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Filtering by: Creator Lee, Tong-Yee Degree Field Chemistry Subject Lipids -- Peroxidation

Tandem mass spectrometric analysis of protein and peptide adducts of lipid peroxidation-derived aldehydes

Creator:

Wu, Jianyong

Abstract:

The adduction of proteins and other biomolecules by electrophilic lipid peroxidation products such as 4-hydroxy-2-nonenal (HNE), 4-oxo-2-nonenal (ONE), malondialdehyde (MDA) or acrolein (ACR) is thought to be an initiating and/or propagating factor in the pathophysiology of several diseases such as atherosclerosis, diabetes, Alzheimer's, Parkinson's and other age-related disorders. The identification...

Resource Type:

Dissertation

Full Text:

. Mooney, G. Clark-Scannell, T.T. Tong, J. Watson, T.M. Hagen, J.F. Stevens, C.S. Maier, J. Proteome Res
Mass spectrometry-based identification and characterization of protein and peptide adducts of lipoxidation-derived aldehydes

Creator:

Chavez, Juan D.

Abstract:

Oxidative stress is recognized as an important underlying factor in the pathogenesis of many degenerative diseases as well as normal senescence. The free radicals, reactive oxygen species (ROS) and electrophiles produced during oxidative stress are capable of modifying nucleic acids, lipids and proteins. There are a variety of oxidative modifications...

Resource Type:

Dissertation