Index Catalog // ScholarsArchive@OSU

Total synthesis of sparteine alkaloids from a common tetraoxobispidine intermediate

Creator:: Melbardis, John
Abstract:: In previous work (Blakemore et al. Org. Lett. 2005, 7, 4721; Heterocycles 2006, 70, 609), successful elaborations of the lupine alkaloids (±)-α-isosparteine (dl-2) and (±)-β-isosparteine (dl-3) were realized from a common tetraoxobispidine precursor, 3,7-diallyl -2,4,6,8-tetraoxo-3,7-diazabicyclo[3.3.1]nonane (93). Herein, the tetraoxobispidine approach to lupine alkaloids was extended to a total synthesis of...
Resource Type:: Masters Thesis
Full Text:: AN ABSTRACT OF THE THESIS OF John Melbardis for the degree of Master of Science in

Atropisomeric 8,8'-biquinolyl derivatives : synthesis, properties and applications

Creator:: Milicevic, Selena D.
Abstract:: 7,7'-Dihydroxy-8,8'-biquinolyl (azaBINOL) was prepared from 7-hydroxyquinoline via N,N-dimethyl O-quinol-7-yl carbamate by directed ortho-metallation followed by FeCl₃-mediated oxidative coupling of the 8-lithioquinoline intermediate. Saponification of the resulting dicarbamate provided crystalline (±)-azaBINOL in 56% overall yield. 6,6'-Bis(dimethylaminocarbonyl)-7,7'-dihydroxy-8,8´-biquinolyl was prepared from the same dicarbamate by a double anionic-Fries rearrangement in 43% yield. 7,7'-Bis(diethylamino-carbonyloxy)-6,6'-diiodo-8,8´-biquinolyl...
Resource Type:: Dissertation
Full Text:: Paul R. Blakemore 7,7´-Dihydroxy-8,8´-biquinolyl (azaBINOL) was prepared from 7-hydroxyquinoline

Insights and Patterns from Quantitative and Statistical Analyses of Chemical Systems

Creator:: Grove, Markas Albert
Abstract:: The work presented here is the culmination of efforts in describing complex chemical systems with statistical methods, thereby providing relatively simple quantitative models and easily comprehensible qualitative insights. The following investigations have various goals, such as development of new methods, fundamental understanding, molecular control of chemical species, and advancement of...
Resource Type:: Dissertation
Full Text:: Abstract approved: ______________________________________________________ Paul Ha-Yeon Cheong

Computational Investigations of Transition Metal Catalyses and Amorphous Metal Oxides : Accelerating Scientific Discovery Through Automation

Creator:: Mustard, Thomas J. L.
Abstract:: Automation of computational chemistry, while only an engineering feat, has the potential to accelerating computational research be removing all by the science. The work in this thesis mainly discusses fundamental understanding of complex chemical systems. What is not obvious are the numerous tasks necessary for this fundamental understanding. Under the...
Resource Type:: Dissertation
Full Text:: : ______________________________________________________ Paul Ha-Yeon Cheong Automation of computational chemistry, while only an engineering

Growth and characterization of wide–gap semiconducting oxide and chalcogenide thin films by pulsed laser deposition

Creator:: Newhouse, Paul F.
Abstract:: The preparation and characterization of thin film oxides and chalcogenides by pulsed laser deposition (PLD) is presented. An overview of fundamental PLD concepts are presented and are followed by a description implementation and development of the PLD systems at OSU. We present the results of thin film growth of high...
Resource Type:: Dissertation
Full Text:: AN ABSTRACT OF THE DISSERTATION OF Paul F. Newhouse for the

Rationalization and innovative design of asymmetric organocatalysts through computational investigation

Creator:: Johnston, Ryne Connell
Abstract:: My work on computing complex catalyzed organic transformations reveals that only a few subtle chemical factors, e.g. non-classical hydrogen bonding, (hyper)conjugation and steric effects, common across different catalyst manifolds are critical for catalysis and selectivity. Rational manipulation and exploitation of these factors has led to improved catalyst designs, which has...
Resource Type:: Dissertation
Full Text:: Organocatalysts through Computational Investigation. Abstract approved: Paul Ha-Yeon Cheong

The relationship of 5'-nucleotidase activity in lamb muscle tissue to sub-minimal selenium levels administered to their dams

Creator:: Arnold, Margaret Anna
Abstract:: White muscle disease or muscular dystrophy of sheep is a selenium responsive malady common to many areas with an inherent natural deficiency of selenium in the forage. The disease can be prevented in lambs by adding trace amounts (approximately 0.1 ppm) of selenium to the otherwise selenium deficient, forage fed...
Resource Type:: Masters Thesis
Full Text:: Bratltude for the encouragement and help of her maJor professorl Dr. Paul H. !{eswtg and hls predeces- sorr

Using Computational and Statistical Methods as an Aid to Study Environmentally Relevant Organic Molecules

Creator:: Dorn, Shelby E.
Abstract:: In this report, three studies are presented that utilize computations to predict transformations, identities, and properties of environmental organic molecules. Each study shows how computations can lead to models of chemical behavior. The importance of this research is rooted in the need for understanding how human behavior and health intersect...
Resource Type:: Masters Thesis
Full Text:: Molecules. Abstract approved: ______________________________________________________ Paul Ha

Nutritional muscular dystrophy production and pectoral muscle 5'-nucleotidase activity in the chick

Creator:: Roffler, Sheila Ann
Abstract:: In an attempt to find a laboratory species which develops an experimental myopathy similar to white muscle disease (WMD) in lambs, comparative studies of nutritional muscular dystrophy of chicks were initiated. This condition was grossly visible as white striations running parallel with the fibers of the pectoral muscles and was...
Resource Type:: Masters Thesis
Full Text:: major professor, Dr. Paul H. Weswig, during these studies. Special thanks are also due Dr. John R

Expediting the Generation and Analysis of Amorphous Oxide Computational Models: Modeling Complex Systems Swiftly

Creator:: Buchanan, Jacob C.
Abstract:: In this dissertation, the process of computational modeling of amorphous oxide materials is studied. Amorphous oxides have random atomic arrangements with no long-range structural order which makes it difficult to study structure-property relationships. Despite the difficulties, amorphous oxides have great uses as semiconductors and dielectrics in thin-film transistors. The ability...
Resource Type:: Dissertation
Full Text:: : ___________________________________________________ Paul Ha-Yeon Cheong In this dissertation, the process of computational modeling of

ScholarsArchive@OSU

Total synthesis of sparteine alkaloids from a common tetraoxobispidine intermediate

Atropisomeric 8,8'-biquinolyl derivatives : synthesis, properties and applications

Insights and Patterns from Quantitative and Statistical Analyses of Chemical Systems

Computational Investigations of Transition Metal Catalyses and Amorphous Metal Oxides : Accelerating Scientific Discovery Through Automation

Growth and characterization of wide–gap semiconducting oxide and chalcogenide thin films by pulsed laser deposition

Rationalization and innovative design of asymmetric organocatalysts through computational investigation

The relationship of 5'-nucleotidase activity in lamb muscle tissue to sub-minimal selenium levels administered to their dams

Using Computational and Statistical Methods as an Aid to Study Environmentally Relevant Organic Molecules

Nutritional muscular dystrophy production and pectoral muscle 5'-nucleotidase activity in the chick

Expediting the Generation and Analysis of Amorphous Oxide Computational Models: Modeling Complex Systems Swiftly

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