Index Catalog // ScholarsArchive@OSU

Mathematically modeling transient temperature variation in a human neonate undergoing intensive blue light phototherapy for management of hyperbilirubinemia

Creator:: Gondhalekar, Vikram B.
Abstract:: Neonatal jaundice secondary to hyperbilirubinemia occurs in 60% of all term newborns and nearly all preterm newborns in the US. Severe cases of this may lead to chronic encephalopathy, neurologic deficits, and, in some cases, death. Intensive blue light phototherapy involves irradiation of a patient with high intensity light and...
Resource Type:: Honors College Thesis
Full Text:: :_____________________________________________________ Adam Higgins Neonatal jaundice secondary to hyperbilirubinemia occurs in 60% of all

Enhanced Delivery of Cryoprotectant Chemicals to Cultured Neurons

Creator:: Wilson, Jenna L.
Abstract:: Due to the many advances in the areas of biotechnology and medicine, the need for long- term storage and stabilization of biological materials is rapidly increasing. The field of biopreservation is attempting to address these issues by finding ways to maintain the integrity and functionality of proteins, cells, and organs...
Resource Type:: Honors College Thesis
Full Text:: : _________________________________________________________ Adam Higgins Due to the many advances in the areas of biotechnology and medicine

Role of P2Y₁₂ Inhibition in PAR1 Stimulated Platelet Dense Granule Release

Creator:: Laschober, Nicole B.
Abstract:: Platelet activation uses a complex set of pathways to respond to vascular injury during hemostasis. However, thrombosis relies on the same set of pathways. Antiplatelet therapies used to prevent thrombotic events often target the P2Y₁₂ platelet receptor for inhibition but can result in bleeding diathesis or in abnormally high ADP...
Resource Type:: Honors College Thesis
Full Text:: University _____________________________________________________________________ Adam Higgins

Experimental and Mathematical Approaches for Overcoming Mass and Heat Transfer Limitations in Cryopreservation of Vertebral Bodies

Creator:: Forcier, Ryan J.
Abstract:: Successful cryopreservation of bone marrow in situ within vertebral bodies offers an opportunity for quick and convenient storage of a significant quantity of bone marrow stem cells, including hematopoietic- and mesenchymal-type stem cells. However, cryopreservation of more complex large tissues and organs, such as the vertebral body (VB), remains problematic....
Resource Type:: Masters Thesis
Full Text:: : ______________________________________________________ Adam Z. Higgins Successful cryopreservation of bone marrow in situ within vertebral

Novel Predictive Simulation of Organ Perfusion Kinetics for Design of Cryopreservation Procedures

Creator:: Johnson, Hill S.
Abstract:: Despite the many advances in biotechnology and biomedical engineering, the need for long term organ and tissue storage remains among the unsolved problems in the field. Researchers are investigating several possible solutions to the issue that aim to maintain the function and integrity of the biological tissues during storage and...
Resource Type:: Honors College Thesis
Full Text:: : ___________________________________________________ Adam Higgins Despite the many advances in biotechnology and biomedical engineering, the

Investigating the Potential for Cryopreservation of Human Granulocytes with Concentrated Glycerol

Creator:: Moss, Alden C.
Abstract:: Granulocytes are a class of white blood cells essential to immune function. Granulocyte transfusions hold promise to treat many conditions, but the short-shelf life of granulocytes makes transfusions infeasible without a cell preservation method. The purpose of this study was to investigate the potential for cryopreservation of granulocytes using 30%...
Resource Type:: Honors College Thesis
Full Text:: :_____________________________________________________ Adam Higgins Granulocytes are a class of white blood cells essential to immune function

Development of Rapid Diagnostic Tools for Personal Health Monitors in the Context of Therapy Monitoring

Creator:: Wentland, Lael T.
Abstract:: Personal health monitoring tools, a subset of point-of care-diagnostics, enable more frequent testing of chronic health conditions outside of a clinic setting and can inform personalized therapy or support telehealth diagnostic capabilities. While there is evidence that regular monitoring of chronic conditions can lead to better health outcomes and lower...
Resource Type:: Dissertation
Full Text:: AN ABSTRACT OF THE DISSERTATION OF Lael T

Precision Medicine for the Intervertebral Disc: Image Processing and Computational Modeling of Disc Degeneration to Inform Patient-Specific Therapies

Creator:: Ahrens, Sonia R.
Abstract:: The human intervertebral disc is a deceptively simple structure which plays an essential role in human movement. Even slight changes to the disc microenvironment can have far reaching consequences, particularly when these changes result in disc degeneration and herniation. Degeneration is increasingly tied to lower back pain; better understanding this...
Resource Type:: Masters Thesis
Full Text:: left empty. Intervention P ai n Fu n ct io n P at ie n t Sa ti sf ac ti o n

Investigation of the effects of cryopreservation on cellular viability and mechanical integrity of the intervertebral disc

Creator:: Forcier, Ryan J.
Abstract:: Degeneration of the intervertebral disc (IVD) is a phenomenon that has yet to be adequately addressed. Treatment options remain limited and incomplete. The ability to effectively cryopreserve IVDs would allow for better allograft transplantations and storage of samples for research purposes. This study aimed to assess how cryopreservation with different...
Resource Type:: Honors College Thesis
Full Text:: _____________________________________________________________________ Adam Higgins, Committee Member, representing Bioengineering

Bioactive and Biocompatible Coatings for Endotoxin Capture in Treatment of Sepsis

Creator:: Su, Jonathan
Abstract:: Sepsis is a blood infection caused by circulating pathogens and cell wall fragments that affects over 1 million patients per year in the United States. When bacterial cell membranes are lysed by antibiotics, cell wall fragments containing lipopolysaccharides (LPS) are released. As a result, the capture of LPS is critical...
Resource Type:: Honors College Thesis
Full Text:: _____________________________________________________________________ Adam Higgins, Committee Member, representing Chemical, Biological, and Environmental Engineering

ScholarsArchive@OSU

Mathematically modeling transient temperature variation in a human neonate undergoing intensive blue light phototherapy for management of hyperbilirubinemia

Enhanced Delivery of Cryoprotectant Chemicals to Cultured Neurons

Role of P2Y₁₂ Inhibition in PAR1 Stimulated Platelet Dense Granule Release

Experimental and Mathematical Approaches for Overcoming Mass and Heat Transfer Limitations in Cryopreservation of Vertebral Bodies

Novel Predictive Simulation of Organ Perfusion Kinetics for Design of Cryopreservation Procedures

Investigating the Potential for Cryopreservation of Human Granulocytes with Concentrated Glycerol

Development of Rapid Diagnostic Tools for Personal Health Monitors in the Context of Therapy Monitoring

Precision Medicine for the Intervertebral Disc: Image Processing and Computational Modeling of Disc Degeneration to Inform Patient-Specific Therapies

Investigation of the effects of cryopreservation on cellular viability and mechanical integrity of the intervertebral disc

Bioactive and Biocompatible Coatings for Endotoxin Capture in Treatment of Sepsis

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