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Filtering by: Subject DNA-protein interactions Remove constraint Subject: DNA-protein interactions Degree Field Chemistry Remove constraint Degree Field: Chemistry

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  • Mass spectrometric analysis of UV-crosslinked protein-nucleic acid complexes

    Creator:
    Doneanu, Catalin E.
    Abstract:
    The DNA-binding domains of E. coli uracil-DNA glycosylase (Ung) and human replication protein A (hRPA) were studied using a general protocol developed in our laboratory for probing protein-DNA interactions. The procedure involves purification and mass spectrometric analysis of the nucleopeptide-products of a tryptically digested UV-crosslinked protein-nucleic acid complex. In the...
    Resource Type:
    Dissertation
    Full Text:
    . INTRODUCTION 1.1. ANALYSIS OF PROTEIN-DNA INTERACTIONS The study of the interaction of proteins, whether they