Small molecule drugs have been instrumental in our fight against diseases, beginning when some of the earliest ancient cultures used plant remedies to treat illnesses. More recently, the skill of isolating and characterizing the active ingredients within bioactive plants and microbial extracts has led to the isolation and design of...
The reaction of certain purin-8-ols with phosphorus
oxychloride and N,N-diethylaniline are described.
9-Amino-6-chloropurin-8-ol monohydrate reacted with
phosphorus oxychloride and N, N-diethylaniline to yield
the phosphorus oxychloride adduct. Other purin-8-ols
were prepared and the production of analogs similar to
the previously mentioned adduct was attempted.
6-Chloropurin-8-ol and 6, 9-diaminopurin-8-ol hydrochloride
monohydrate...
Ethanolysis reactions were conducted on the flavonoids, such
as, catechin, quercetin and dihydroquercetin, and polymeric phenolic
components from conifer barks, such as, mountain hemlock phlobatannin
and Douglas-fir phlobaphene with the object of ascertaining
their chemical relationship. These reactions were carried out with
absolute ethanol in the presence of 2.5% hydrogen...