Index Catalog // ScholarsArchive@OSU

Creator:: Kuiper, Damien L.
Abstract:: Azaspiracid has generated an enormous amount of scientific interest in the fourteen years since its initial discovery. The structure contains a 6,5,6 bis-spiroketal, a [3.3.1] bicyclic ketal and a 6,5-spiroaminal linkage as key moieties. With 9 rings, 20 stereocenters and three alkenes, the azaspiracid immediately attracted the interest of the...
Resource Type:: Dissertation
Full Text:: Heteroatom Michael Approach to the FGHI ring sysem….…………...……………. 11 1.9: Nicolaou!s Approach to the FGHI

Creator:: Li, Jinming
Abstract:: Mandelalide A has attracted considerable interest from the synthetic community due to its intriguing structure and important cytotoxic activity. Madeirolide A, a structurally related macrolide, shows promising antifungal activity but no appreciable anticancer activity. This dissertation describes synthetic studies toward mandelalide A, madeirolide A and their hybrid structures. Part I...
Resource Type:: Dissertation
Full Text:: 1.3.2 may arise from hetero-Michael cyclization of thioester 1.3.3 to build the 2,6-cis

Creator:: Schiedler, David A.
Abstract:: Organic compounds which contain one or more nitrogen atoms are especially important as they are disproportionately represented among biologically active molecules. As a result, significant effort has been focused on the development of methods for the synthesis of nitrogenous molecules. We identified the aminal as an under-explored functional group. Despite...
Resource Type:: Dissertation

Creator:: Smits, Helmars
Abstract:: Studies towards the total synthesis of (−)-kendomycin (1), a bacterial metabolite with a unique molecular architecture and pronounced biological activity, are described. These studies resulted in the synthesis of advanced intermediate 208, containing all of the carbon atoms of 1. A Dötz annulation between alkyne 122 and novel chromium carbenoid...
Resource Type:: Dissertation
Full Text:: the free diol underwent an intramolecular Michael addition to furnish tetrahydropyran 44 with high

Creator:: Wang, Shan
Resource Type:: Dissertation
Full Text:: - dioxaspiro[5.5]undecanes 19 374. Michael addition to oxazolidinone 14 5. Transition state for (Z

Creator:: Shanmugham, Meenakshi Sundaram
Abstract:: Two approaches to the tricyclic core of the furanoeremophilane sesquiterpenoids are described. The first approach entails a projected Diels-Alder/retro Diels-Alder reaction of an acetylenic oxazole 64. Construction of the pivotal aldehyde 67 commenced from ketone 68. The acetyenic moiety was then introduced via a Felkin-Ahn addition of lithiopropyne to aldehyde...
Resource Type:: Dissertation
Full Text:: - dione 51. Michael addition of 51 to (Z)-1-nitro-1-thiophenylpropene, followed by condensation, with

Creator:: Vasquez de Montalvo, Socorro I.
Abstract:: This thesis is concerned with the development and use of routine analysis techniques based on chemiluminescence (CL) detection for: 1) ethanol in gin down to the 0.3% (v/v) level; 2) the antioxidants propyl gallate and BHA in lard to levels as low as 0.3 and 0.2 mg/L, respectively; 3) pyrogallol...
Resource Type:: Dissertation

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