Index Catalog // ScholarsArchive@OSU

Synthesis and chacteristics of new solid-state borates

Creator:: Thompson, Paul Douglas
Resource Type:: Dissertation
Full Text:: ABSTRACT OF THE THESIS OF Paul D. Thompson for the degree of Doctor of Philosophy in Chemistry presented

Gene Expression, Structure Elucidation, and Bioactivity of Aspergillus Natural Products

Creator:: Neuhaus, George F.
Abstract:: The study of natural products (NPs) and their application has shaped humanity. Starting with the idea of using plants as medicine, it has now grown into the science of purifying and identifying organic molecules from nature to study their inherent biological activities. Understanding the molecular structures of NPs is the...
Resource Type:: Dissertation
Full Text:: in Chemistry presented on May 28, 2020. Title: Gene Expression, Structure Elucidation, and

Dihalocarbene reactions with steroid olefins

Creator:: Cornelia, Richard Hartman
Abstract:: Dihalocarbenes have been generated mainly by thermal decomposition of sodium trihaloacetate and phenyl (trihalomethyl)mercury, and give gem-dihalocyclopropyl adducts with various steroid olefins. A new procedure involving the use of sealed tubes makes possible the addition of dihalocarbenes to sterically hindered olefins. In this manner, 7-cholestenyl benzoate when treated with PhHgCC1₃...
Resource Type:: Dissertation
Full Text:: . Thomas Bond for his critical reading of the manuscript. TABLE OF CONTENTS INTRODUCTION 1

Synthetic, structural, and spectroscopic investigations of acentric laser hosts and ionic optical converters

Creator:: Reynolds, Thomas A. (Thomas Allen), 1959-
Resource Type:: Dissertation
Full Text:: Acentric, Laser Hosts and Ionic Opticals Converters AN ABSTRACT OF THE THESIS OF Thomas A. Reynolds for

Total synthesis of (+)-bourgeanic acid and conformational analysis of its dilactone

Creator:: Johnson, Alan T. (Alan Thomas), 1957-
Resource Type:: Dissertation

CoLocalized Excitation Emission Resolution : A CLEER approach for multicolor fluorescence analysis

Creator:: Almlie, C. Kyle
Abstract:: Fluorescence has proven to be a robust and powerful method of analysis in numerous fields: forensics, pharmaceutics, geology, food science, and environmental sciences have all developed a large collection of fluorescence instruments and methods to overcome application-specific challenges. Biological applications saw the same development of a fluorescence toolkit with methods...
Resource Type:: Dissertation
Full Text:: playing an important role in post-transcriptional gene regulation. Since then, miRNA have closely

Innovative Bioanalytical Tools & Methods for Combinatorial Non-Coding RNA Analysis

Creator:: Zhang, Lulu
Abstract:: Recently researchers have discovered that groups of small non-coding RNAs (ncRNAs) play regulatory roles in gene expression and participate in various biological processes. For example, pathogenesis of many diseases, cell cycle regulation, and signaling pathways. Intracellular and live cell imaging of small ncRNA groups will reveal their relative expression levels...
Resource Type:: Dissertation
Full Text:: (ncRNAs) play regulatory roles in gene expression and participate in various biological processes.1–4

Pactamycin Inspired Drug Discovery: A Synthetic and Chemoenzymatic Approach

Creator:: Brumsted, Corey J.
Abstract:: Pactamycin, first reported in 1962, is a potent antitumor antibiotic produced by the soil bacterium Streptomyces pactum. Structurally, it contains a cyclopentitol core unit, a 3-aminoacetophenone (3AAP), a 6-methylsalicylic acid (6-MSA), and a N,N-dimethyl urea. The aminocyclopentitol ring is derived from glucose, possibly via N-acetyl glucosamine (GlcNAc), the 3-aminoacetophenone (3AAP)...
Resource Type:: Dissertation
Full Text:: subsequently undergoes non-enzymatic decarboxylation. In addition to the β-ketoacyl-ACP synthase gene ptmK

Drug Discovery from Diverse Bacteria – Bioactivity-guided Isolation of Known and New Metabolites

Creator:: Zhu, Chenxi
Abstract:: Exploring bioactive natural products has contributed largely to clinically approved drugs we have been using over the last 100 years. Especially among the anti-infective drugs, around 70% of currently used antibiotics were discovered or derived from microbial secondary metabolites, among them compounds like vancomycin, chloramphenicol, and erythromycin. Facing the unavoidable...
Resource Type:: Dissertation
Full Text:: 16S rRNA gene sequence amplification, generated with MEGA7 [10]. The evolutionary history was

Effects of small molecule ligands on the conformational dynamics of the Farnesoid X Receptor ligand binding domain (FXR-LBD)

Creator:: Yang, Liping
Abstract:: The Farnesoid X Receptor (FXR) is a member of the nuclear receptor superfamily of transcription factors that plays a key role in the regulation of bile acids, lipid and glucose metabolisms. The regulative function of FXR is governed by conformational changes of the ligand binding domain (LBD) upon ligand binding....
Resource Type:: Dissertation
Full Text:: determination of hepatic gene expression in XN-fed mice suggested that XN acts as an selective bile acid

ScholarsArchive@OSU

Synthesis and chacteristics of new solid-state borates

Gene Expression, Structure Elucidation, and Bioactivity of Aspergillus Natural Products

Dihalocarbene reactions with steroid olefins

Synthetic, structural, and spectroscopic investigations of acentric laser hosts and ionic optical converters

Total synthesis of (+)-bourgeanic acid and conformational analysis of its dilactone

CoLocalized Excitation Emission Resolution : A CLEER approach for multicolor fluorescence analysis

Innovative Bioanalytical Tools & Methods for Combinatorial Non-Coding RNA Analysis

Pactamycin Inspired Drug Discovery: A Synthetic and Chemoenzymatic Approach

Drug Discovery from Diverse Bacteria – Bioactivity-guided Isolation of Known and New Metabolites

Effects of small molecule ligands on the conformational dynamics of the Farnesoid X Receptor ligand binding domain (FXR-LBD)

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