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  • A unified approach for the total synthesis of C₁₀-functionalyzed Lycopodium alkaloids

    Creator:
    Saha, Mrinmoy
    Abstract:
    Lycopodium alkaloids have shown widespread and noteworthy biological activity, consisting of over 250 known natural products. Moreover, their structural complexity and diversity have attracted considerable attention from numerous laboratories including our own. Recently, we have developed a unified approach that would provides access to numerous, previously unprepared C₁₀-functionalized lycopodium alkaloids....
    Resource Type:
    Dissertation
    Full Text:
    lycodine (1.2) NH N fawcettimine (1.3) phlegmarine (1.4) NH N N O OH H ! 4! Figure 1.2

  • Himeradine A : synthetic efforts towards himeradine A and related natural products, a Michael reaction focused approach

    Creator:
    Collett, Nathan D.
    Abstract:
    Lycopodium alkaloids have generated enormous amounts of interest from the scientific community, both as synthetic targets and for their medicinal properties. Herein is described work towards a unifying approach to large segments of the Lycopodium family. An organocatalyzed intramolecular heteroatom Michael reaction method, for the construction of piperidine and piperizine...
    Resource Type:
    Dissertation
    Full Text:
    ., Jr.; Sheehan, S. M. J. Org. Chem. 1997, 62, 78-87. 12 (a) Yang, H. Carter, R. G. Org. Lett. 2008

  • Enantioselective Total Syntheses of Quinolizidine Lycopodium Alkaloid Cermizine D and Cytotoxic Marine Macrolide Mandelalide A

    Creator:
    Veerasamy, Nagarathanam
    Abstract:
    The enantioselective total synthesis of quinolizidine-containing natural product cermizine D and formal syntheses of senepodine G and cermizine C has been achieved. These natural products are members of the lycopodium alkaloids, which have attracted significant attention due to their exciting biological activities and the diverse structural scaffolds. Key steps in...
    Resource Type:
    Dissertation
    Full Text:
    ) m-CPBA, 0 °C; Ph3PAuNTf2 (63%, 2 steps) dr > 50:1 N H O 1.2.1 1.2.2 1.2.3 1.2.4 9 5 5 4 4

  • Computational Investigation and Prediction of Mechanisms and Stereocontrol in Complex Organic Reactions

    Creator:
    Pattawong, Ommidala
    Abstract:
    Complex organic transformations, such as the addition of pyrrole to ketene using planar chiral organocatalyst (*PPY), the four-component anhydride- Manniach reactions, and the site-selective desymmetrization of meso-1,2-diol, are remarkable synthetic reactions that provide high yield and high selectivity. However, the exact mechanism and origins of stereocontrol for theses synthetic organic...
    Resource Type:
    Dissertation
    Full Text:
    . (c) Maier, N. M.; Franco, P.; Linder. W. J. Chromatogr., A. 2001, 906, 3. (d) Caner, H.; Groner, E

  • Optimizing the Membrane Architecture and Interrogating the Stability of Hybrid Lipid-coated Gold Nanoparticles for Biological Studies and Applications

    Creator:
    Kmetz-Gonzalez, Gemma
    Abstract:
    Nanoparticles are a hugely diverse category of material that have a wide variety of biomedical applications, and developing tools for biological research with high cellular uptake is critical to their effective application. However, rarely is attention paid to the exact mechanism by which this is occurring, with most studies focusing...
    Resource Type:
    Capstone Project
    Full Text:
    changes in O.D., with 1 h changes for samples of 1:4 PC:Chol, SOA, HT 3.21 ± 0.13%. For comparison

  • Novel ternary graphite intercalation compounds of alkali metal cations and amines

    Creator:
    Maluangont, Tosapol
    Abstract:
    Novel ternary graphite intercalation compounds (GICs) of alkali metal cations and a wide variety of amines have been synthesized by one-pot chemical syntheses. Alkali metals studied includes Li, Na and K. The families of amines employed are nalkylamines, branched alkylamines, and different structural isomers of diamines and polyamines. Intragallery structures...
    Resource Type:
    Dissertation
    Full Text:
    when appropriate. A homologous series of M-n-alkylamine-GICs (M = Na, Li) is reported for the

  • Graphite intercalation compounds containing tetra-n-alkylammonium cations

    Creator:
    Sirisaksoontorn, Weekit
    Abstract:
    Novel donor-type graphite intercalation compounds (GICs) containing tetra-n-alkylammonium (TAA) cations have been synthesized by using both ion-exchange and electrochemical methods. Structural and compositional data of the resulting TAA-GICs are investigated by using powder X-ray diffraction (PXRD), one-dimensional electron density calculations, thermogravimetric and elemental analyses, and capillary zone electrophoresis (CZE). A...
    Resource Type:
    Dissertation
    Full Text:
    ), (d) 0.1 M FeCl3 / 1 M HCl (aq) and (e) 0.01 M I2 / CHCl3. Reactions proceeded at 20°C for 24 h

  • Total Synthesis of Goniomitine : Development of Aminal and α-Amino Radicals in the Synthesis of Nitrogen-Rich Natural Products

    Creator:
    Vellucci, Jessica K.
    Abstract:
    Aminal radical intermediates were generated by the method of radical translocation and reacted in C-C bond forming reactions with electronically deficient alkenes (Schiedler et al. Org. Lett. 2012, 14, 6092). Aminal radical intermediates can participate in inter- and intra-molecular reactions using both Bu3SnH and (TMS)₃SiH as hydride donors. Carbon–carbon bonds...
    Resource Type:
    Dissertation
    Full Text:
    (e.g. alkyl–H). ! 4! Scheme 1.1 Hoffman–Löffler–Freytag reaction mechanism One of the

  • Exploratory Studies Within the Exotic Lyonsite Structure

    Creator:
    Tang, Joseph N.
    Abstract:
    Structure-property relationships have always underpinned the field of solid state chemistry; dependable structural descriptions are integral to understanding and controlling the physical properties of inorganic compounds old and new. While a handful of crystal structures are celebrated for their versatility, flexibility, and functionality, the existence of more exotic structures is...
    Resource Type:
    Dissertation
    Full Text:
    ). . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 203 B.3 Average degradation plot for MB over 2 h irradiation time. . . . . . . 204 B.4 Degradation

  • Displacement-based fluorescent microRNA biosensors : design principles and analytical metrics

    Creator:
    Larkey, Nicholas E.
    Abstract:
    One post-transcriptional mechanism that regulates the progression of cancer and other diseases involves small 22-23 nucleotide sequences called microRNA (miR). Early detection of small changes in concentration of these biomarkers holds potential to diagnose diseases at their earliest stages. Use of current nucleic-acid based biosensors, like molecular beacons, for in...
    Resource Type:
    Dissertation
    Full Text:
    . Chapter 4. Sean M. Burrows contributed in part to the preparation and review of this manuscript. Lulu