The rate of interaction of carbon dioxide with eight detached organic films commonly used as coatings for metal surfaces was examined.
The films studied were lacquers of several different formulations
including oleoresinous, phenolic, vinyl, alkyd, epoxy, and
hydrocarbon types. The sorption was measured on a McBain type
gravimetric adsorption balance...
Solid state luminescent sulfides are prepared as powders in order to elucidate the relationship between structure and light emission. While the sulfides studied in this dissertation are known phosphors, materials are investigated in a variety of new ways. Elementary properties and structures of MgS are reviewed, and preparation of MgS...
This thesis describes the development of a new enantioselective synthetic method employing chiral cis-2,5-diaminobicyclo[2.2.2]octane-based organometallic catalysts. The significance of this new method to organic synthesis is illustrated with preparation of enantioenriched products that are transformed to important pharmaceutical agents. Chapter 1 provides a brief historical overview of asymmetric catalysis, especially...
Three approaches toward the core of halichlorine and pinnaic acid are described. The first approach entails a racemic transannular nitrone-olefin [3+2] cycloaddition from nitrone 238. Construction of the nitrone 238 began with aldehyde 241. Another key feature in this route involved a ring-closing metathesis for the formation of a 14-membered...
Thermoelectric materials are playing a larger role in the global effort to
develop diverse, efficient, and sustainable energy technologies: primarily through
power-generating thermoelectric modules. The principal components of
thermoelectric modules are solid-state thermoelectric materials – typically heavily
doped semiconductors – that convert heat directly into electricity. However, this
conversion efficiency...
The purpose of this project was to study the reactions of 1-(α-pyridyl)-3-buten-1-ol (compound I) and to determine whether or
not the products of some of its reactions are quinolizinium salts.
Reaction of compound I with bromine or iodine yields halide
salts (when no external cooling is applied) instead of the...
New analytical methods and instrumentation were developed for the determination of dissolved oxygen (DO) at low concentrations in water. The methods were based on monitoring the absorbance increase due to the oxidation of reduced indigo carmine (IC) by oxygen in the sample in different types of spectrometer cells. Spectrophotometer cells...
Various hypervalent iodine compounds were evaluated as reagents
for intramolecular phenolic oxidative coupling. It was found that
phenyliodine(III) bis(trifluoroacetate) was effective for the coupling
of the monophenolic substrate 13a to 14a under neutral conditions.
Vanadium oxytrifluoride and hypervalent iodine compounds were compared
as oxidants for the conversion of 32 to...
Studies towards the total synthesis of (+)-Phomactin A (1), D (6), and G (9), fungal metabolites with unique molecular architecture and pronounced biological activity, are described. These studies resulted in the synthesis of advanced intermediates 354 and 356, which contain all of the carbon atoms of 1, 6 and 9....
New methods, sensors, and devices based on redox indicators were developed to
monitor redox conditions in anoxic and anaerobic laboratory systems and the subsurface
environment. The primary application was monitoring redox conditions
during the dechlorination of tetrachioroethene (PCE) to ethene (ETH) in packed
columns and microcosm bottles containing an enriched...
The total synthesis of a highly potent cytotoxic marine natural product, phorboxazole A, is described. Both a palladium(II)-mediated and a palladium(II)-catalyzed intramolecular alkoxycarbonylation were used as key steps for the preparation of the two cis-2,6-disubstituted tetrahydropyran rings (C22-C26 and C11-C15) of phorboxazole A.
The synthesis used a convergent approach involving...
Part I: Racemic and asymmetric syntheses of a new substance with prospective antidepressant properties were achieved. In vitro assays with synthetic racemates (±)-25 and (±)-26 suggested that the former is a relatively selective inhibitor of serotonin transporter whereas the latter is a more balanced inhibitor of both serotonin and norepinephrine...
The development and optimization of a fluorometric reaction
rate method for the determination of aluminum is described.
Modifications to existing instrumentation permit automatic
monitoring and reporting of measurement conditions. Automatic
correction of measured analytical signals is provided if monitored
parameters deviate from optimum values. A computer controlled
standard addition procedure...