Index Catalog // ScholarsArchive@OSU

Start Over

Filtering by: Creator Yan, Kai-tuan Kelvin Degree Field Chemistry Degree Level Master's

Towards the Perfect Marriage Between Theory and Experiments in Drug Discovery and Synthesis : Insights into Structure Determination of Complex Natural Products and Mechanistic Understandings of Lactam Synthesis

Creator:

Snyder, Kevin M.

Abstract:

In this report, three studies are presented that aid in the development of drug discovery and their synthesis. In each, the importance of the marriage between computations and experiments is highlighted. Continued efforts in this vein are essential for future efforts towards improving human health. The first case study investigated...

Resource Type:

Masters Thesis

Full Text:

over ten picoseconds (ps) from 0 to 300 Kelvin under constant volume and periodic-boundary conditions
Mass spectrometric analysis of bovine neurofilament proteins NF-L, NF-M, and NF-H : peptide mapping, phosphorylation and alkylation site identification

Creator:

Mixon, April E.

Abstract:

Neurofilament proteins are intermediate filaments found in the neuronal cytoskeleton. Phosphorylation of these proteins is considered important for the assembly and stability of the filaments. Accurate molecular weights have been difficult to measure, largely because the high degree of phosphorylation results in M[subscript r]'S that are significantly greater than dictated...

Resource Type:

Masters Thesis

Full Text:

and Kelvin Mixon. And to my friends, Phil Gafken, Rhonda Kaetzel, Andrew Bauman, Rob Kovacich