Index Catalog // ScholarsArchive@OSU

[Lambda hyperon]-((R)-cysteinesulfenamido-N,S) bis (ethylenediamine) cobalt(III) complex : Characterization of the complex and kinetics and mechanism of formation and base-catalyzed decomposition

Creator:: Sanguanruang, Oravan
Resource Type:: Dissertation
Full Text:: [Lambda hyperon]-((R)-cysteinesulfenamido-N,S) bis

Studies toward the synthesis of halichlorine and pinnaic acid

Creator:: Korf, Eric A.
Abstract:: Three approaches toward the core of halichlorine and pinnaic acid are described. The first approach entails a racemic transannular nitrone-olefin [3+2] cycloaddition from nitrone 238. Construction of the nitrone 238 began with aldehyde 241. Another key feature in this route involved a ring-closing metathesis for the formation of a 14-membered...
Resource Type:: Dissertation
Full Text:: approved: James D. White Three approaches toward the core of halichlorine and

Electrochemical studies of liquid chlorocuprates(I)

Creator:: Silkey, James R.
Abstract:: This research emphasized fundamental physical and electrochemical studies of systems based on the room temperature fused salt, triethyl-ammonium dichlorocuprate(I). Such systems, which must be maintained under a protective atmosphere, were also used in some preliminary battery studies. Spectra of dark green solutions of copper (II) chloride in triethylammonium dichlorocuprate(I) obey...
Resource Type:: Masters Thesis
Full Text:: ABSTRACT OF THE THESIS OF James R. Silkey for the degree of Master of Science in Chemistry presented on

Micro total analysis system for in-situ and autonomous spectrophotometric monitoring of iron in groundwater

Creator:: Koch, Corey R.
Abstract:: We have developed a compact micro total analysis system (μTAS) to serve as a platform for in-situ spectrophotometric water quality monitoring. Individual fluidic, optical, and electrical components were designed, developed, and characterized. These components were combined in both an integrated (single lithographic “chip-based” platform) and a modular manner. The microfluidic...
Resource Type:: Dissertation
Full Text:: . _______________________________________________ Corey R. Koch, Author ACKNOWLEDGEMENTS I would like to thank James Ingle and

Cis-2,5-diaminobicyclo[2.2.2]octane : a novel C₂-symmetric scaffold for asymmetric catalysis

Creator:: Shaw, Subrata
Abstract:: This thesis describes the development of a new enantioselective synthetic method employing chiral cis-2,5-diaminobicyclo[2.2.2]octane-based organometallic catalysts. The significance of this new method to organic synthesis is illustrated with preparation of enantioenriched products that are transformed to important pharmaceutical agents. Chapter 1 provides a brief historical overview of asymmetric catalysis, especially...
Resource Type:: Dissertation
Full Text:: [2.2.2]octane: A Novel C2-Symmetric Scaffold for Asymmetric Catalysis Abstract approved: James D

Polymeric submicron optical ion-selective sensors

Creator:: Bychkova, Valeriya
Abstract:: Ion-selective polymeric optical sensors – ion optodes – are a promising alternative to ion-selective electrodes and fluorescent dyes for analytical and biological applications, e.g. extra- and intracellular measurements. They are non-toxic, highly selective robust probes for ionic fluxes monitoring. A large-scale fabrication of ion optodes using a solvent displacement method...
Resource Type:: Dissertation
Full Text:: Submicron Optical Ion-Selective Sensors. Abstract approved: James D. Ingle, Jr. Ion

Tandem intramolecular photocycloaddition-retro-Mannich fragmentation as a route to indole and oxindole

Creator:: Li, Yang
Abstract:: Irradiation of a tryptamine linked through its side-chain nitrogen to an alkylidene malonate residue results in an intramolecular [2 + 2] cycloaddition to the indole 2,3-double bond. The resultant cyclobutane undergoes spontaneous retro-Mannich fission to produce a spiro[indoline-3,3-pyrrolenine] with relative configuration defined by the orientation of substituents in the transient...
Resource Type:: Dissertation
Full Text:: approved: James D. White

Total synthesis of phorboxazole A

Creator:: Lee, Tae Hee
Abstract:: The total synthesis of a highly potent cytotoxic marine natural product, phorboxazole A, is described. Both a palladium(II)-mediated and a palladium(II)-catalyzed intramolecular alkoxycarbonylation were used as key steps for the preparation of the two cis-2,6-disubstituted tetrahydropyran rings (C22-C26 and C11-C15) of phorboxazole A. The synthesis used a convergent approach involving...
Resource Type:: Dissertation
Full Text:: : James D. White The total synthesis of a highly potent cytotoxic marine natural product

Studies toward the total synthesis of (+)-providencin

Creator:: Jana, Somnath
Abstract:: Studies toward the total synthesis of (+)-providencin (1), a highly oxygenated cembranoid dipterpene with a unique bicyclo[12.2.0]hexadecane skeleton and pronounced biological activity, are described. These studies resulted in the synthesis of advanced intermediates 320 and 332 which contain all of the carbon atoms of 1. In a first generation approach...
Resource Type:: Dissertation
Full Text:: approved: _____________________________________________________ James D. White Studies toward

Studies towards the total synthesis of (-)-kendomycin

Creator:: Smits, Helmars
Abstract:: Studies towards the total synthesis of (−)-kendomycin (1), a bacterial metabolite with a unique molecular architecture and pronounced biological activity, are described. These studies resulted in the synthesis of advanced intermediate 208, containing all of the carbon atoms of 1. A Dötz annulation between alkyne 122 and novel chromium carbenoid...
Resource Type:: Dissertation
Full Text:: :_____________________________________________________ James D. White Studies towards the total synthesis of (−)-kendomycin (1), a bacterial

Aryl acetylene substituent effects : the synthesis and application of biaryls

Creator:: Naffziger, Michael R.
Abstract:: The work described herein details the synthesis and application of biphenyls that probe the effects of hydrogen, Cl / Br, and methyl substituents on the aryl ring of the terminal acetylenic carbon. From this work, we successfully developed the rapid synthesis of phenyl acetylenes in 3-4 steps from inexpensive commercially...
Resource Type:: Masters Thesis
Full Text:: AN ABSTRACT OF THE THESIS OF Michael R. Naffziger

Development of new data collection and analysis techniques for low energy electron diffraction and their application to the Mo(110)-p(2x2)-S and Al₂O₃ (0001) systems

Creator:: Toofan, Jahansooz
Resource Type:: Dissertation
Full Text:: (2x2)-S and A1203 (0001) Systems. Abstract approved: Philip R. Watson There is a continuing need in

Part I: Synthesis and evaluation of synosutine as an inhibitor of serotonin, norepinephrine, and dopamine transporters Part II: Asymmetric approach to the tetracyclic core of neomangicol A

Creator:: Juniku, Rajan B.
Abstract:: Part I: Racemic and asymmetric syntheses of a new substance with prospective antidepressant properties were achieved. In vitro assays with synthetic racemates (±)-25 and (±)-26 suggested that the former is a relatively selective inhibitor of serotonin transporter whereas the latter is a more balanced inhibitor of both serotonin and norepinephrine...
Resource Type:: Dissertation
Full Text:: Abstract approved: _____________________________________________________ James D. White Part I

Studies towards the total syntheses of (+)-phomactins A, D and G

Creator:: Schwartz, Keith D.
Abstract:: Studies towards the total synthesis of (+)-Phomactin A (1), D (6), and G (9), fungal metabolites with unique molecular architecture and pronounced biological activity, are described. These studies resulted in the synthesis of advanced intermediates 354 and 356, which contain all of the carbon atoms of 1, 6 and 9....
Resource Type:: Dissertation
Full Text:: James D. White Studies towards the total synthesis of (+)-Phomactin A (1), D (6), and G (9), fungal

Reactions of I-(α-pyridyl)-3-buten-1-o1

Creator:: Whitman, James Edgar
Abstract:: The purpose of this project was to study the reactions of 1-(α-pyridyl)-3-buten-1-ol (compound I) and to determine whether or not the products of some of its reactions are quinolizinium salts. Reaction of compound I with bromine or iodine yields halide salts (when no external cooling is applied) instead of the...
Resource Type:: Masters Thesis
Full Text:: . M. R. identification has yet been rnade, Z) identification of soryre of the irnportant I. R. bands

Synthesis of a model of the spiroketal portion of avermectin B

Creator:: Warrier, Ulhas S.
Abstract:: Avermectin Bia is a member of a class of medicinally important natural products known for its potent antiparasitic activity and interesting structural features. In this thesis, synthesis of a model for the spiroketal portion of the avermectins is presented. Oxidation of (S)-2-methylbutanol, followed by a stereoselective chromium mediated reaction with...
Resource Type:: Masters Thesis
Full Text:: Bla Abstract approved: Redacted for privacy r Dr. James D. White Avermectin Bia is a member of a

Synthesis and oxidation of metal-thiolate compounds which mimic the active site function of thiolate dioxygenase enzymes

Creator:: Schussel, Leonard J.
Abstract:: Part I describes the synthesis of bis(fac-S)((tris)2-aminoethanethiolatoiron( III))iron(III) chloride. The compound was first discovered during an attempt to prepare a ternary complex of iron, thiolate and pi-acid ligand. The compound is a reasonably air-stable iron(III)-thiolate that contains a linear tri-iron cluster with each iron bridged to the adjacent iron by...
Resource Type:: Dissertation
Full Text:: DIOXYGENASE ENZYMES Abstract approved: Redacted for Privacy Dr. James H. Krueger Part I describes the

Reactions and stereochemistry of thiolato and sulfenato cobalt (III) complexes

Creator:: Herting, Daniel L.
Abstract:: This thesis describes a study of the synthesis, stereochemistry, and reactivity of cobalt(III) cysteinato (CyS) and related thiolato complexes. The preparation of [Co(en)₂CyS]⁺ resulted in a product solution containing a mixture of diastereomers in the ratio 2.3:1 (Δ:A). The isomers were separated by ion exchange chromatography, and their absolute configurations...
Resource Type:: Dissertation
Full Text:: A-[Co(en)2CyS] + by H202 led to a 2.9 :1 (S:R) mixture ofAS- and AR- { Co(en)2(CyS0)1+, the S and R

Total synthesis of (-)-7-epicylindrospermopsin

Creator:: Hansen, Joshua D.
Abstract:: The first asymmetric synthesis of (-)-7-epicylindrospermopsin via intramolecular nitrone cycloaddition is described. The synthesis utilized a convergent approach to prepare the cycloaddition precursor 176, which was assembled by condensation of hydroxylamine 175 with aldehyde 145. Hydroxylamine 175 was synthesized from ethylene glycol (166) in seven steps. Aldehyde 145 was completed...
Resource Type:: Dissertation
Full Text:: approved: _____ } U ! James D. White The first asymmetric synthesis of (-)-7-epicylindrospermopsin via

Studies on the synthesis of the "northern" and "southern" segments of boromycin and aplasmomycin

Creator:: Kang, Myung Chol
Abstract:: The stereocontrolled synthesis of the southern lactone 17 of boromycin and of the northern segments of both boromycin and aplasmomycin are described. The syntheses begin with enantioselective epoxidation of 3-buten-2-ol (42) to provide the optically active 2(S),3(R) epoxy alcohol 43. The absolute configuration was confirmed by preparing 43 from (-)-2,3-dihydroxybutyric...
Resource Type:: Dissertation
Full Text:: for privacy Dt. James D. White The stereocontrolled synthesis of the southern lactone 17 of

Synthesis of metabolites from the ascomycetes : I. The synthesis and absolute configuration of leptosphaerin : II. Approaches to the synthesis of byssochlamic acid

Creator:: Pallenberg, Alexander J.
Abstract:: Part I. The total synthesis of (+)-leptosphaerin (2), a metabolite of the marine Ascomycete Leptosphaeria Oraemaris (Linder) was achieved, unambiguously establishing both the relative and absolute stereochemistry of this natural product. This synthesis also resolved the long-standing question of which of the isomeric structures 1 or 2 correctly represents the...
Resource Type:: Dissertation
Full Text:: Redacted for privacy Abstract approved: James D. White Part I. The total synthesis of (+)-leptosphaerin

Approaches to the synthesis of methymycin

Creator:: Raghavan, Palaykotai Rajagopalan
Abstract:: Several approaches to the synthesis of methymycin were investigated. Segment A (39), containing functionality corresponding to C-9, 10, and 11 of methynolide was made in six steps from propionaldehyde in an overall yield of 37%. Oxidation of 34 with silver nitrate gave 35 which, upon hydroxylation with hydrogen peroxide, gave...
Resource Type:: Dissertation
Full Text:: approved: Dr. James D. White Several approaches to the synthesis of methymycin were investigated

Absolute stereochemistry and total synthesis of botryococcene

Creator:: Reddy, Guvvala Nagabhushana
Abstract:: Studies were carried out to determine the absolute stereochemistry of botryococcene (1). The natural product was degraded to two sets of 'y- and 8- valerolactones. All enantiomeric variations of these lactones were synthesized in optically pure form starting from (S)- and (R)-methyloxiranes. 1H NMR correlation of natural and synthetic materials...
Resource Type:: Dissertation
Full Text:: Botryococcene Abstract approved: Pedacted for Privacy Li James D. White Studies were carried out to determine

Synthesis of two subunits of avermectin B1a

Creator:: Dantanarayana, Anura Pathmasiri
Abstract:: Avermectins are a group of potent anthelmintic agents produced by Streptomyces avermitilis. They are active at extremely low dosages and are now in commercial use. In this study, the synthesis of two segments of avermectin B[subscript 1a] are described. The synthesis of the hexahydrobenzofuran subunit (segment A) began with the...
Resource Type:: Dissertation
Full Text:: approved: Redacted for privacy (it James D. White Avermectins are a group of potent anthelmintic agents

Approaches to the synthesis of the macrolactone pyrrolizidine alkaloids (-)-integerrimine and (+)-usaramine

Creator:: Jayasinghe, Lalith Ratnasiri
Abstract:: A formal total synthesis of the macrolactone pyrolizidine alkaloid (-)-integerrimine (2), from R-(+)-citronellal (93) is described. Aldehyde 93 was converted to exo methylene derivative 94 which was reduced to allylic alcohol 95. The epoxides 96 and 98, obtained in a ratio of 3:1 respectively by Sharp less epoxidation of 95...
Resource Type:: Dissertation
Full Text:: . Redacted for privacy Abstract approved: James D. White A formal total synthesis of the macrolactone

The chemical nature of the "lignin" of the bark of Douglas fir, Pseudotsuga menziesii (Mirb.) Franco

Creator:: Smith, James E. (James Edward)
Resource Type:: Dissertation
Full Text:: DOUGLAS FIR, · PSEUDOTSUGA MENZIESII (MffiB.) FRANCO by JAMES EDWARD ITH A THESIS submitted to

The nature of the chemical constituents of incense cedar, Libocedrus decurrens (Torr.) bark

Creator:: Smith, James E. (James Edward)
Abstract:: The purpose of this investigation was to determine the nature of the chemical constituents of incense cedar bark with the hope that such an endeavor would spur future research, development and use of a now neglected natural raw material. The bark from nine trees, which were separated into three age...
Resource Type:: Masters Thesis
Full Text:: , (Libocedrus Decurrens Torr.) Bark AN ABSTRACT OF THE THESIS OF James Edward Smith for the U.S. in

The kinetic and radiolytic aspects of control of the redox speciation of neptunium in solutions of nitric acid

Creator:: Precek, Martin
Abstract:: Neptunium, with its rich redox chemistry, has a special position in the chemistry of actinides. With a decades-long history of development of aqueous separation methods for used nuclear fuel (UNF), management of neptunium remains an unresolved issue because of its not clearly defined redox speciation. Neptunium is present in two,...
Resource Type:: Dissertation
Full Text:: to the past and present members of my doctoral committee at OSU: Dr. James D. Ingle, Dr. Walter D

Synthetic approaches to the tricarbonyl subunit of rapamycin

Creator:: LaMunyon, James B.
Abstract:: Rapamycin (5) was isolated in 1975 from the soil bacteria Streptomyces hygroscopicus and its structure was determined from spectroscopic techniques and an x-ray crystallographic analysis. Although it was initially found to exhibit antibiotic activity, it was subsequently shown to possess potent immunosuppressive activity as well. Three approaches to the synthesis...
Resource Type:: Masters Thesis
Full Text:: AN ABSTRACT OF THE THESIS OF James B. LaMunyon for the degree

Approaches to the synthesis of trichothecane sesquiterpenes

Creator:: Thomas, James Anthony
Resource Type:: Dissertation
Full Text:: sesquiterpenes AN ABSTRACT OF THE THESIS OF James Anthony Thomas for the degree of Doctor of Philosophy in

The rotational motion of molecules in crystalline solids

Creator:: Miller, R. E.
Abstract:: Theoretical studies and experimental results are presented for the rotational motion of molecule's in crystalline solids. The group theory is solved for molecules of any symmetry matrix isolated at a site in a crystal field of any symmetry. As the potential terrier to rotation of the molecule relative to the...
Resource Type:: Dissertation
Full Text:: support to the evidence for rotation and the James-Keenan model for the lowest temperature phase of neat

Design and application of a microcomputer automated multielement flame atomic fluorescence instrument

Creator:: Neyzari, Shahrokh Ghaffari
Abstract:: An automated multielement flame atomic fluorescence (AF) spectrometer based on microcomputer control was constructed to determine four elements simultaneously. The instrument employs a multiple exit slit monochromator where the light from various exit slits is directed to a single detector with a mirrored funnel. Each element is excited to fluoresce...
Resource Type:: Dissertation
Full Text:: (Ghaemi) Ghaffari Whom I (X)' the most, With special thanks to Dr. James D. Ingle, my thesis advisor

Studies toward the total synthesis of sanglifehrin A

Creator:: Suttisintong, Khomson
Abstract:: Studies toward synthesis of subunits of sanglifehrin A, an immunosuppressant featuring a highly substituted [5,5]-spirolactam moiety as well as a 22-membered macrocycle are described. The macrolactone contains a peptidic backbone characterized by an unusual [beta]-substituted (S)-piperazic acid and (S)-m-hydroxyphenylalanine units. These studies resulted in the synthesis of advanced intermediate 358...
Resource Type:: Dissertation
Full Text:: :______________________________________________________ James D. White Studies

Characterization and applications of polyphenol chemiluminescence reactions and flow cell instrumentation

Creator:: Miller, Robert J. (Robert James), 1933-
Resource Type:: Dissertation
Full Text:: chemiluminescence reactions and flow cell instrumentation AN ABSTRACT OF THE THESIS OF Robert James Miller for

Studies toward the total synthesis of phorboxazole A

Creator:: Kuntiyong, Punlop
Abstract:: Studies toward the total synthesis of a highly potent cytotoxic marine natural product, phorboxazole A, were conducted and resulted in a route to an advanced intermediate, C4-C32, for this purpose. A key feature of our approach is the stereoselective synthesis of two cis-2,6-disubstituted tetrahydropyrans present in the macrolide portion of...
Resource Type:: Dissertation
Full Text:: TOTAL SYNTHESIS OF PHORBOXAZOLE A. Abstract approved: James D. White Studies toward the total

Total synthesis of indole alkaloids: pt. 1. Asymmetric synthesis of (-)-ibogamine. pt. 2. An approach toward the synthesis of koumine

Creator:: Choi, Younggi
Abstract:: PART I. The preparation of (-)-ibogamine (1) in fourteen steps from benzoquinone and in 10% overall yield is a powerful illustration of the value of the asymmetric Diels-Alder reaction as a starting point in a multistep synthesis. All four cycloadducts, 70, 77, 84 and 96, obtained with the (S)-BINOL-TiCl₂ complex...
Resource Type:: Dissertation
Full Text:: SYNTHESIS OF KOUMINE. Abstracted approved: James D. White PART I. The preparation of ()-ibogamine (1) in

Synthetic studies on natural products : Part I. The total synthesis of ±-euonyminol and ±-3,4-dideoxymaytol : Part II. The absolute configuration and enantioselective synthesis of curacin A

Creator:: Kim, Tae-Seong
Resource Type:: Dissertation
Full Text:: Synthesis of Curacin A . Abstract approved: James D. White Part I. The determination of the absolute

A reaction rate determination of aluminum with a microcomputer-based spectrofluorometer

Creator:: Campi, Gregory Louis
Abstract:: The development and optimization of a fluorometric reaction rate method for the determination of aluminum is described. Modifications to existing instrumentation permit automatic monitoring and reporting of measurement conditions. Automatic correction of measured analytical signals is provided if monitored parameters deviate from optimum values. A computer controlled standard addition procedure...
Resource Type:: Masters Thesis
Full Text:: called AAGR (acid alizarian garnet R) or Garnet Y. Figure 1 shows the structure of the dye and the

Approaches toward synthesis of the mycosporins

Creator:: Cammack, Janice H.
Abstract:: The mycosporins, formerly called P310's are secondary metabolites of fungi closely associated with fungal reproductive processes that require light. The structurally related iminomycosporins are found in marine plants and animals and may also have functions related to light. In this study, approaches toward the asymmetric synthesis of the mycosporins are...
Resource Type:: Dissertation
Full Text:: . James D. White Abstract approved: The mycosporins, formerly called P310's are secondary metabolites

Synthetic studies on marine natural products : I. Stereoselective synthesis of E,Z-1,3-Dienes by tandem nucleophilic addition to a dienylphosphonium salt followed by Wittig reaction. II. Synthesis of cyclopropyl oxylipins by a cation mediated carbocyclization

Creator:: Jensen, Mark S.
Resource Type:: Dissertation
Full Text:: approved: James D. White I. A new stereoselective route for the synthesis of E,Z-1,3-dienes using a

Studies towards the total synthesis of (-)-gymnodimine

Creator:: Wang, Guoqiang
Abstract:: Studies towards the total synthesis of (-)-gymnodimine (1), a marine neurotoxin with a unique molecular architecture and pronounced biological activity, are described. These studies resulted in a convergent approach to the advanced intermediate 315, containing the C3-C32 section of 1. Two synthetic routes were developed to construct the tetrahydrofuran subunit...
Resource Type:: Dissertation
Full Text:: Total Synthesis of ()-Gvmnodimine Abstract James D. White Studies towards the total synthesis of

Approaches to the synthesis of polyketides. Vermiculine

Creator:: Kirkemo, Curtis Lee
Abstract:: An approach to the generation of polyketides was investigated, which involved ozonolysis of 6, 7 cyclopenteno -1> 4, 5, 8 -tetrahydromethoxy- 3-methylnaphthalene (26), to produce what is believed to be polyketide 27. Compound 26 was formed by the following sequence: Die ls -Alder addition of 1, 2 -dim.ethylenecyclopentane and 2...
Resource Type:: Dissertation
Full Text:: SYNTHESIS OF POLYKETIDES. VERMICULINE. Redacted for privacy Abstract approved: Dr. James D. White An

Synthetic studies on the macrolide antibiotic rutamycin B

Creator:: Wang, Shan
Resource Type:: Dissertation
Full Text:: approved: J James D. White Part I. Five approaches, including two successful routes, toward the

Synthesis of epothilones and epothilone analogues

Creator:: Sundermann, Kurt F.
Abstract:: A convergent synthesis of epothilone B that generates all seven of its asymmetric centers in a completely stereoselective fashion has been completed. Key reactions include an anti-Felkin aldol condensation to set the C6 and C7 stereochemistry, a directed α-hydroxylation to install the C15 (S)-hydroxyl substituent, and a Wittig condensation to...
Resource Type:: Dissertation
Full Text:: sincere appreciation to Dr. Richard G. Carter, Dr. Duncan J. Wardrop, and Professor James, D White for

Development of automated flow injection apparatus and a novel flow cell for chemi- and bioluminescence determinations

Creator:: Gander, Stuart C.
Abstract:: A practical and versatile instrument has been developed both to optimize the chemistry of bio- and chemiluminescence reactions and to measure ultra-trace quantities of associated analytes. The instrument consists of a pneumatic flow injection system linked to a detection cell and a signal processing and readout system. The disk-like cell...
Resource Type:: Masters Thesis
Full Text:: Determinations . Redacted for Privacy Abstract approved: Dr. James D. Ingle, Jr. A practical and versatile

The synthesis of macrolactones from [omega]-hydroxyacyl xanthates

Creator:: Akella, Annapoorna
Resource Type:: Masters Thesis
Full Text:: Xanthates Redacted for Privacy Abstract approved: James D. White The synthesis of macrolactones from 0

Approaches to the synthesis of penicillin

Creator:: Furuta, Takuya
Abstract:: Several approaches to the synthesis of penicillin from 2-iminothioazolidine 50, from 2-thiothiazolidine 66 and by photocyclization of 77 and 78 were investigated. 2-Iminothiazolidine 50 was prepared from dibromoester 45 by the action of benzylamine followed by treatment of aziridine 46 with potassium or ammonium thiocyanate. Attempted introduction of a two-carbon...
Resource Type:: Dissertation
Full Text:: . James D. White Several approaches to the synthesis of penicillin from 2-imino- thioazolidine 50, from

Asymmetric synthesis of cyclopropanes via a "zipper reaction"

Creator:: Lincoln, Christopher M.
Abstract:: The rearrangement of a homoallyl cation to a cyclopropylcarbinyl cation is thought to play a role in the biogenesis of a variety of cyclopropane-containing natural products,¹ a hypothesis which has previously led to the design of successful biomimetic syntheses of several natural products.² The strategy underlying this approach to cyclopropane...
Resource Type:: Dissertation
Full Text:: Synthesis of Cyclopropanes via a "Zipper Reaction" Abstract approved: James D. White The rearrangement of

Structural and synthetic studies of higher terpenoids : Part I. The absolute configuration of (-)-botryococcene : Part II. Total synthesis of (±)-2-desoxystemodinone

Creator:: Somers, Todd Charles
Resource Type:: Dissertation
Full Text:: . Redacted for Privacy Abstract approved: U James 0. White Part I. Complete structural and stereochemical

Part I. The total synthesis of (±)-cinnamodial and related drimane sesquiterpenes; Part II. Photochemical activation of the carboxyl group via N-Acyl-2-thionothiazolidines

Creator:: Burton, Lester Percy Joseph
Resource Type:: Dissertation
Full Text:: NAcy1-2-thionothiazolidines Abstract approved: Redacted for privacy DT. James D. White Part I A total

Nuclear magnetic resonance investigation of acidic proton behavior in phenylsulfonylacetone and acetohydroxamic acid

Creator:: Stanclift, William Everett
Resource Type:: Masters Thesis
Full Text:: chloroforrn solutions of stoichiornetric rnixtures of the arnine and sulfone, when analyzed by r. rn. r

Synthetic studies on marine natural products : Part 1. Synthesis of the sesquiterpenoid dihydropallescensin D via manganese(III)- mediated carbocyclization. Part 2. Approaches toward the synthesis of prianosin and discorhabdin alkaloids

Creator:: Yager, Kraig M.
Resource Type:: Dissertation
Full Text:: Prianosin and Discorhabdin Alkaloids. Abstract approved: 1 James D. White Part 1. The synthesis of

The synthesis of trisporic acids

Creator:: Prisbylla, Michael Paul
Abstract:: A total synthesis of the fungal hormones, trisporic acids A and B, is described, starting from a -methyltetronic acid 34. A Robinson annelation of 34 with ethyl vinyl ketone affords the lactone 33. Treatment of 33 with N-bromosuccinimide gave 97, which was hydrolyzed to the lactol 103. The reaction of...
Resource Type:: Dissertation
Full Text:: 13, 1977 Title: THE SYNTHESIS OF TRISPORIC ACIDS Abstract approved: Redacted for Privacy Dr. James

Synthetic studies on necic acids of pyrrolizidine alkaloids

Creator:: Lee, Nadine Chauyi
Resource Type:: Dissertation
Full Text:: Alkaloids Abstract approved: James D. White An asymmetric synthesis of (+)-nemorensic acid (25) is

The total synthesis of (-)- acorenone B ; Approaches to the synthesis of mycosporin (P 310)

Creator:: Ruppert, John Fredrick
Resource Type:: Dissertation
Full Text:: : Redacted for Privacy Dr, James D. White An improved technique for synthesis of p-hydroxy esters via the

The synthesis of nonactic acid

Creator:: Arco, Manuel Jose
Abstract:: Alkylation of propylene oxide with 2-lithiofuran gave alcohol I, which was smoothly converted to acetylfuran II. hydrogenation of II over rhodium on charcoal followed by Jones' oxidation afforded ketone III. Further transformation into IV was accomplished via a Wittig reaction followed by saponification with methanolic sodium hydroxide. Hydroboration of the...
Resource Type:: Dissertation
Full Text:: NONACTIC ACID Abstract approved: Redacted for privacy I James D. White Alkylation of propylene oxide

Kinetics and mechanisms of nucleophilic displacement reactions with S-methyl-S-phenyl-sulfiminium perchlorate

Creator:: KiYokane, Richard Junji
Resource Type:: Masters Thesis
Full Text:: ACKNOWLEDGEMENTS I wish to express my appreciation to Dr. James H. Krueger for his guidance and encouragement

Total synthesis of (+)-bourgeanic acid and conformational analysis of its dilactone

Creator:: Johnson, Alan T. (Alan Thomas), 1957-
Resource Type:: Dissertation
Full Text:: Conformational Analysis of its Dilactone Abstract approved: _Redacted for Privacyj James u. wnite The total

Intramolecular diels-alder cycloadditions of citraconic and mesaconic esters ; Studies on the synthesis of the northwest and southeast segments of boromycin

Creator:: Sheldon, Bernard Gale
Resource Type:: Dissertation
Full Text:: BOROMYCIN Redacted for privacyAbstract approved: Dr. James D. White The thermal cycloaddition of trans

Synthesis of furanoeremophilane sesquiterpenoids

Creator:: Shanmugham, Meenakshi Sundaram
Abstract:: Two approaches to the tricyclic core of the furanoeremophilane sesquiterpenoids are described. The first approach entails a projected Diels-Alder/retro Diels-Alder reaction of an acetylenic oxazole 64. Construction of the pivotal aldehyde 67 commenced from ketone 68. The acetyenic moiety was then introduced via a Felkin-Ahn addition of lithiopropyne to aldehyde...
Resource Type:: Dissertation
Full Text:: FURANOEREMOPHILANE SESQUITERPENOIDS Abstract approved: James D. White Two approaches to the tricyclic core of the

Studies of chemical speciation of trace metals in natural waters using an on-line electrochemical cell and ion exchange system

Creator:: Sule, Pushkar Anant
Resource Type:: Masters Thesis
Full Text:: and Ion Exchange System Abstract approved: Redacted for privacy James D. Ingle, Jr. A flow-through

Theoretical and experimental factors affecting the accuracy and precision of atomic absorption measurements

Creator:: Bower, Nathan Wayne
Abstract:: A procedure for evaluating the precision of atomic absorption measurements is presented and applied to 21 elements under varying instrumental conditions. The experimental relative standard deviations (RSD's) in absorbance obtained from repetitive measurements made with a high resolution voltmeter and on-line computer, are compared to those predicted by a recently...
Resource Type:: Dissertation
Full Text:: decreases to 0 at higher frequencies. H(f) is determined by the conglomerate of resistances (R

Partial chemical speciation techniques for aquatic humic-metal complexes

Creator:: Chase, Duane Scott
Resource Type:: Masters Thesis
Full Text:: Humic-Metal Complexes Abstract approved: Redacted for privacy James D. Ingle, Jr., Associate

Characterization of a trivalent-nitrogen center. Nucleophilic substitution on hydroxylamine-o-sulfonic acid in dimethyl sulfoxide-water solvents

Creator:: Sudbury, Barry Arnold
Resource Type:: Dissertation
Full Text:: reaction of (C6H5)3P with H2NOS03- on DMSO mole fraction. 99 15. A plot of kHOSH versus 1 /[r

Phenolic oxidative coupling : an approach to the synthesis of pretazettine

Creator:: Chong, Wesley Kwan Mung
Abstract:: Various hypervalent iodine compounds were evaluated as reagents for intramolecular phenolic oxidative coupling. It was found that phenyliodine(III) bis(trifluoroacetate) was effective for the coupling of the monophenolic substrate 13a to 14a under neutral conditions. Vanadium oxytrifluoride and hypervalent iodine compounds were compared as oxidants for the conversion of 32 to...
Resource Type:: Dissertation
Full Text:: the Synthesis of Pretazettine. Redacted for Privacy Abstract approved: Di. James D. White Various

Part I : synthesis of azetidin-2-ones from pyrazolidin-3-ones ; Part II : synthesis of a subunit of the immunosuppressant FK-506

Creator:: Toske, Steven Gerald
Resource Type:: Dissertation
Full Text:: Immunosuppressant FK-506. Abstract approved: James D. White Part I. A new route for the preparation of azetidin-2

A kinetic investigation of the hydrolysis of trimethylamine-sulfur trioxide in dimethyl sulfoxide-water solvents

Creator:: Johnson, William Allen
Resource Type:: Dissertation
Full Text:: (CH3)3NSO3 + H20 -----=r (CH3)3NH+ + HSO4- In the presence of added hydroxide ion the stoichiometry

Synthetic studies of nonadrides

Creator:: Drapela, Nicholas Ernest
Abstract:: An asymmetric approach to the synthesis of byssochlamic acid (1) is described. Regioisomeric enzymatic differentiation is described in the selective hydrolysis of dimethyl ester 30 by porcine liver esterase. Chiral dimethyl ester 42 was prepared by desymmetrization of cyclopentene 34 using porcine liver esterase. A key intramolecular [2+2]cycloaddition-cycloreversion photometathesis of...
Resource Type:: Dissertation
Full Text:: 14 1998. Title: Synthetic Studies of Nonadrides Abstract approved: James D. White An asymmetric

Oxidation of ethanol and phenols with permanganate for chemiluminescence analysis

Creator:: Al-Mutawah, Jameela Isa
Resource Type:: Masters Thesis
Full Text:: Permanganate for Chemiluminescence Analysis Abstract approved: James D. Ingle, Jr. This thesis is

Part I : development and application of an arsenic speciation technique using ion-exchange solid phase extraction coupled with GFAAS ; Part II : investigation of zinc amalgam as a reductant

Creator:: Bos, Mark C.
Abstract:: Two related techniques, based upon ion-exchange solid phase extraction, have been developed for the determination of arsenic speciation. The inorganic arsenic species arsenite (As(III)) and arsenate (As(V)) are separated by anion-exchange and detected with graphite furnace atomic absorption spectrophotometry (GFAAS) with a nickel matrix modifier. The first separation technique, which...
Resource Type:: Masters Thesis
Full Text:: Amalgam as a Reductant Abstract approved: James D. Ingle Jr. Two related techniques, based upon ion

Synthesis and oxidation of cysteine- and penicillamine- containing Fe(III) and Co(III) complexes. Analogs for the active metal sites of the cysteine and cysteamine dioxygenases

Creator:: Miller, Krys J.
Abstract:: The first part of this thesis describes a study of the characteristics of oxidation of a 1:2 iron(III):thiolate system in methanolic solution and in water. This system was investigated as a potential analog for the cysteine- and cysteamine-dioxygenase catalyzed 0₂-oxidation of cysteine and cysteamine, respectively, to the corresponding sulfinic acids....
Resource Type:: Dissertation
Full Text:: of Chemistry in ch r of major Redacted for Privacy Chairman of Department of Chemistry Redacted

Analytical chemiluminescence measurements and instrumentation

Creator:: Marino, Dean Frank
Resource Type:: Dissertation
Full Text:: James Ingle for putting up with my ravings and still managing to teach me something. Joan Marino for

Nucleophilic substitution at nitrogen : mechanisms and intermediates involved in substitution reactions of the hydroxylamine-o-sulfonate ion

Creator:: Blanchet, Pierre François
Resource Type:: Dissertation
Full Text:: SUBSTITUTION REACTIONS OF THE HYDROXYLAMINE-0- SULFONATE Redacted for privacy Abstract approved: James H

Microcomputer controlled chemical and radiochemical separations and analysis

Creator:: Bennett, Casey Wayne
Abstract:: An automated radiochemical flow analysis (ARFA) system was developed which integrates chemical and radiochemical techniques into one system through the use of a microcomputer. The operator, through the microcomputer, controls valves and pumps to transfer sample and reagent solutions to counting loops, ion exchange columns and holdup reservoirs. A Ge(Li)...
Resource Type:: Dissertation
Full Text:: Radiochemical Separations and Analysis Abstract approved: Redacted for Privacy James -D. Ingle, Jr

Development of automated on-line ion exchange systems for the determination of chemical speciation of trace metals in natural waters

Creator:: Liu, Yan
Abstract:: An automated on-line ion exchange trace enrichment system has been developed to improve the detection limits of flame atomic absorption (AA) spectrophotometry in the determination of trace metals in natural waters. The sample solution is passed through a column of Chelex-100 chelating resin by a carrier buffer stream delivered from...
Resource Type:: Dissertation
Full Text:: Speciation of Trace Metals in Natural Waters Abstract approved : Redacted for privacy James D. Ingle, Jr

An approach toward the synthesis of euonyminol and cathedulin K- 19

Creator:: Shin, Hyunik
Abstract:: A synthetic approach toward the two major fragments of cathedulin K-19, euonyminol (4) and dimethyl cathate (69), was investigated. Synthesis of dimethyl cathate was accomplished in 3 steps starting from 73. Efforts directed towards the synthesis of euonyminol, a highly oxygenated dihydroagarofuran sesquiterpene, was advanced to a stage in which...
Resource Type:: Dissertation
Full Text:: , Chaehee, and Jaesoon Acknowledgements I would like to sincerely thank professor James D. White for the

Chiral synthesis of alcohols via asymmetric epoxidation

Creator:: Engebrecht, Jeffrey Ronald
Abstract:: Enantioselective epoxidation of crotyl alcohol, followed by a cuprate mediated methylation, gave a 1:1 mixture of (2S) -3- methyl -1,2- butanediol and (2R,3S)-2-methy1-1,3- butanediol. The latter was separated as its 2,4,6-trimethylbenzenesulfonate derivative and converted via the iodide to the corresponding phosphonium salt. The separated butanediol derivatives were independently transformed to...
Resource Type:: Masters Thesis
Full Text:: AN ABSTRACT OF THE THESIS OF Jeffrey R. Engebrecht for the degree of Master of Science in Chemistry

Kinetics and mechanisms of displacement reactions involving trithionate ion

Creator:: Ritter, Ronald Dale
Resource Type:: Dissertation
Full Text:: defined as the log (R n /RH0) with R representing the 2 molar refractivity. The coefficients a' and p

Natural product synthesis via cyclobutanes : part I, Asymmetric synthesis of (+)-byssochlamic acid, part II, An approach to the nootropic agent huperzine A

Creator:: Kim, Jungchul
Abstract:: PART I. Asymmetric syntheses of both natural (+)- and nonnatural (-)-byssochlamic acid via a [2+2] photoaddition-cycloreversion strategy are described. X-ray crystallographic analysis of the cyclohexylamine salt 99 showed that the structure of the monomethyl ester 100 from esterase hydrolysis of 44 was originally misassigned as 56. The enantiomeric relationship of...
Resource Type:: Dissertation
Full Text:: approved: James D. White PART I. Asymmetric syntheses of both natural (+)- and nonnatural

A microcomputer automated anodic stripping voltammetric analyzer for trace heavy metal speciation

Creator:: Dewald, Lamar Robert
Abstract:: An automated instrument based on a single-board microcomputer was developed for use in voltammetric analyses. Operator input of numerous experiment parameters allows any type of voltammetric analysis to be implemented and multiple scans to be run unattended. A three operational amplifier potentiostat is used to control the cell voltage and...
Resource Type:: Dissertation
Full Text:: Privacy Date thesis is presented March 9, 1984 Typed by Mary Ann (Sadie) Airth for Lamar R. Dewald

Cyclization of olefinic β-ketoesters. An approach to the synthesis of aplysistatin

Creator:: Skeean, Richard William
Resource Type:: Dissertation
Full Text:: . An Approach to the Synthesis of Aplysistatin Abstract Approved: Redacted for privacy 7/ Dr. James D

Synthesis of marine natural products. part I, Cryptophycins-1, -3, -4, -24, and -29, part II, Polycavernoside A

Creator:: Robarge, Lonnie A.
Resource Type:: Dissertation
Full Text:: A. Abstract approved:, James D. White Part 1: A convergent synthesis of cryptophycins has been

Fiber optic sensors and spectrometry for the detection of volatile gem-polyhalogenated hydrocarbons

Creator:: Louch, Jeff
Abstract:: A fiber optic fluorometer utilizing a double-fiber optic probe was constructed. The absolute fluorescence signal and effective collection efficiency are approximately one fifth those of typical cuvette fluorometers and agree with those predicted by theory. A quinine sulfate calibration curve shows linearity from a detection limit of 10 pg/mL to...
Resource Type:: Dissertation
Full Text:: Privacy James D. Ingle, Jr. A fiber optic fluorometer utilizing a double-fiber optic probe was

Condensation of crotonic and tiglic acids with aldehydes and ketones

Creator:: Johnson, Paul Robert
Resource Type:: Masters Thesis
Full Text:: and Ketones Abstract approved: Redacted for Privacy James D. White 3,3-Dimethoxy-2,2

Approaches to the synthesis of trichothecenes

Creator:: Kim, No-soo
Resource Type:: Dissertation
Full Text:: June 8. 1992. Title: Approaches to the Synthesis of Trichothecenes Abstract approved: Dr. James D

The determination of gasoline and alkyl benzenes in aqueous solution and the development of a remote reaction chamber for fiber optic remote sensing

Creator:: Waddle, Robert D.
Abstract:: The development and optimization of a single-phase derivatization technique for small ring aromatics in water are presented. Also described are the design, optimization and application of a remote reaction chamber for fiber optic sensing. Aqueous solutions of the major aromatic compounds in gasoline are derivatized to o-nitrosophenol-Cu complexes with a...
Resource Type:: Masters Thesis
Full Text:: 8.5 52.4 C 37.6 3.4 59.0 D 43.7 7.8 48.5 14 aMiller, R. L., J. Chromatogr., 264, (1983) 19-32 15

Microcomputer-based fluorometric kinetic determination of ascorbic acid and flow injection analysis methods for interference correction and kinetic determinations based on the peak profile

Creator:: Chung, Hyung-Keun
Resource Type:: Dissertation
Full Text:: . 1968, 17. S. R. Crouch, Anal. Chem. 1969, 41, 880 18. G. E. James and H. L. Pardue, Anal. Chem. 1969

Synthetic studies on alkaloids : part I; asymmetric synthesis of (±) codeine. Formal synthesis of (±) morphine : part II; a unified asymetric approach toward synthesis of polyhydroxylated pyrrolizidine alkaloids, australine and alexine

Creator:: Hrnciar, Peter
Resource Type:: Dissertation
Full Text:: Alexine. Abstract approved: James D. White Part I. An asymmetric synthesis of the unnatural enantiomer

Alkylation studies on Hagemann's ester: an approach to the synthesis of the trisporic acids

Creator:: Sung, Wing Lam
Abstract:: Sequential alkylation of Hagemann's ester with methyl and methallyl halides has been studied. Treatment of Hagemann's ester with methyl iodide and sodium ethoxide gave a mixture of 21 and 25 in a ratio of 4:1. Alkylation of 21 with methallyl chloride and potassium t-butoxide afforded a mixture of 37 and...
Resource Type:: Masters Thesis
Full Text:: Privacy James D. White Sequential alkylation of Hagemann's ester with methyl and methallyl halides has

The kinetics of the reaction between peroxydisulfate and iodide ions in dimethyl sulfoxide

Creator:: Burns, Bruce
Resource Type:: Masters Thesis
Full Text:: OH + x2 -3 b OH + x (4b) k x- + S2082 -3 SO42 + SO4 + x (5) x r+ SO4 T SO42 x (6) 2 -] dl tx

Development of chemostats and use of redox indicators for studying redox transformations in biogeochemical matrices

Creator:: Lemmon, Teresa L.
Resource Type:: Dissertation
Full Text:: Matrices. Abstract approved. James D. Ingle Jr. Two sophisticated reactor systems were developed for

The determination of free chloride utilizing chemiluminescence with continuous flow and flow injection analysis

Creator:: Glaser, Soren J.
Resource Type:: Masters Thesis
Full Text:: the oxidation of r to 12 by chlorine. This method has been reported to be responsive to any strong

The isolation and structure of leptosphaerin : a metabolite of the marine ascomycete, Leptosphaeria oraemaris (Linder) and A synthesis of the marine toxin, 9-isocyanopupukeanane

Creator:: Schiehser, Guy Alan
Abstract:: The ethyl acetate extract of the culture filtrate of the marine Ascomycete, Leptosphaeria oraemaris (Linder) yielded a novel metabolite designated by the common name leptosphaerin. An x-ray crystallographic structure analysis was disproved by the synthesis of 3-acetoxy-S-(1,2-dihydroxyethyl)- 3-pyrrolin-2-one 1, starting with N,N-dibenzylhydroxylamine 47 and D-mannitol 44. Oxidation of 47 followed...
Resource Type:: Dissertation
Full Text:: -ISOCYANOPUPUKEANANE Abstract approved: Redacted for Privacy U Dr. James D. White The ethyl acetate extract of the

Approaches toward the asymmetric synthesis of pillaromycin A

Creator:: Nolen, Ernest G.
Resource Type:: Dissertation
Full Text:: A. Abstract approved: Redacted for Privacy ()James D. White Pillaromycin A, an antibiotic natural

Synthetic studies n bioactive natural products. Part I, An approach towards the nootrophic agent huperzine A. Part II, Synthesis of the tricarbonyl subunit of rapamycin

Creator:: Jeffrey, Scott C.
Resource Type:: Dissertation
Full Text:: Rapamycin. Abstract approved: James D. White Part I. Two approaches towards the bicyclic framework of

Continuous sample flow and mercury (II) speciation studies utilizing the cold vapor atomic absorption method for mercury determination

Creator:: Oda, Carl Ekio
Resource Type:: Masters Thesis
Full Text:: for Mercury Determination Redacted for Privacy Abstract approved: James D. Ingle, Jr., Associate

Approaches to the total synthesis of verrucarol

Creator:: Hill, David E. (David Edwin) 1954-
Abstract:: Verrucarol is the sesquiterpene portion of a number of macrocyclic di- and triesters of potential medicinal importance. In this study, a novel approach to the synthesis of this fungal metabolite is presented. An A-B-C route was investigated in which C-3 and C-4 of the C-ring were emplaced using a [2+2]...
Resource Type:: Dissertation
Full Text:: privacy (Pr. James D. White Verrucarol is the sesquiterpene portion of a number of macrocyclic di- and

Chiral synthesis of monic acid C

Creator:: Theramongkol, Parinya
Abstract:: Bromoalkoxylation of dihydropyran with bromine and 1-borneol, followed by dehydrobromination and epoxidation, afforded trans-2-1- bornyloxy-3,4-epoxytetrahydropyran as a major product. This was treated with sodium phenylselenide to give a 1:1 mixture of (2R,3R,4R)- 2-1-bornyloxy-3-hydroxy-4-phenylselenotetrahydropyran and its (2S,3S, 4S) diastereomer. Elimination of the selenoxide, derived from oxidation of the former with hydrogen...
Resource Type:: Dissertation
Full Text:: ,,, James D. White Bromoalkoxylation of dihydropyran with bromine and 1-borneol, followed by

Development of methodology and instrumentation for determination of chloroform in water

Creator:: Yang, Ying, 1969-
Resource Type:: Dissertation
Full Text:: the Determination of Chloroform in Water Abstract approved: James D. Ingle, Jr. Spectrophotometric

Formation of sulfenato and sulfinato cobalt (III) complexes by the oxidation of coordinated cysteine

Creator:: Sloan, Camilla Peel
Resource Type:: Masters Thesis
Full Text:: ACKNOWLEDGMENTS I would like to express my appreciation to Dr. James H. Krueger for his advice and continued

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