Index Catalog // ScholarsArchive@OSU

Synthesis and Solution Characterization of Metal-Oxo Photoresist Precursors

Creator:: Hutchison, Danielle C.
Abstract:: Metal-oxo clusters can be described as soluble pieces of metal-oxide frameworks. Currently, metal-oxo clusters are being considered as solution-based precursors for extreme ultraviolet (EUV, 13.5 nm) photoresist materials, which are a crucial component in the fabrication of microelectronic devices. Two different photoresist precursor systems have been investigated – alkyltin clusters...
Resource Type:: Dissertation
Full Text:: DISSERTATION OF Danielle C. Hutchison for the degree of Doctor of Philosophy in Chemistry presented on

Synthetic studies on marine natural products : I. Stereoselective synthesis of E,Z-1,3-Dienes by tandem nucleophilic addition to a dienylphosphonium salt followed by Wittig reaction. II. Synthesis of cyclopropyl oxylipins by a cation mediated carbocyclization

Creator:: Jensen, Mark S.
Resource Type:: Dissertation
Full Text:: approved: James D. White I. A new stereoselective route for the synthesis of E,Z-1,3-dienes using a

The nature of the chemical constituents of incense cedar, Libocedrus decurrens (Torr.) bark

Creator:: Smith, James E. (James Edward)
Abstract:: The purpose of this investigation was to determine the nature of the chemical constituents of incense cedar bark with the hope that such an endeavor would spur future research, development and use of a now neglected natural raw material. The bark from nine trees, which were separated into three age...
Resource Type:: Masters Thesis
Full Text:: , (Libocedrus Decurrens Torr.) Bark AN ABSTRACT OF THE THESIS OF James Edward Smith for the U.S. in

The chemical nature of the "lignin" of the bark of Douglas fir, Pseudotsuga menziesii (Mirb.) Franco

Creator:: Smith, James E. (James Edward)
Resource Type:: Dissertation
Full Text:: DOUGLAS FIR, · PSEUDOTSUGA MENZIESII (MffiB.) FRANCO by JAMES EDWARD ITH A THESIS submitted to

Polarization spectroscopy and photodissociation studies of nitroaromatic compounds in the gas phase

Creator:: Abbott, James E.
Abstract:: The central purpose of this dissertation was to explore and expand the use of an uniform electric field for orientation and for subsequent spectroscopic investigation of asymmetric polar molecules in the gas phase. The systems of study were nitrobenzene (NB) and the nitrotoluene (NT) isomers. We were able to quantitatively...
Resource Type:: Dissertation
Full Text:: DISSERTATION OF James E. Abbott, Jr. for the degree of Doctor of Philosophy in Chemistry presented on

Higher valence compounds of iron

Creator:: Schreyer, James Marlin
Resource Type:: Dissertation
Full Text:: OF IRON JAMES MARLIN SCIIREER A THESIS submitted to OREGON STATE COLLEGE in partial

The distribution and properties of the tannin in Douglas fir bark (Pseudotsuga taxifolia, Britt.)

Creator:: Hubbard, James Kenneth
Resource Type:: Masters Thesis
Full Text:: the condenser "D." The stopcock "E" is used to direct the flow of the percolate from "A.' Figure

A study of the iodine-formate reaction in dimethylsulfoxide-water mixtures

Creator:: Hiller, Frederick Wayne
Resource Type:: Dissertation
Full Text:: , I3 + HCOO -.CO2 + 3I + H +. The rate law, rate = k[ E I2] [ HCOO ] [ I ] - 1, is observed in all

Synthesis of marine natural products. part I, Cryptophycins-1, -3, -4, -24, and -29, part II, Polycavernoside A

Creator:: Robarge, Lonnie A.
Resource Type:: Dissertation
Full Text:: A. Abstract approved:, James D. White Part 1: A convergent synthesis of cryptophycins has been

Solubilization of acid nonextractable flavin-linked protein by cyanide

Creator:: Wu, James Tsai Yuan
Abstract:: It has been reported that cyanide inactivates the succinate dehydrogenase activity of HMP toward cytochrome c, oxygen, methylene blue and DCIP. In the present study, it was found that cyanide also solubilizes the SDH from HMP, this is reflected by the extent of solubilization of acid nonextractable flavin in the...
Resource Type:: Masters Thesis
Full Text:: AN ABSTRACT OF THE THESIS OF James Tsai Yuan Wu (Name of

Approaches to the total synthesis of verrucarol

Creator:: Hill, David E. (David Edwin) 1954-
Abstract:: Verrucarol is the sesquiterpene portion of a number of macrocyclic di- and triesters of potential medicinal importance. In this study, a novel approach to the synthesis of this fungal metabolite is presented. An A-B-C route was investigated in which C-3 and C-4 of the C-ring were emplaced using a [2+2]...
Resource Type:: Dissertation
Full Text:: ABSTRACT OF THE THESIS OF David E. Hill for the degree of Doctor of_Philosophy in Chemistry presented on

Studies towards the total synthesis of (-)-kendomycin

Creator:: Smits, Helmars
Abstract:: Studies towards the total synthesis of (−)-kendomycin (1), a bacterial metabolite with a unique molecular architecture and pronounced biological activity, are described. These studies resulted in the synthesis of advanced intermediate 208, containing all of the carbon atoms of 1. A Dötz annulation between alkyne 122 and novel chromium carbenoid...
Resource Type:: Dissertation
Full Text:: :_____________________________________________________ James D. White Studies towards the total synthesis of (−)-kendomycin (1), a bacterial

Synthesis and oligomerization of y,4-Diamino-2-oxo-1(2H)-pyrimidinepentanoic acid

Creator:: Nelson, Jeffrey Stephen
Abstract:: Described herein is the synthesis of an uncharged stereoregular oligonucleotide analog consisting of cytosine bases linked at specific intervals to a polyamide backbone derived from (L)-glutamic acid. Preparation of this analog entailed borane reduction of (L)- pyroglutamic acid to give optically pure lactam alcohol 9. Tosylation and alkylation with cytosine...
Resource Type:: Masters Thesis
Full Text:: K. Mathews, James H. Krueger, and James E. Lannan for serving as members of my graduate committee

Part I: Synthesis and evaluation of synosutine as an inhibitor of serotonin, norepinephrine, and dopamine transporters Part II: Asymmetric approach to the tetracyclic core of neomangicol A

Creator:: Juniku, Rajan B.
Abstract:: Part I: Racemic and asymmetric syntheses of a new substance with prospective antidepressant properties were achieved. In vitro assays with synthetic racemates (±)-25 and (±)-26 suggested that the former is a relatively selective inhibitor of serotonin transporter whereas the latter is a more balanced inhibitor of both serotonin and norepinephrine...
Resource Type:: Dissertation
Full Text:: Abstract approved: _____________________________________________________ James D. White Part I

Absolute stereochemistry and total synthesis of botryococcene

Creator:: Reddy, Guvvala Nagabhushana
Abstract:: Studies were carried out to determine the absolute stereochemistry of botryococcene (1). The natural product was degraded to two sets of 'y- and 8- valerolactones. All enantiomeric variations of these lactones were synthesized in optically pure form starting from (S)- and (R)-methyloxiranes. 1H NMR correlation of natural and synthetic materials...
Resource Type:: Dissertation
Full Text:: Botryococcene Abstract approved: Pedacted for Privacy Li James D. White Studies were carried out to determine

Studies toward the synthesis of halichlorine and pinnaic acid

Creator:: Korf, Eric A.
Abstract:: Three approaches toward the core of halichlorine and pinnaic acid are described. The first approach entails a racemic transannular nitrone-olefin [3+2] cycloaddition from nitrone 238. Construction of the nitrone 238 began with aldehyde 241. Another key feature in this route involved a ring-closing metathesis for the formation of a 14-membered...
Resource Type:: Dissertation
Full Text:: approved: James D. White Three approaches toward the core of halichlorine and

Studies towards the total syntheses of (+)-phomactins A, D and G

Creator:: Schwartz, Keith D.
Abstract:: Studies towards the total synthesis of (+)-Phomactin A (1), D (6), and G (9), fungal metabolites with unique molecular architecture and pronounced biological activity, are described. These studies resulted in the synthesis of advanced intermediates 354 and 356, which contain all of the carbon atoms of 1, 6 and 9....
Resource Type:: Dissertation
Full Text:: James D. White Studies towards the total synthesis of (+)-Phomactin A (1), D (6), and G (9), fungal

Mass spectrometric analysis of UV-crosslinked protein-nucleic acid complexes

Creator:: Doneanu, Catalin E.
Abstract:: The DNA-binding domains of E. coli uracil-DNA glycosylase (Ung) and human replication protein A (hRPA) were studied using a general protocol developed in our laboratory for probing protein-DNA interactions. The procedure involves purification and mass spectrometric analysis of the nucleopeptide-products of a tryptically digested UV-crosslinked protein-nucleic acid complex. In the...
Resource Type:: Dissertation
Full Text:: AN ABSTRACT OF THE DISSERTATION OF Catalin E. Doneanu for the

Chiral synthesis of monic acid C

Creator:: Theramongkol, Parinya
Abstract:: Bromoalkoxylation of dihydropyran with bromine and 1-borneol, followed by dehydrobromination and epoxidation, afforded trans-2-1- bornyloxy-3,4-epoxytetrahydropyran as a major product. This was treated with sodium phenylselenide to give a 1:1 mixture of (2R,3R,4R)- 2-1-bornyloxy-3-hydroxy-4-phenylselenotetrahydropyran and its (2S,3S, 4S) diastereomer. Elimination of the selenoxide, derived from oxidation of the former with hydrogen...
Resource Type:: Dissertation
Full Text:: ,,, James D. White Bromoalkoxylation of dihydropyran with bromine and 1-borneol, followed by

Synthesis and oxidation of metal-thiolate compounds which mimic the active site function of thiolate dioxygenase enzymes

Creator:: Schussel, Leonard J.
Abstract:: Part I describes the synthesis of bis(fac-S)((tris)2-aminoethanethiolatoiron( III))iron(III) chloride. The compound was first discovered during an attempt to prepare a ternary complex of iron, thiolate and pi-acid ligand. The compound is a reasonably air-stable iron(III)-thiolate that contains a linear tri-iron cluster with each iron bridged to the adjacent iron by...
Resource Type:: Dissertation
Full Text:: DIOXYGENASE ENZYMES Abstract approved: Redacted for Privacy Dr. James H. Krueger Part I describes the

Approaches to the synthesis of the macrolactone pyrrolizidine alkaloids (-)-integerrimine and (+)-usaramine

Creator:: Jayasinghe, Lalith Ratnasiri
Abstract:: A formal total synthesis of the macrolactone pyrolizidine alkaloid (-)-integerrimine (2), from R-(+)-citronellal (93) is described. Aldehyde 93 was converted to exo methylene derivative 94 which was reduced to allylic alcohol 95. The epoxides 96 and 98, obtained in a ratio of 3:1 respectively by Sharp less epoxidation of 95...
Resource Type:: Dissertation
Full Text:: . Redacted for privacy Abstract approved: James D. White A formal total synthesis of the macrolactone

Cis-2,5-diaminobicyclo[2.2.2]octane : a novel C₂-symmetric scaffold for asymmetric catalysis

Creator:: Shaw, Subrata
Abstract:: This thesis describes the development of a new enantioselective synthetic method employing chiral cis-2,5-diaminobicyclo[2.2.2]octane-based organometallic catalysts. The significance of this new method to organic synthesis is illustrated with preparation of enantioenriched products that are transformed to important pharmaceutical agents. Chapter 1 provides a brief historical overview of asymmetric catalysis, especially...
Resource Type:: Dissertation
Full Text:: [2.2.2]octane: A Novel C2-Symmetric Scaffold for Asymmetric Catalysis Abstract approved: James D

Synthetic approaches to the tricarbonyl subunit of rapamycin

Creator:: LaMunyon, James B.
Abstract:: Rapamycin (5) was isolated in 1975 from the soil bacteria Streptomyces hygroscopicus and its structure was determined from spectroscopic techniques and an x-ray crystallographic analysis. Although it was initially found to exhibit antibiotic activity, it was subsequently shown to possess potent immunosuppressive activity as well. Three approaches to the synthesis...
Resource Type:: Masters Thesis
Full Text:: AN ABSTRACT OF THE THESIS OF James B. LaMunyon for the degree

Approaches to the synthesis of trichothecane sesquiterpenes

Creator:: Thomas, James Anthony
Resource Type:: Dissertation
Full Text:: sesquiterpenes AN ABSTRACT OF THE THESIS OF James Anthony Thomas for the degree of Doctor of Philosophy in

The rotational motion of molecules in crystalline solids

Creator:: Miller, R. E.
Abstract:: Theoretical studies and experimental results are presented for the rotational motion of molecule's in crystalline solids. The group theory is solved for molecules of any symmetry matrix isolated at a site in a crystal field of any symmetry. As the potential terrier to rotation of the molecule relative to the...
Resource Type:: Dissertation
Full Text:: support to the evidence for rotation and the James-Keenan model for the lowest temperature phase of neat

Total synthesis of phorboxazole A

Creator:: Lee, Tae Hee
Abstract:: The total synthesis of a highly potent cytotoxic marine natural product, phorboxazole A, is described. Both a palladium(II)-mediated and a palladium(II)-catalyzed intramolecular alkoxycarbonylation were used as key steps for the preparation of the two cis-2,6-disubstituted tetrahydropyran rings (C22-C26 and C11-C15) of phorboxazole A. The synthesis used a convergent approach involving...
Resource Type:: Dissertation
Full Text:: : James D. White The total synthesis of a highly potent cytotoxic marine natural product

Characterization and applications of polyphenol chemiluminescence reactions and flow cell instrumentation

Creator:: Miller, Robert J. (Robert James), 1933-
Resource Type:: Dissertation
Full Text:: chemiluminescence reactions and flow cell instrumentation AN ABSTRACT OF THE THESIS OF Robert James Miller for

Design and application of a microcomputer automated multielement flame atomic fluorescence instrument

Creator:: Neyzari, Shahrokh Ghaffari
Abstract:: An automated multielement flame atomic fluorescence (AF) spectrometer based on microcomputer control was constructed to determine four elements simultaneously. The instrument employs a multiple exit slit monochromator where the light from various exit slits is directed to a single detector with a mirrored funnel. Each element is excited to fluoresce...
Resource Type:: Dissertation
Full Text:: (Ghaemi) Ghaffari Whom I (X)' the most, With special thanks to Dr. James D. Ingle, my thesis advisor

The formation of radioactive lysine and histidine from CH₃C¹⁴OOH and CH₃C¹⁴O COOH in yeast

Creator:: Davis, James Wendell
Resource Type:: Masters Thesis
Full Text:: CHC1OOH AND CH3C3-O COOl! IN lEAST by JAMES 1NDELL DAVIS A THESIS submitted to OREGON STATE

Polymeric submicron optical ion-selective sensors

Creator:: Bychkova, Valeriya
Abstract:: Ion-selective polymeric optical sensors – ion optodes – are a promising alternative to ion-selective electrodes and fluorescent dyes for analytical and biological applications, e.g. extra- and intracellular measurements. They are non-toxic, highly selective robust probes for ionic fluxes monitoring. A large-scale fabrication of ion optodes using a solvent displacement method...
Resource Type:: Dissertation
Full Text:: Submicron Optical Ion-Selective Sensors. Abstract approved: James D. Ingle, Jr. Ion

Theoretical and experimental factors affecting the accuracy and precision of atomic absorption measurements

Creator:: Bower, Nathan Wayne
Abstract:: A procedure for evaluating the precision of atomic absorption measurements is presented and applied to 21 elements under varying instrumental conditions. The experimental relative standard deviations (RSD's) in absorbance obtained from repetitive measurements made with a high resolution voltmeter and on-line computer, are compared to those predicted by a recently...
Resource Type:: Dissertation
Full Text:: conditions 52 Noise sources 83 Introduction 83 E ' and a ' (0% T' noises) 84 ot ot E and a (0

Synthesis of epothilones and epothilone analogues

Creator:: Sundermann, Kurt F.
Abstract:: A convergent synthesis of epothilone B that generates all seven of its asymmetric centers in a completely stereoselective fashion has been completed. Key reactions include an anti-Felkin aldol condensation to set the C6 and C7 stereochemistry, a directed α-hydroxylation to install the C15 (S)-hydroxyl substituent, and a Wittig condensation to...
Resource Type:: Dissertation
Full Text:: sincere appreciation to Dr. Richard G. Carter, Dr. Duncan J. Wardrop, and Professor James, D White for

Applications of redox indicators for evaluating redox conditions in environmental samples

Creator:: Jones, Brian Dion
Resource Type:: Dissertation
Full Text:: Evaluating Redox Conditions in Environmental Samples Abstract approved: James D. Ingle, Jr. Redox sensors

The synthesis of trisporic acids

Creator:: Prisbylla, Michael Paul
Abstract:: A total synthesis of the fungal hormones, trisporic acids A and B, is described, starting from a -methyltetronic acid 34. A Robinson annelation of 34 with ethyl vinyl ketone affords the lactone 33. Treatment of 33 with N-bromosuccinimide gave 97, which was hydrolyzed to the lactol 103. The reaction of...
Resource Type:: Dissertation
Full Text:: 13, 1977 Title: THE SYNTHESIS OF TRISPORIC ACIDS Abstract approved: Redacted for Privacy Dr. James

Approaches to the synthesis of penicillin

Creator:: Furuta, Takuya
Abstract:: Several approaches to the synthesis of penicillin from 2-iminothioazolidine 50, from 2-thiothiazolidine 66 and by photocyclization of 77 and 78 were investigated. 2-Iminothiazolidine 50 was prepared from dibromoester 45 by the action of benzylamine followed by treatment of aziridine 46 with potassium or ammonium thiocyanate. Attempted introduction of a two-carbon...
Resource Type:: Dissertation
Full Text:: . James D. White Several approaches to the synthesis of penicillin from 2-imino- thioazolidine 50, from

Intramolecular diels-alder cycloadditions of citraconic and mesaconic esters ; Studies on the synthesis of the northwest and southeast segments of boromycin

Creator:: Sheldon, Bernard Gale
Resource Type:: Dissertation
Full Text:: BOROMYCIN Redacted for privacyAbstract approved: Dr. James D. White The thermal cycloaddition of trans

Polarographic investigation of niobium and tantalum with special reference to the niobium-phosphate system

Creator:: Clauss, James Kilbourn
Resource Type:: Dissertation
Full Text:: ~ Harry Freund for his counsel and direction during the course of this work, and also Messers James

Development of automated flow injection apparatus and a novel flow cell for chemi- and bioluminescence determinations

Creator:: Gander, Stuart C.
Abstract:: A practical and versatile instrument has been developed both to optimize the chemistry of bio- and chemiluminescence reactions and to measure ultra-trace quantities of associated analytes. The instrument consists of a pneumatic flow injection system linked to a detection cell and a signal processing and readout system. The disk-like cell...
Resource Type:: Masters Thesis
Full Text:: Determinations . Redacted for Privacy Abstract approved: Dr. James D. Ingle, Jr. A practical and versatile

Part I. The total synthesis of (±)-cinnamodial and related drimane sesquiterpenes; Part II. Photochemical activation of the carboxyl group via N-Acyl-2-thionothiazolidines

Creator:: Burton, Lester Percy Joseph
Resource Type:: Dissertation
Full Text:: NAcy1-2-thionothiazolidines Abstract approved: Redacted for privacy DT. James D. White Part I A total

Synthetic studies on natural products : Part I. The total synthesis of ±-euonyminol and ±-3,4-dideoxymaytol : Part II. The absolute configuration and enantioselective synthesis of curacin A

Creator:: Kim, Tae-Seong
Resource Type:: Dissertation
Full Text:: . The Total if _ -E in min 4-13- m. 1 P rt II. Th- A of to Configuration and Enantioselective

Condensation of crotonic and tiglic acids with aldehydes and ketones

Creator:: Johnson, Paul Robert
Resource Type:: Masters Thesis
Full Text:: and Ketones Abstract approved: Redacted for Privacy James D. White 3,3-Dimethoxy-2,2

The total synthesis of (-)- acorenone B ; Approaches to the synthesis of mycosporin (P 310)

Creator:: Ruppert, John Fredrick
Resource Type:: Dissertation
Full Text:: : Redacted for Privacy Dr, James D. White An improved technique for synthesis of p-hydroxy esters via the

An approach toward the synthesis of euonyminol and cathedulin K- 19

Creator:: Shin, Hyunik
Abstract:: A synthetic approach toward the two major fragments of cathedulin K-19, euonyminol (4) and dimethyl cathate (69), was investigated. Synthesis of dimethyl cathate was accomplished in 3 steps starting from 73. Efforts directed towards the synthesis of euonyminol, a highly oxygenated dihydroagarofuran sesquiterpene, was advanced to a stage in which...
Resource Type:: Dissertation
Full Text:: , Chaehee, and Jaesoon Acknowledgements I would like to sincerely thank professor James D. White for the

Chiral synthesis of alcohols via asymmetric epoxidation

Creator:: Engebrecht, Jeffrey Ronald
Abstract:: Enantioselective epoxidation of crotyl alcohol, followed by a cuprate mediated methylation, gave a 1:1 mixture of (2S) -3- methyl -1,2- butanediol and (2R,3S)-2-methy1-1,3- butanediol. The latter was separated as its 2,4,6-trimethylbenzenesulfonate derivative and converted via the iodide to the corresponding phosphonium salt. The separated butanediol derivatives were independently transformed to...
Resource Type:: Masters Thesis
Full Text:: approved: Redacted for privacy Dr. James D. White Enantioselective epoxidation of crotyl alcohol

The isolation and structure of leptosphaerin : a metabolite of the marine ascomycete, Leptosphaeria oraemaris (Linder) and A synthesis of the marine toxin, 9-isocyanopupukeanane

Creator:: Schiehser, Guy Alan
Abstract:: The ethyl acetate extract of the culture filtrate of the marine Ascomycete, Leptosphaeria oraemaris (Linder) yielded a novel metabolite designated by the common name leptosphaerin. An x-ray crystallographic structure analysis was disproved by the synthesis of 3-acetoxy-S-(1,2-dihydroxyethyl)- 3-pyrrolin-2-one 1, starting with N,N-dibenzylhydroxylamine 47 and D-mannitol 44. Oxidation of 47 followed...
Resource Type:: Dissertation
Full Text:: -ISOCYANOPUPUKEANANE Abstract approved: Redacted for Privacy U Dr. James D. White The ethyl acetate extract of the

Approaches to the synthesis of methymycin

Creator:: Raghavan, Palaykotai Rajagopalan
Abstract:: Several approaches to the synthesis of methymycin were investigated. Segment A (39), containing functionality corresponding to C-9, 10, and 11 of methynolide was made in six steps from propionaldehyde in an overall yield of 37%. Oxidation of 34 with silver nitrate gave 35 which, upon hydroxylation with hydrogen peroxide, gave...
Resource Type:: Dissertation
Full Text:: approved: Dr. James D. White Several approaches to the synthesis of methymycin were investigated

Cyclization of olefinic β-ketoesters. An approach to the synthesis of aplysistatin

Creator:: Skeean, Richard William
Resource Type:: Dissertation
Full Text:: . An Approach to the Synthesis of Aplysistatin Abstract Approved: Redacted for privacy 7/ Dr. James D

Part I : development and application of an arsenic speciation technique using ion-exchange solid phase extraction coupled with GFAAS ; Part II : investigation of zinc amalgam as a reductant

Creator:: Bos, Mark C.
Abstract:: Two related techniques, based upon ion-exchange solid phase extraction, have been developed for the determination of arsenic speciation. The inorganic arsenic species arsenite (As(III)) and arsenate (As(V)) are separated by anion-exchange and detected with graphite furnace atomic absorption spectrophotometry (GFAAS) with a nickel matrix modifier. The first separation technique, which...
Resource Type:: Masters Thesis
Full Text:: Amalgam as a Reductant Abstract approved: James D. Ingle Jr. Two related techniques, based upon ion

Alkylation studies on Hagemann's ester: an approach to the synthesis of the trisporic acids

Creator:: Sung, Wing Lam
Abstract:: Sequential alkylation of Hagemann's ester with methyl and methallyl halides has been studied. Treatment of Hagemann's ester with methyl iodide and sodium ethoxide gave a mixture of 21 and 25 in a ratio of 4:1. Alkylation of 21 with methallyl chloride and potassium t-butoxide afforded a mixture of 37 and...
Resource Type:: Masters Thesis
Full Text:: Privacy James D. White Sequential alkylation of Hagemann's ester with methyl and methallyl halides has

Simple models for the structure and dynamics of polyatomic fluids

Creator:: James, Corinne Patricia
Abstract:: Three areas of liquid state theory are considered. First, Monte Carlo computer simulation of a two-dimensional hard disk fluid with an imbedded ellipse was undertaken to determine how a non-spherical molecule affects intermolecular ordering. The elliptical molecule (with axial ratios of 2, 5 and 10) altered the isotropic distribution of...
Resource Type:: Dissertation
Full Text:: Fluids AN ABSTRACT OF THE THESIS OF Corinne Patricia James for the degree of Doctor of Philosophy in

Studies toward the total synthesis of phorboxazole A

Creator:: Kuntiyong, Punlop
Abstract:: Studies toward the total synthesis of a highly potent cytotoxic marine natural product, phorboxazole A, were conducted and resulted in a route to an advanced intermediate, C4-C32, for this purpose. A key feature of our approach is the stereoselective synthesis of two cis-2,6-disubstituted tetrahydropyrans present in the macrolide portion of...
Resource Type:: Dissertation
Full Text:: TOTAL SYNTHESIS OF PHORBOXAZOLE A. Abstract approved: James D. White Studies toward the total

Studies of ammonia gas transport and fluorimetric detection in an aqueous solution

Creator:: Clark, Eric J.
Resource Type:: Masters Thesis
Full Text:: intermediates or products are produced (A B C - D), with one side reaction (C E), two of which are proposed to

Formation of sulfenato and sulfinato cobalt (III) complexes by the oxidation of coordinated cysteine

Creator:: Sloan, Camilla Peel
Resource Type:: Masters Thesis
Full Text:: is presented .e/ajyy%4.1v IS; 171 Typed by Opal Grossnicklaus for Camilla Peel Sloan

Kinetics of F-center aggregate formation

Creator:: Paul, James Leonard
Resource Type:: Dissertation
Full Text:: AN ABSTRACT OF THE THESIS OF JAMES LEONARD PAUL for the

Studies of chemical speciation of trace metals in natural waters using an on-line electrochemical cell and ion exchange system

Creator:: Sule, Pushkar Anant
Resource Type:: Masters Thesis
Full Text:: and Ion Exchange System Abstract approved: Redacted for privacy James D. Ingle, Jr. A flow-through

Studies on the synthesis of the "northern" and "southern" segments of boromycin and aplasmomycin

Creator:: Kang, Myung Chol
Abstract:: The stereocontrolled synthesis of the southern lactone 17 of boromycin and of the northern segments of both boromycin and aplasmomycin are described. The syntheses begin with enantioselective epoxidation of 3-buten-2-ol (42) to provide the optically active 2(S),3(R) epoxy alcohol 43. The absolute configuration was confirmed by preparing 43 from (-)-2,3-dihydroxybutyric...
Resource Type:: Dissertation
Full Text:: for privacy Dt. James D. White The stereocontrolled synthesis of the southern lactone 17 of

The synthesis of nonactic acid

Creator:: Arco, Manuel Jose
Abstract:: Alkylation of propylene oxide with 2-lithiofuran gave alcohol I, which was smoothly converted to acetylfuran II. hydrogenation of II over rhodium on charcoal followed by Jones' oxidation afforded ketone III. Further transformation into IV was accomplished via a Wittig reaction followed by saponification with methanolic sodium hydroxide. Hydroboration of the...
Resource Type:: Dissertation
Full Text:: NONACTIC ACID Abstract approved: Redacted for privacy I James D. White Alkylation of propylene oxide

Approaches to the synthesis of polyketides. Vermiculine

Creator:: Kirkemo, Curtis Lee
Abstract:: An approach to the generation of polyketides was investigated, which involved ozonolysis of 6, 7 cyclopenteno -1> 4, 5, 8 -tetrahydromethoxy- 3-methylnaphthalene (26), to produce what is believed to be polyketide 27. Compound 26 was formed by the following sequence: Die ls -Alder addition of 1, 2 -dim.ethylenecyclopentane and 2...
Resource Type:: Dissertation
Full Text:: SYNTHESIS OF POLYKETIDES. VERMICULINE. Redacted for privacy Abstract approved: Dr. James D. White An

Structural and synthetic studies of higher terpenoids : Part I. The absolute configuration of (-)-botryococcene : Part II. Total synthesis of (±)-2-desoxystemodinone

Creator:: Somers, Todd Charles
Resource Type:: Dissertation
Full Text:: . Redacted for Privacy Abstract approved: U James 0. White Part I. Complete structural and stereochemical

A Mossbauer effect investigation of the magnetic hyperfine structure in bis (morpholyl-dithiocarbamato) iron (III) halides

Creator:: Grow, James Michael
Resource Type:: Dissertation
Full Text:: Clover Redfern for James Michael Grow ACKNOWLEDGMENTS I wish to thank tl..e following people for

Tandem intramolecular photocycloaddition-retro-Mannich fragmentation as a route to indole and oxindole

Creator:: Li, Yang
Abstract:: Irradiation of a tryptamine linked through its side-chain nitrogen to an alkylidene malonate residue results in an intramolecular [2 + 2] cycloaddition to the indole 2,3-double bond. The resultant cyclobutane undergoes spontaneous retro-Mannich fission to produce a spiro[indoline-3,3-pyrrolenine] with relative configuration defined by the orientation of substituents in the transient...
Resource Type:: Dissertation
Full Text:: approved: James D. White

Continuous sample flow and mercury (II) speciation studies utilizing the cold vapor atomic absorption method for mercury determination

Creator:: Oda, Carl Ekio
Resource Type:: Masters Thesis
Full Text:: for Mercury Determination Redacted for Privacy Abstract approved: James D. Ingle, Jr., Associate

Total synthesis of (+)-bourgeanic acid and conformational analysis of its dilactone

Creator:: Johnson, Alan T. (Alan Thomas), 1957-
Resource Type:: Dissertation
Full Text:: Conformational Analysis of its Dilactone Abstract approved: _Redacted for Privacyj James u. wnite The total

Ion pairing of nucleotides with surfactants for enhanced sensitivity in liquid matrix assisted secondary ion mass spectrometry

Creator:: Pavlovich, James Gilbert
Abstract:: In particle induced desorption-ionization mass spectrometry the strength of an analyte's signal under a given set of bombardment conditions is usually considered to be representative of the analytes relative surface activity. This rationale is generally used to explain differences in the technique's sensitivity between and within various classes of compound....
Resource Type:: Dissertation
Full Text:: sensitivity in liquid matrix assisted secondary ion mass spectrometry AN ABSTRACT OF THE THESIS James

The synthesis of macrolactones from [omega]-hydroxyacyl xanthates

Creator:: Akella, Annapoorna
Resource Type:: Masters Thesis
Full Text:: Xanthates Redacted for Privacy Abstract approved: James D. White The synthesis of macrolactones from 0

Approaches toward the asymmetric synthesis of pillaromycin A

Creator:: Nolen, Ernest G.
Resource Type:: Dissertation
Full Text:: A. Abstract approved: Redacted for Privacy ()James D. White Pillaromycin A, an antibiotic natural

The structure and thermodynamic properties of 2-bromoethanol as determined by gas phase electron diffraction

Creator:: English, James Roger
Resource Type:: Masters Thesis
Full Text:: AN ABSTRACT OF THE THESIS OF JAMES ROGER ENGLISH for the

Development of chemostats and use of redox indicators for studying redox transformations in biogeochemical matrices

Creator:: Lemmon, Teresa L.
Resource Type:: Dissertation
Full Text:: Matrices. Abstract approved. James D. Ingle Jr. Two sophisticated reactor systems were developed for

Total synthesis of indole alkaloids: pt. 1. Asymmetric synthesis of (-)-ibogamine. pt. 2. An approach toward the synthesis of koumine

Creator:: Choi, Younggi
Abstract:: PART I. The preparation of (-)-ibogamine (1) in fourteen steps from benzoquinone and in 10% overall yield is a powerful illustration of the value of the asymmetric Diels-Alder reaction as a starting point in a multistep synthesis. All four cycloadducts, 70, 77, 84 and 96, obtained with the (S)-BINOL-TiCl₂ complex...
Resource Type:: Dissertation
Full Text:: SYNTHESIS OF KOUMINE. Abstracted approved: James D. White PART I. The preparation of ()-ibogamine (1) in

Approaches toward synthesis of the mycosporins

Creator:: Cammack, Janice H.
Abstract:: The mycosporins, formerly called P310's are secondary metabolites of fungi closely associated with fungal reproductive processes that require light. The structurally related iminomycosporins are found in marine plants and animals and may also have functions related to light. In this study, approaches toward the asymmetric synthesis of the mycosporins are...
Resource Type:: Dissertation
Full Text:: . James D. White Abstract approved: The mycosporins, formerly called P310's are secondary metabolites

Studies toward the total synthesis of (+)-providencin

Creator:: Jana, Somnath
Abstract:: Studies toward the total synthesis of (+)-providencin (1), a highly oxygenated cembranoid dipterpene with a unique bicyclo[12.2.0]hexadecane skeleton and pronounced biological activity, are described. These studies resulted in the synthesis of advanced intermediates 320 and 332 which contain all of the carbon atoms of 1. In a first generation approach...
Resource Type:: Dissertation
Full Text:: approved: _____________________________________________________ James D. White Studies toward

Microcomputer-based fluorometric kinetic determination of ascorbic acid and flow injection analysis methods for interference correction and kinetic determinations based on the peak profile

Creator:: Chung, Hyung-Keun
Resource Type:: Dissertation
Full Text:: . 1968, 17. S. R. Crouch, Anal. Chem. 1969, 41, 880 18. G. E. James and H. L. Pardue, Anal. Chem. 1969

A kinetic investigation of the mechanism and intermediates of the chromium(VI)-Iodide reaction

Creator:: Gaswick, Dennis Charles
Resource Type:: Dissertation
Full Text:: for Privacy Abstract approved: James Krueger (s) The kinetics of the reaction between HCrO4 and I in

A microcomputer automated anodic stripping voltammetric analyzer for trace heavy metal speciation

Creator:: Dewald, Lamar Robert
Abstract:: An automated instrument based on a single-board microcomputer was developed for use in voltammetric analyses. Operator input of numerous experiment parameters allows any type of voltammetric analysis to be implemented and multiple scans to be run unattended. A three operational amplifier potentiostat is used to control the cell voltage and...
Resource Type:: Dissertation
Full Text:: attainment of equilibrium after spiking seawater samples with metal ions. Similiar experiments e (109

A U.V. spectrophotometric study of the kinetics of some nucleophilic displacement reactions involving hydroxylamine-O-sulfonate ion

Creator:: Lee, Albert Punpong
Resource Type:: Masters Thesis
Full Text:: I wish to express my appreciation to Dr. James H. Krueger fo- his guidance throughout this study

Development of automated on-line ion exchange systems for the determination of chemical speciation of trace metals in natural waters

Creator:: Liu, Yan
Abstract:: An automated on-line ion exchange trace enrichment system has been developed to improve the detection limits of flame atomic absorption (AA) spectrophotometry in the determination of trace metals in natural waters. The sample solution is passed through a column of Chelex-100 chelating resin by a carrier buffer stream delivered from...
Resource Type:: Dissertation
Full Text:: Speciation of Trace Metals in Natural Waters Abstract approved : Redacted for privacy James D. Ingle, Jr

Kinetics and mechanisms of displacement reactions involving trithionate ion

Creator:: Ritter, Ronald Dale
Resource Type:: Dissertation
Full Text:: (basicity). (6) log k/k0 = aEn + PH Here (k /k ) is the rate relative to water, E is the standard

The development and characterization of miniature spectrometers for measuring the redox status of environmental samples

Creator:: Cantrell, Kevin
Abstract:: A spectrometer, here denoted a Simple, Low-power, Inexpensive. Microcontroller-based or SLIM spectrometer. was developed that exploits the small size and low cost of solid-state electronic devices. This approach results in customizable spectrometers that are considerably less expensive and smaller than traditional instrumentation. The performance of the SLIM spectrometer was evaluated...
Resource Type:: Dissertation
Full Text:: approved: James D. Ingle, Jr. A spectrometer, here denoted a Simple, Low-power, Inexpensive

Natural product synthesis via cyclobutanes : part I, Asymmetric synthesis of (+)-byssochlamic acid, part II, An approach to the nootropic agent huperzine A

Creator:: Kim, Jungchul
Abstract:: PART I. Asymmetric syntheses of both natural (+)- and nonnatural (-)-byssochlamic acid via a [2+2] photoaddition-cycloreversion strategy are described. X-ray crystallographic analysis of the cyclohexylamine salt 99 showed that the structure of the monomethyl ester 100 from esterase hydrolysis of 44 was originally misassigned as 56. The enantiomeric relationship of...
Resource Type:: Dissertation
Full Text:: approved: James D. White PART I. Asymmetric syntheses of both natural (+)- and nonnatural

Nuclear magnetic resonance investigation of acidic proton behavior in phenylsulfonylacetone and acetohydroxamic acid

Creator:: Stanclift, William Everett
Resource Type:: Masters Thesis
Full Text:: gratefully acknowledges the patient guidance and willi.ng assi.stan(:e of'Dr. Jarnes H. Krueger in preparing

Partial chemical speciation techniques for aquatic humic-metal complexes

Creator:: Chase, Duane Scott
Resource Type:: Masters Thesis
Full Text:: Humic-Metal Complexes Abstract approved: Redacted for privacy James D. Ingle, Jr., Associate

Studies toward the total synthesis of sanglifehrin A

Creator:: Suttisintong, Khomson
Abstract:: Studies toward synthesis of subunits of sanglifehrin A, an immunosuppressant featuring a highly substituted [5,5]-spirolactam moiety as well as a 22-membered macrocycle are described. The macrolactone contains a peptidic backbone characterized by an unusual [beta]-substituted (S)-piperazic acid and (S)-m-hydroxyphenylalanine units. These studies resulted in the synthesis of advanced intermediate 358...
Resource Type:: Dissertation
Full Text:: :______________________________________________________ James D. White Studies

Synthesis of two subunits of avermectin B1a

Creator:: Dantanarayana, Anura Pathmasiri
Abstract:: Avermectins are a group of potent anthelmintic agents produced by Streptomyces avermitilis. They are active at extremely low dosages and are now in commercial use. In this study, the synthesis of two segments of avermectin B[subscript 1a] are described. The synthesis of the hexahydrobenzofuran subunit (segment A) began with the...
Resource Type:: Dissertation
Full Text:: approved: Redacted for privacy (it James D. White Avermectins are a group of potent anthelmintic agents

Oxidation of ethanol and phenols with permanganate for chemiluminescence analysis

Creator:: Al-Mutawah, Jameela Isa
Resource Type:: Masters Thesis
Full Text:: Permanganate for Chemiluminescence Analysis Abstract approved: James D. Ingle, Jr. This thesis is

A kinetic investigation of the hydrolysis of trimethylamine-sulfur trioxide in dimethyl sulfoxide-water solvents

Creator:: Johnson, William Allen
Resource Type:: Dissertation
Full Text:: ± 0.5 kcal/ mole and L S1$ _ -8 ± 1.4 e. u. Activation parameters for the second order hydrolysis

Phenolic oxidative coupling : an approach to the synthesis of pretazettine

Creator:: Chong, Wesley Kwan Mung
Abstract:: Various hypervalent iodine compounds were evaluated as reagents for intramolecular phenolic oxidative coupling. It was found that phenyliodine(III) bis(trifluoroacetate) was effective for the coupling of the monophenolic substrate 13a to 14a under neutral conditions. Vanadium oxytrifluoride and hypervalent iodine compounds were compared as oxidants for the conversion of 32 to...
Resource Type:: Dissertation
Full Text:: the Synthesis of Pretazettine. Redacted for Privacy Abstract approved: Di. James D. White Various

Microcomputer controlled chemical and radiochemical separations and analysis

Creator:: Bennett, Casey Wayne
Abstract:: An automated radiochemical flow analysis (ARFA) system was developed which integrates chemical and radiochemical techniques into one system through the use of a microcomputer. The operator, through the microcomputer, controls valves and pumps to transfer sample and reagent solutions to counting loops, ion exchange columns and holdup reservoirs. A Ge(Li)...
Resource Type:: Dissertation
Full Text:: Radiochemical Separations and Analysis Abstract approved: Redacted for Privacy James -D. Ingle, Jr

The effect of pressure and temperature upon the hydrogenation of California sardine oil

Creator:: Rave, William John
Resource Type:: Masters Thesis
Full Text:: C. Refractive Index D. Iodine Number E. Thiocyanogen Number '. Separation of Solid and Liquid

Fluoroboranes : I. Preparation and properties of trifluoromethyldi-n-butylborane : II. A study of doboron tetrafluoride

Creator:: Self, James Maurice
Abstract:: A large-scale preparative method for potassium di-n-butylborate in triethylamine solvent has been developed. The reaction of potassium di-n-butylborate I with trifluoromethyl iodide has been shown to yield trifluoromethyl di-n-butylborane and other products. Reaction of this substance with boron trifluoride gave trifluoromethyl boron difluoride. Reactions of diboron tetrafluoride, boron tribromide, and...
Resource Type:: Dissertation
Full Text:: Trifluoromethyldi-n-Butylborane. II. A Study of Diboron Tetrafluoride AN ABSTRACT OF THE THESIS OF James Maurice

A quantitative description of the silver/aqueous cyanide electrolyte interface and the effect of the interface on the rate of electrodeposition of silver

Creator:: Jewett, James Richard
Resource Type:: Dissertation
Full Text:: AN ABSTRACT OF THE THESIS OF James Richard Jewett for the

A ferrocyanide-ceriometric method for the determination of zinc in ores

Creator:: Clauss, James Kilbourn
Resource Type:: Masters Thesis
Full Text:: ..e-Ceriometric Deter- mination of Zinc in Ores.......... IIoclifiel 71arin Titration

Carbon dioxide fixation and biosynthesis of amino acids in yeast (Saccharomyces cerevisiae)

Creator:: Davis, James Wendell
Resource Type:: Dissertation
Full Text:: CONTENTS :i: NTRODUCTION . . ....... . . i X.ERIMi4NTAL . . . . . , . . . . . . . . . . e . a . . . . s

The chemistry of selected carbene and radical ion intermediates

Creator:: Pugh, James K.
Resource Type:: Dissertation
Full Text:: Intermediates AN ABSTRACT OF THE THESIS OF James K. Pugh for the degree of Doctor of Philosophy in Chemistry

The synthesis and valence isomerization of some para-substituted 1-phenyl-1,3,5-hexatrienes

Creator:: Platt, James LeGrande
Resource Type:: Dissertation
Full Text:: -substituted 1-phenyl-1,3,5-hexatrienes AN ABSTRACT OF THE THESIS OF JAMES LEGRAND PLATT, Jr. for the DOCTOR

Synthetic studies on necic acids of pyrrolizidine alkaloids

Creator:: Lee, Nadine Chauyi
Resource Type:: Dissertation
Full Text:: Alkaloids Abstract approved: James D. White An asymmetric synthesis of (+)-nemorensic acid (25) is

Fiber optic sensors and spectrometry for the detection of volatile gem-polyhalogenated hydrocarbons

Creator:: Louch, Jeff
Abstract:: A fiber optic fluorometer utilizing a double-fiber optic probe was constructed. The absolute fluorescence signal and effective collection efficiency are approximately one fifth those of typical cuvette fluorometers and agree with those predicted by theory. A quinine sulfate calibration curve shows linearity from a detection limit of 10 pg/mL to...
Resource Type:: Dissertation
Full Text:: Privacy James D. Ingle, Jr. A fiber optic fluorometer utilizing a double-fiber optic probe was

Synthesis and oxidation of cysteine- and penicillamine- containing Fe(III) and Co(III) complexes. Analogs for the active metal sites of the cysteine and cysteamine dioxygenases

Creator:: Miller, Krys J.
Abstract:: The first part of this thesis describes a study of the characteristics of oxidation of a 1:2 iron(III):thiolate system in methanolic solution and in water. This system was investigated as a potential analog for the cysteine- and cysteamine-dioxygenase catalyzed 0₂-oxidation of cysteine and cysteamine, respectively, to the corresponding sulfinic acids....
Resource Type:: Dissertation
Full Text:: extend my appreciation to Dean Regier, Department of Agricultural Chemistry and Dr. James White's group

Development of methodology and instrumentation for determination of chloroform in water

Creator:: Yang, Ying, 1969-
Resource Type:: Dissertation
Full Text:: the Determination of Chloroform in Water Abstract approved: James D. Ingle, Jr. Spectrophotometric

Part I : synthesis of azetidin-2-ones from pyrazolidin-3-ones ; Part II : synthesis of a subunit of the immunosuppressant FK-506

Creator:: Toske, Steven Gerald
Resource Type:: Dissertation
Full Text:: Immunosuppressant FK-506. Abstract approved: James D. White Part I. A new route for the preparation of azetidin-2

Design, construction and application of an instrument for simultaneous measurement of molecular fluorescence, absorbance and chemiluminescence

Creator:: Yappert, Marta Cecilia
Abstract:: An instrument was constructed to measure molecular fluorescence (FL) or chemiluminescence (CL) and absorbance (ABS) simultaneously. The lower, middle, and upper portions of the test solution are probed to obtain ABS, FL, and CL data. Optical fibers are used extensively. The ABS and FL or CL spectra are acquired in...
Resource Type:: Dissertation
Full Text:: Privacy James D. Ingle, Jr. ABSTRACT An instrument was constructed to measure molecular fluorescence

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