Index Catalog // ScholarsArchive@OSU

Gene Activation Strategies in Filamentous Fungi for Natural Products Discovery

Creator:: Adpressa, Donovon A.
Abstract:: Fungi have long been a prolific source of clinically approved drugs. The antibiotic penicillin, the cholesterol lowering statins, and the immunosuppressant cyclosporine have changed the treatment of human diseases in the last century. Recently, genome analysis of filamentous fungi has revealed that the biosynthetic potential for natural product expression is...
Resource Type:: Dissertation
Full Text:: polyketides (allianthrones A-C). In each instance presented, application of a gene activation technique

Solid-phase synthesis and biophysical testing of uncharged acyclic oligonucleotide analogues

Creator:: Nelson, Jeffrey Stephen, 1962-
Resource Type:: Dissertation
Full Text:: Synthesis and Biophysical Testing of Uncharged Acyclic Oligonucleotide Analogues. by Jeffrey S. Nelson A

The vibrational spectrum of polyoxymethylene

Creator:: Snyder, Robert Gene
Resource Type:: Dissertation
Full Text:: VIBRATIONAL SPECTRUM OF P OLYOXYMETHYLENE by ROBERT GENE SNYDER A THESIS submitted to OREGON STATE

Gene Expression, Structure Elucidation, and Bioactivity of Aspergillus Natural Products

Creator:: Neuhaus, George F.
Abstract:: The study of natural products (NPs) and their application has shaped humanity. Starting with the idea of using plants as medicine, it has now grown into the science of purifying and identifying organic molecules from nature to study their inherent biological activities. Understanding the molecular structures of NPs is the...
Resource Type:: Dissertation
Full Text:: genetic information as a road map, many silent or cryptic gene clusters have been targeted with an array

The infrared spectrum of porphin

Creator:: Nelson, Harry Martin
Resource Type:: Dissertation
Full Text:: SPECTRUM OF .PORPHIN by BARRY MARTIN NELSON . A THESIS submitted to OREGON STATE COLLEGE ln

Capturing Molecular Movies of Organic and Organometallic Systems in Solution by Ultrafast Spectroscopy

Creator:: Boulanger, Sean A.
Abstract:: Ultrafast spectroscopy can exploit the structure-function relationship of chemical- and biological-based systems. More specifically, femtosecond stimulated Raman spectroscopy (FSRS) provides ground- and excited-state vibrational information with simultaneously high spectral (spatial) and temporal resolutions. The electronic counterpart, femtosecond transient absorption (fs-TA), complements FSRS data analysis as part of a comprehensive approach...
Resource Type:: Dissertation
Full Text:: ), complements FSRS data analysis as part of a comprehensive approach to capture fundamental processes and

Displacement-based fluorescent microRNA biosensors : design principles and analytical metrics

Creator:: Larkey, Nicholas E.
Abstract:: One post-transcriptional mechanism that regulates the progression of cancer and other diseases involves small 22-23 nucleotide sequences called microRNA (miR). Early detection of small changes in concentration of these biomarkers holds potential to diagnose diseases at their earliest stages. Use of current nucleic-acid based biosensors, like molecular beacons, for in...
Resource Type:: Dissertation
Full Text:: , this work describes a new miR biosensor that was created to improve upon existing miR biosensors and

Development of novel analytical methods to detect emerging contaminants in aqueous environmental matrices using large-volume injection

Creator:: Backe, Will J.
Abstract:: It is the responsibility of humans, as environmental stewards, to monitor our impact on the environment so that efforts can be made to remediate the effects of our actions and change behaviors. To better understand our environmental footprint, sensitive and simple analytical methods are needed to quantify the contaminants that...
Resource Type:: Dissertation
Full Text:: : _____________________________________________________ Jennifer A. Field It is the responsibility of humans, as environmental stewards, to monitor

Per- and Polyfluoroalkyl Substances (PFASs) and Aqueous Film-Forming Foam Impacted Sites : New PFAS Discovery and Sorption of Anionic, Zwitterionic, and Cationic PFASs

Creator:: Barzen-Hanson, Krista A.
Abstract:: Public attention and concern about per- and polyfluoroalkyl substances (PFASs) are increasing due to detection of PFASs in drinking water supplies, the environment, including remote locations, and wildlife and to the lowering of the federal health advisory levels of perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) in drinking water. Aqueous film-forming...
Resource Type:: Dissertation
Full Text:: Krista A. Barzen-Hanson for the degree of Doctor of Philosophy in Chemistry presented on January 10

Metabolism of pyrrolizidine alkaloids by ruminal microbes

Creator:: Hovermale, Jeannette Talbot
Abstract:: The plant Senecio jacobaea (tansy ragwort) produces several macrocyclic pyrrolizidine alkaloids which cause irreversible liver cirrhosis. All of the pyrrolizidine alkaloids in Senecio jacobaea are macrocyclic diesters of the necine base retronecine, with the two most predominant being seneciphylline and jacobine. Unlike horses and cattle, sheep and goats are generally...
Resource Type:: Dissertation
Full Text:: . Abstract approvecRedacted for Privacy A. Morrie Craig The plant Senecio jacobaea (tansy ragwort) produces

ScholarsArchive@OSU

Gene Activation Strategies in Filamentous Fungi for Natural Products Discovery

Solid-phase synthesis and biophysical testing of uncharged acyclic oligonucleotide analogues

The vibrational spectrum of polyoxymethylene

Gene Expression, Structure Elucidation, and Bioactivity of Aspergillus Natural Products

The infrared spectrum of porphin

Capturing Molecular Movies of Organic and Organometallic Systems in Solution by Ultrafast Spectroscopy

Displacement-based fluorescent microRNA biosensors : design principles and analytical metrics

Development of novel analytical methods to detect emerging contaminants in aqueous environmental matrices using large-volume injection

Per- and Polyfluoroalkyl Substances (PFASs) and Aqueous Film-Forming Foam Impacted Sites : New PFAS Discovery and Sorption of Anionic, Zwitterionic, and Cationic PFASs

Metabolism of pyrrolizidine alkaloids by ruminal microbes

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