Index Catalog // ScholarsArchive@OSU

Pactamycin Inspired Drug Discovery: A Synthetic and Chemoenzymatic Approach

Creator:: Brumsted, Corey J.
Abstract:: Pactamycin, first reported in 1962, is a potent antitumor antibiotic produced by the soil bacterium Streptomyces pactum. Structurally, it contains a cyclopentitol core unit, a 3-aminoacetophenone (3AAP), a 6-methylsalicylic acid (6-MSA), and a N,N-dimethyl urea. The aminocyclopentitol ring is derived from glucose, possibly via N-acetyl glucosamine (GlcNAc), the 3-aminoacetophenone (3AAP)...
Resource Type:: Dissertation
Full Text:: like to thank Andrew Osborne and Edward Fynn for their friendship and support. I also want to thank

Hydrophobicity, Anion Exchange, and Phytoaccumulation of Per- and Polyfluoroalkyl Substances (PFAS): Retention and Remediation

Creator:: Parker, Bethany A.
Abstract:: Per- and polyfluoroalkyl substances (PFAS) are a group of contaminants of great concern due to their toxicity and ubiquity in the environment. Remediation efforts historically have focused on granular activated carbon (GAC) because of its low maintenance and relatively low cost. However, GAC is not PFAS selective and is especially...
Resource Type:: Dissertation
Full Text:: . Buck, R. C.; Franklin, J.; Berger, U.; Conder, J. M.; Cousins, I. T.; De Voogt, P.; Jensen, A

Development and Application of Mass Spectrometry-driven Methods for the Detection and Characterization of Biomolecular Signatures of Diseases

Creator:: Zandkarimi, Fereshteh
Abstract:: State-of-the-art, high-resolution mass spectrometry techniques for acquisition of metabolomic and lipidomic data coupled with advanced computational methods provide new opportunities for interpreting large and complex datasets and comprehending the underlying biological processes of diseases. Both metabolomics and lipidomics strive to obtain comprehensive analyses of small molecules, i.e., metabolites and lipids,...
Resource Type:: Dissertation

Part I: Total synthesis of marine macrolide amphidinolide F and synthetic studies toward amphidinolide C; Part II: Computational study on proline sulfonamide-catalyzed aldol reaction

Creator:: Mahapatra, Subham
Abstract:: More than 30 members of the diverse amphidinolide family of biologically active macrolides have been isolated over last three decades. From this family, amphidinolides C and F stand among the most complex and densely functionalized affiliates. Recently, we have accomplished the first total synthesis of amphidinolide F. The all-carbon framework...
Resource Type:: Dissertation
Full Text:: ,8 J,9 K,10 P,11 T,12 V,13 W,14 X,15 Y16 (Figure 1.1). Some of these works resulted in the

Synthesis of furanoeremophilane sesquiterpenoids

Creator:: Shanmugham, Meenakshi Sundaram
Abstract:: Two approaches to the tricyclic core of the furanoeremophilane sesquiterpenoids are described. The first approach entails a projected Diels-Alder/retro Diels-Alder reaction of an acetylenic oxazole 64. Construction of the pivotal aldehyde 67 commenced from ketone 68. The acetyenic moiety was then introduced via a Felkin-Ahn addition of lithiopropyne to aldehyde...
Resource Type:: Dissertation
Full Text:: , 16, 965. 4. Arciniegas, A.; Perez-Castorena, A. L.; Parada, G.; Villasenor, J. I.; De Vivar, R

Synthesis and Characterization of Alkylammonium Salts of Butyltin-Polyoxotungstates for Thin Film Functionalization

Creator:: Olsen, Morgan R.
Abstract:: Metal-oxo clusters are discrete, soluble pieces of bulk metal oxide. Cluster size, monodispersity, and chemical properties allow for potential use as solution-based precursors for functional metal oxide films. Classical monoalkyltin-oxo clusters are either charge neutral or stabilized by anions. The structure of Cs₄.₅H₂.₅[(BuSn)₃(α-SiW₉O₃₇)]*2H₂O enables its use in established ion exchange...
Resource Type:: Dissertation

Analytical Platform to Study Bacterial Metabolism and their Interactions with Biomaterials using SECM

Creator:: Sheet, Partha S.
Abstract:: The microbial communities play a crucial role in maintaining human health and cause diseases through very complex microbial chemical interactions. Therefore, these microbial communities have drawn much attention to the scientific communities. To elucidate these complex microbial communities and the chemical interactions within it, one or more isolated species of...
Resource Type:: Dissertation
Full Text:: ) Clemente, J. C.; Ursell, L. K.; Parfrey, L. W.; Knight, R. The Impact of the Gut Microbiota on Human

Determination of ethyl glucuronide and ethyl sulfate as human biomarkers of alcohol exposure in urine by liquid chromatography/electrospray tandem mass spectrometry with large volume injection

Creator:: Hu, Yan
Abstract:: This research was undertaken to develop a sensitive, selective, and rapid analytical method to measure ethyl glucuronide (EtG) and ethyl sulfate (EtS) in urine as urinary biomarkers of alcohol exposure. Large-volume injection (LVI) coupled with liquid chromatography / electrospray tandem mass spectrometry was used to eliminate the need for either...
Resource Type:: Masters Thesis

Trans-Pacific and regional atmospheric transport of anthropogenic semivolatile organic compounds in the western U.S.

Creator:: Primbs, Toby
Abstract:: The atmospheric transport of anthropogenic semivolatile organic compounds (SOCs) from Asian sources to the Western U.S. was investigated. In addition, the SOC extraction method was optimized. Hansen solubility parameter plots were used to aid in the pressurized liquid extraction (PLE) solvent selection of air sampling media in order to minimize...
Resource Type:: Dissertation
Full Text:: encouragement and support. The author wishes to dedicate his work in memory of his father Edward R.J. Primbs

The kinetic and radiolytic aspects of control of the redox speciation of neptunium in solutions of nitric acid

Creator:: Precek, Martin
Abstract:: Neptunium, with its rich redox chemistry, has a special position in the chemistry of actinides. With a decades-long history of development of aqueous separation methods for used nuclear fuel (UNF), management of neptunium remains an unresolved issue because of its not clearly defined redox speciation. Neptunium is present in two,...
Resource Type:: Dissertation
Full Text:: are directed at my collaborators and co-advisors Dr. Bruce J. Mincher from the Idaho National

ScholarsArchive@OSU

Pactamycin Inspired Drug Discovery: A Synthetic and Chemoenzymatic Approach

Hydrophobicity, Anion Exchange, and Phytoaccumulation of Per- and Polyfluoroalkyl Substances (PFAS): Retention and Remediation

Development and Application of Mass Spectrometry-driven Methods for the Detection and Characterization of Biomolecular Signatures of Diseases

Part I: Total synthesis of marine macrolide amphidinolide F and synthetic studies toward amphidinolide C; Part II: Computational study on proline sulfonamide-catalyzed aldol reaction

Synthesis of furanoeremophilane sesquiterpenoids

Synthesis and Characterization of Alkylammonium Salts of Butyltin-Polyoxotungstates for Thin Film Functionalization

Analytical Platform to Study Bacterial Metabolism and their Interactions with Biomaterials using SECM

Determination of ethyl glucuronide and ethyl sulfate as human biomarkers of alcohol exposure in urine by liquid chromatography/electrospray tandem mass spectrometry with large volume injection

Trans-Pacific and regional atmospheric transport of anthropogenic semivolatile organic compounds in the western U.S.

The kinetic and radiolytic aspects of control of the redox speciation of neptunium in solutions of nitric acid

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