areas of biotechnology and medicine, the need for long- term storage and stabilization of biological materials is rapidly increasing. The field of biopreservation is attempting to address these issues by finding ways to maintain the integrity and functionality of proteins, cells, and organs...
    Resource Type:
    Honors College Thesis
    Full Text:
    , the need for long- term storage and stabilization of biological materials is rapidly increasing. The

  • The Role of Syndecan-1 in Arterial Mechanotransduction

    Creator:
    Steyer, Benjamin G.
    Abstract:
    Hemodynamic forces regulate vascular homeostasis and arterial structure through mechanical stimuli by a process called mechanotransduction. Cellular response to mechanical forces involves coordination between cell surface receptors and intracellular signaling pathways. While previous work has focused on the role of integrin receptors in mechanotransduction, little is known about the role...
    Resource Type:
    Honors College Thesis
    Full Text:
    pathways…………4 Effects of mechanical stretch on VSMCs…………………………………………6 MATERIALS AND METHODS

  • The Role of Syndecan-1 in Arterial Mechanotransduction.

    Creator:
    Steyer, Benjamin G.
    Abstract:
    Hemodynamic forces regulate vascular homeostasis and arterial structure through mechanical stimuli by a process called mechanotransduction. Cellular response to mechanical forces involves coordination between cell surface receptors and intracellular signaling pathways. While previous work has focused on the role of integrin receptors in mechanotransduction, little is known about the role...
    Resource Type:
    Honors College Thesis
    Full Text:
    pathways…………4 Effects of mechanical stretch on VSMCs…………………………………………6 MATERIALS AND METHODS