As part of the continuing investigation of the thermal cis- 1, 3, 5-hexatriene to 1,3-cyclohexadiene rearrangement, four new trienes and a cross-conjugated pentaene have been prepared and their thermal reactions studied. A new route to the synthesis of highly substituted trienes has been developed. The synthesis of three of these...
Steroid organoboranes have been found to be useful synthetic
intermediates. Attempted pyrolyses, based on simple trialkylborane
cyclizations, have not yielded C-19 or C-18 functionalized steroids,
but have produced isomerized systems not otherwise available.
Thus, hydroboration of cholesterol followed by pyrolysis at
215° gives 31% of 2-cholestene-6α-ol and 49% of a...
Studies of the use of NADH as the monitored fluorophore for enzymatic fluorescence kinetic methods are discussed. Interference studies
for the detection of NADH and the adaptation and optimization of fluorescence kinetic measurements to four serum assays are also described.
A microcomputer-controlled flow injection analysis (FIA) system was
designed and...