Index Catalog // ScholarsArchive@OSU

Total synthesis of phorboxazole A

Creator:: Lee, Tae Hee
Abstract:: The total synthesis of a highly potent cytotoxic marine natural product, phorboxazole A, is described. Both a palladium(II)-mediated and a palladium(II)-catalyzed intramolecular alkoxycarbonylation were used as key steps for the preparation of the two cis-2,6-disubstituted tetrahydropyran rings (C22-C26 and C11-C15) of phorboxazole A. The synthesis used a convergent approach involving...
Resource Type:: Dissertation
Full Text:: ABSTRACT OF THE DISSERTATION OF Tae Hee Lee for the degree of Doctor of Philosophy in Chemistry

Studies towards the total synthesis of (-)-kendomycin

Creator:: Smits, Helmars
Abstract:: Studies towards the total synthesis of (−)-kendomycin (1), a bacterial metabolite with a unique molecular architecture and pronounced biological activity, are described. These studies resulted in the synthesis of advanced intermediate 208, containing all of the carbon atoms of 1. A Dötz annulation between alkyne 122 and novel chromium carbenoid...
Resource Type:: Dissertation
Full Text:: The first total synthesis of 1 was reported by Lee and co-workers in late 2004.4 Their synthetic

Gas-phase fragmentation chemistry of protonated peptide ions

Creator:: Bythell, Benjamin James
Abstract:: The fragmentation characteristics of protonated peptides have been investigated using tandem mass spectrometry (MS/MS) under various fragmentation regimes and detailed density functional theory (DFT) reaction pathway calculations. The DFT calculations predict novel salt-bridge stabilized transition structures as well as consecutive reactions occurring in proton-bound dimers for some of the ions...
Resource Type:: Dissertation

Polarization spectroscopy and photodissociation studies of nitroaromatic compounds in the gas phase

Creator:: Abbott, James E.
Abstract:: The central purpose of this dissertation was to explore and expand the use of an uniform electric field for orientation and for subsequent spectroscopic investigation of asymmetric polar molecules in the gas phase. The systems of study were nitrobenzene (NB) and the nitrotoluene (NT) isomers. We were able to quantitatively...
Resource Type:: Dissertation

Synthesis and characterization of novel stationary phases for small scale liquid chromatographic separations of proteins and nanoparticles

Creator:: Hutanu, Daniela
Abstract:: The emerging field of nanotechnology strictly requires the micro-scaling of the available separation technology and the design of novel devices for separations of molecules of interest. The separation of proteins and nanoparticles is challenging due to their relatively large size, non-specific adherence to surfaces and instability in many solvents. This...
Resource Type:: Dissertation

Luminescent sulfides and solution-deposited oxide thin films

Creator:: Anderson, Jeremy T.
Abstract:: Solid state luminescent sulfides are prepared as powders in order to elucidate the relationship between structure and light emission. While the sulfides studied in this dissertation are known phosphors, materials are investigated in a variety of new ways. Elementary properties and structures of MgS are reviewed, and preparation of MgS...
Resource Type:: Dissertation

Studies toward the synthesis of halichlorine and pinnaic acid

Creator:: Korf, Eric A.
Abstract:: Three approaches toward the core of halichlorine and pinnaic acid are described. The first approach entails a racemic transannular nitrone-olefin [3+2] cycloaddition from nitrone 238. Construction of the nitrone 238 began with aldehyde 241. Another key feature in this route involved a ring-closing metathesis for the formation of a 14-membered...
Resource Type:: Dissertation

Development, validation and the application of a congener specific photodegradation model for PBDEs

Creator:: Zeng, Xia
Abstract:: The thermodynamic properties of 39 PBDEs have been calculated using Gaussian 03 on the B3LYP/6-31G(d)//B3LYP/6-31G(d) level. The PBDE congeners' enthalpies of formation increase with increasing number of bromines and show a strong dependence on the bromine substitution pattern. The effects of bromine substitution pattern have been quantitatively studied by GAM...
Resource Type:: Dissertation
Full Text:: , M. G.; Fischer, M.; He, T.; Addison, R. F.; Smith, T., Congener patterns, spatial and temporal

Design, characterization, and application of spectrometers for determination of low-level dissolved oxygen with small-volume sampling methodology

Creator:: Cakin, Defne
Abstract:: New analytical methods and instrumentation were developed for the determination of dissolved oxygen (DO) at low concentrations in water. The methods were based on monitoring the absorbance increase due to the oxidation of reduced indigo carmine (IC) by oxygen in the sample in different types of spectrometer cells. Spectrophotometer cells...
Resource Type:: Dissertation

Studies toward the total synthesis of alkaloids : nagelamide A and D, agelastatin D, dragmacidin A-C, salacin and almazoles

Creator:: Tonsiengsom, Sorasaree
Abstract:: Studies toward the total syntheses of highly potent cytotoxic alkaloids including the bromopyrrole alkaloids and indole alkaloids were conducted and are described. Studies carried out in the course of this dissertation consist of five total syntheses of natural products that include bromopyrrole alkaloids nagelamide A, D and agelastatin D as...
Resource Type:: Dissertation
Full Text:: including Eddie Lee, Yulong Ma, and those from the White research group, the Carter research group, and

ScholarsArchive@OSU

Total synthesis of phorboxazole A

Studies towards the total synthesis of (-)-kendomycin

Gas-phase fragmentation chemistry of protonated peptide ions

Polarization spectroscopy and photodissociation studies of nitroaromatic compounds in the gas phase

Synthesis and characterization of novel stationary phases for small scale liquid chromatographic separations of proteins and nanoparticles

Luminescent sulfides and solution-deposited oxide thin films

Studies toward the synthesis of halichlorine and pinnaic acid

Development, validation and the application of a congener specific photodegradation model for PBDEs

Design, characterization, and application of spectrometers for determination of low-level dissolved oxygen with small-volume sampling methodology

Studies toward the total synthesis of alkaloids : nagelamide A and D, agelastatin D, dragmacidin A-C, salacin and almazoles

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