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Advanced studies of blasticidin S biosynthesis

Creator:: Zhang, Qibo
Resource Type:: Dissertation
Full Text:: Advanced studies of blasticidin S biosynthesis AN ABSTRACT

Advanced Mass Spectrometry Techniques for Characterizations of Proteome and Lipidome Profiles of Osteosarcoma Cells

Creator:: Song, Zifeng
Abstract:: Mass Spectrometry has emerged as an analytical core technique in omics sciences, in particularly mass spectrometry has advanced the fields of proteomics, metabolomics and lipidomics in recent years. Mass spectrometric techniques have enabled the characterization and determination of abundance levels of a wide range of biomolecules at molecular and system-wide...
Resource Type:: Dissertation
Full Text:: degree of Doctor of Philosophy in Chemistry presented on October 17, 2018. Title: Advanced Mass

The Role of Materials Chemistry in Designing Advanced Color Inorganic Pigments

Creator:: Medina, Elena A.
Abstract:: The results of the research presented in this work are related to synthesis and investigations of novel color inorganic pigments having various structures and shades. Inorganic pigments play a major role in contemporary life. They are used in paints, rubber, plastic, cosmetics etc. Searching for new, stable, environmentally benign and...
Resource Type:: Dissertation
Full Text:: Advanced Color Inorganic Pigments. Abstract approved

Advanced studies on the biosynthesis of the streptolidine moiety of streptothricin F

Creator:: Jackson, Michael D.
Resource Type:: Dissertation
Full Text:: Advanced Studies on the Biosynthesis of the Streptolidine

Studies of heavy element multi-nucleon transfer reactions using radioactive decay analysis of the 136Xe + 198Pt reaction at a center of target lab energy of 777 MeV (5.7MeV/A)

Creator:: McCaleb, Kyle M.
Abstract:: Recent experiments have advanced the current understanding of multi-nucleon transfer(MNT) reactions. Within nuclear science, most nuclear reaction experiments consist of a stationary target material, that is then bombarded by a moving projectile. Overall nuclear reactions can be used to produce a desired isotope. In the case of this particular study...
Resource Type:: Capstone Project
Full Text:: Master’s of Science Department of Chemistry Division of

A stereochemically controlled approach to the morphine alkaloids: racemization of 8,9-benzo-4,5-dihydro-6,7-pyrido[4,3-d] oxanin-3(2H)-ones

Creator:: Runyan, Mark T.
Abstract:: A method for the control of absolute stereochemistry in morphine syntheses has been demonstrated by the resolution and efficient racemization of the advanced morphine precursor , 9-methoxy-3-methyl-5,6-dihydro-3H-benzofuro[3,2-e]isoquinoline- 7(7aH)-one, I. This was accomplished by the facile coversion of optically resolved I to its ring opened form, 5,6,7,8-tetrahydro-10-methoxy-3-methyl-7-oxo[1]benzoxonino[ 6,7-c]pyridinium tosylate, II, (Equation...
Resource Type:: Masters Thesis
Full Text:: THESIS OF Mark T. Runyan for the degree of Master of Science in Chemistry presented on September 4

Synthetic studies of nonadrides

Creator:: Drapela, Nicholas Ernest
Abstract:: An asymmetric approach to the synthesis of byssochlamic acid (1) is described. Regioisomeric enzymatic differentiation is described in the selective hydrolysis of dimethyl ester 30 by porcine liver esterase. Chiral dimethyl ester 42 was prepared by desymmetrization of cyclopentene 34 using porcine liver esterase. A key intramolecular [2+2]cycloaddition-cycloreversion photometathesis of...
Resource Type:: Dissertation
Full Text:: intramolecular [2+2]cycloaddition-cycloreversion photometathesis of diolide 69 was unsuccessful. An advanced

Synthesis of furanoeremophilane sesquiterpenoids

Creator:: Shanmugham, Meenakshi Sundaram
Abstract:: Two approaches to the tricyclic core of the furanoeremophilane sesquiterpenoids are described. The first approach entails a projected Diels-Alder/retro Diels-Alder reaction of an acetylenic oxazole 64. Construction of the pivotal aldehyde 67 commenced from ketone 68. The acetyenic moiety was then introduced via a Felkin-Ahn addition of lithiopropyne to aldehyde...
Resource Type:: Dissertation
Full Text:: approach exploited a new annulation strategy. The aldehyde 64 was advanced to the 2, 4, 6

Synthetic Studies towards Highly Oxygenated Furanyl Diterpenoids

Creator:: Goswami, Subir
Abstract:: The furanyl diterpenoid family of natural products has drawn the attention of both synthetic organic chemists and pharmacologists due to their complex structural architectures and diverse biological activity. Among them, wortmannin has been most extensively studied for biological activities. All these furanyl diterpenoids consist of a highly strained naptha[1,8-bc]furan core,...
Resource Type:: Dissertation
Full Text:: and wortmannolone has been developed. The key steps involved in the synthesis of advanced aldehyde

Part I: Synthesis and evaluation of synosutine as an inhibitor of serotonin, norepinephrine, and dopamine transporters Part II: Asymmetric approach to the tetracyclic core of neomangicol A

Creator:: Juniku, Rajan B.
Abstract:: Part I: Racemic and asymmetric syntheses of a new substance with prospective antidepressant properties were achieved. In vitro assays with synthetic racemates (±)-25 and (±)-26 suggested that the former is a relatively selective inhibitor of serotonin transporter whereas the latter is a more balanced inhibitor of both serotonin and norepinephrine...
Resource Type:: Dissertation
Full Text:: studies towards the tetracyclic core structure of neomangicol A (129) led to advanced intermediate 245

ScholarsArchive@OSU

Advanced studies of blasticidin S biosynthesis

Advanced Mass Spectrometry Techniques for Characterizations of Proteome and Lipidome Profiles of Osteosarcoma Cells

The Role of Materials Chemistry in Designing Advanced Color Inorganic Pigments

Advanced studies on the biosynthesis of the streptolidine moiety of streptothricin F

Studies of heavy element multi-nucleon transfer reactions using radioactive decay analysis of the 136Xe + 198Pt reaction at a center of target lab energy of 777 MeV (5.7MeV/A)

A stereochemically controlled approach to the morphine alkaloids: racemization of 8,9-benzo-4,5-dihydro-6,7-pyrido[4,3-d] oxanin-3(2H)-ones

Synthetic studies of nonadrides

Synthesis of furanoeremophilane sesquiterpenoids

Synthetic Studies towards Highly Oxygenated Furanyl Diterpenoids

Part I: Synthesis and evaluation of synosutine as an inhibitor of serotonin, norepinephrine, and dopamine transporters Part II: Asymmetric approach to the tetracyclic core of neomangicol A

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