The continued long-term use of fossil fuels as a primary energy source has resulted in dramatic increases in greenhouse gas emissions and the associated concerns of climate change and environmental pollution. A key strategy to circumvent these issues is a global shift away from fossil fuels toward renewable energy sources....
Aromatic heterocycles are core structural motifs in natural products, pharmaceuticals and biological polymers. Indoles, in particular, represent a significant subclass of aromatic heterocycles, both in terms of sheer numbers, but also in biological and pharmaceutical relevance. As such, new methodologies for the synthesis of indoles represent an important and continually...
Tacrolimus is an immunosuppressant drug approved by the FDA for the prevention of organ transplant rejection. However, the use of this drug is hindered by its narrow therapeutic window and extreme insolubility in water. Due to these properties, the currently used tacrolimus preparations must be administered once or twice daily...
Lycopodium alkaloids have generated enormous amounts of interest from the scientific community, both as synthetic targets and for their medicinal properties. Herein is described work towards a unifying approach to large segments of the Lycopodium family. An organocatalyzed intramolecular heteroatom Michael reaction method, for the construction of piperidine and piperizine...
The general theme of this dissertation is the development of new analytical sensors to quantitatively study biological and environmental samples in aqueous and non-aqueous environments. A platinum ultramicroelectrode (UME) and a unique carbon-based pH microprobe were used to design a new SECM-based electrochemical bioassay. The Pt UME was used to...
The melt intercalation of poly(ethylene oxide) (PEO) between layers of MoO₃ and MPS3 (M=Mn,Cd) is obtained by heating the ground mixture and LiₓMoO₃, KₓMn₁-ₓ/₂PS₃, or KCd₁-ₓ/₂PS₃. The products are characterized by powder X-ray diffraction (XRD). Below the melting temperature of PEO (66 °C), intercalation rates and yields are low. By...
Xanthohumol [XN, (E)-6´-methoxy-3´-(3-methylbuten-2-yl)-2´,4´,4´´-trihydroxychalcone], the principal prenylated chalcone from hops, and its 2,3-dihydro- (DXN) and O6-desmethyl-2,3-dihydro- (DDXN) congeners, are of potential utility for the amelioration of metabolic syndrome; however, their complex bioactivity profiles cannot be properly studied and understood without access to appropriately produced synthetic materials.
In the first part of...
It is the responsibility of humans, as environmental stewards, to monitor our impact on the environment so that efforts can be made to remediate the effects of our actions and change behaviors. To better understand our environmental footprint, sensitive and simple analytical methods are needed to quantify the contaminants that...
Hop cell wall material (CWM) extracted from hop leaves (hamulus lupulus) was
purified and characterized. The total sugar content, uronic acid content and
monosaccharide composition of the CWM were determined. Galacturonic acid is the
major component in the CWM. A mixture of unsaturated oligogalacturonides were
released from purified hop CWM...