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Filtering by: Creator Pfleeger, Thomas G. Remove constraint Creator: Pfleeger, Thomas G. Degree Field Chemistry Remove constraint Degree Field: Chemistry

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  • Studies towards the total syntheses of (+)-phomactins A, D and G

    Creator:
    Schwartz, Keith D.
    Abstract:
    Studies towards the total synthesis of (+)-Phomactin A (1), D (6), and G (9), fungal metabolites with unique molecular architecture and pronounced biological activity, are described. These studies resulted in the synthesis of advanced intermediates 354 and 356, which contain all of the carbon atoms of 1, 6 and 9....
    Resource Type:
    Dissertation
    Full Text:
    September 23, 2009. Title: Studies Towards the Total Syntheses of (+)-Phomactins A, D and G. Abstract

  • A comparative study of the in vitro localization of mercury from phenylmercuric acetate and mercuric salt in rat kidney and liver subcellular fractions and their effect on alkaline phosphatase

    Creator:
    Massey, Thomas H.
    Abstract:
    Studies were undertaken to determine the extent and rate of binding of Hg-203 labeled phenylmercuric acetate and mercuric ace tate in rat kidney and liver slices and their subcellular fractions after 37°C incubation of the slices in Krebs-Ringer -phosphate solutions containing the mercurials at 10⁻⁴ molar. A fast and parallel...
    Resource Type:
    Masters Thesis
    Full Text:
    their effect on alkaline phosphatase AN ABSTRACT OF THE THESIS OF Thomas Harding Massey for the M. S

  • Reactions of organoboranes

    Creator:
    Thompson, Thomas Myron
    Abstract:
    An examination was made of some reactions involving a transfer of carbon from boron to carbon. In the case of the reaction of a C[subscript n] alkylorganoborane with dichlorocarbene the intermediate was a C[subscript n]₊₁ chloroalkylorganoborane. Oxidation of this intermediate yielded an homologous acid (33%) and the usual alcohol (66%)....
    Resource Type:
    Masters Thesis
    Full Text:
    Thomas Myron Thompson for the M. S. in Chemistry (Organic) (Name) (Degree) (Major) Date thesis is

  • Steroid dialkylcarbene reactions

    Creator:
    Dixon, Dale David
    Abstract:
    Steroid carbenes have been investigated as synthetic intermediates. Basic decomposition of 4-en-3-one tosylhydrazones (and other A-ring systems) gives varying amounts of 2, 4-dienes, and solvent derived products with diglyme, heptane, tetrachloroethylene, carbon tetrachloride, benzene and cyclohexene. A method for separating complex product mixtures was developed and a study of the...
    Resource Type:
    Dissertation
    Full Text:
    express my appreciation to Dr. F. Thomas Bond for his instruction, encouragement, and scientific

  • Steroid-dihalocarbene reactions

    Creator:
    Damewood, John Roderick
    Abstract:
    Dihalocarbenes have been generated by thermal decomposition of sodium trichloroacetate and tribromomethylphenylmercury, and give mono dihalocyclopropyl adducts with steroid dienes. Such compounds offer an easy starting point for the synthesis of unusual derivatives of potential biological interest. Under the same conditions, however, addition to non-conjugated double bonds does not take...
    Resource Type:
    Masters Thesis
    Full Text:
    Dr. F. Thomas Bond for his guidance and assistance in the preparation of this thesis. TABLE OF

  • Chemistry of cyclobutane compounds

    Creator:
    Musa, Willie Edsel
    Abstract:
    Examination of a proposed reaction scheme to prepare bicyclo-(2.2.0)hexan-1-ol produced the first known condensation of an enamine with its carbonyl precursor. Hydrolysis of the resulting dienamine gave an unusual conjugated cyclobutenone in which the double bond is exocyclic. Characterization and reactions of the cyclobutenone were successfully carried out.
    Resource Type:
    Masters Thesis
    Full Text:
    (ltr5 ACKNOWLEDGEMENT The author wishes to express his appreciation to Dr. F.. Thomas Bond for his

  • Dihalocarbene reactions with steroid olefins

    Creator:
    Cornelia, Richard Hartman
    Abstract:
    Dihalocarbenes have been generated mainly by thermal decomposition of sodium trihaloacetate and phenyl (trihalomethyl)mercury, and give gem-dihalocyclopropyl adducts with various steroid olefins. A new procedure involving the use of sealed tubes makes possible the addition of dihalocarbenes to sterically hindered olefins. In this manner, 7-cholestenyl benzoate when treated with PhHgCC1₃...
    Resource Type:
    Dissertation
    Full Text:
    . Thomas Bond for his critical reading of the manuscript. TABLE OF CONTENTS INTRODUCTION 1

  • Steroid organoborane reactions

    Creator:
    Byall, Elliott Bruce
    Abstract:
    Steroid organoboranes have been found to be useful synthetic intermediates. Attempted pyrolyses, based on simple trialkylborane cyclizations, have not yielded C-19 or C-18 functionalized steroids, but have produced isomerized systems not otherwise available. Thus, hydroboration of cholesterol followed by pyrolysis at 215° gives 31% of 2-cholestene-6α-ol and 49% of a...
    Resource Type:
    Dissertation
    Full Text:
    . Thomas Bond Steroid organoboranes have been found to be useful synthetic intermediates. Attempted

  • Some synthetic efforts in small ring chemistry

    Creator:
    Lam, Luke Kwok Tung
    Abstract:
    Cyclopropylcyclobutene was prepared via the intermediate dicyclopropylcarbinyl carbene which was generated by the thermal decomposition of the sodium salt of dicyclopropylketone p-toluenesulfonylhydrazone. The successive thermal isomerization of cyclopropylcyclobutene to 2-cyclopropyl-1, 3-butadiene and to vinylcyclopentene was studied. Kinetic data were obtained for the cyclopropylcyclobutene to 2-cyclopropyl-1, 3-butadiene isomerization in the gas...
    Resource Type:
    Masters Thesis
    Full Text:
    . Thomas Bond Cyclopropylcyclobutene was prepared via the intermediate dicyclopropylcarbinyl carbene

  • Conformation and reactivity studies of some bicyclo(3.3.1) nonane derivatives

    Creator:
    Sturmer, David Michael
    Abstract:
    New syntheses for 2-bicyclo(3.3.1)nonanone and 7-bicyclo-(3.3.1)nonen-2-one were developed. The saturated ketone was prepared from phenol and acrylonitrile via a novel intramolecular S[subscript N]2 cyclization process. A Friedel-Crafts cyclization of 3-(3-cyclohexenyl)propanoyl chloride permitted synthesis of the unsaturated ketone from 4-cyclohexene carboxaldehyde. The formation of the bicyclo(3.3.1)nonane rather than a bicyclo(3.2.2)nonane skeleton...
    Resource Type:
    Dissertation
    Full Text:
    20 g,7HL C) O 25 functional groups. Their discussion of the spectral characteristics of