Due to a number of disadvantages associated with the use of antibodies as
affinity stationary phases, researchers have recently began to explore the use of RNA
and DNA aptamers for use as affinity stationary phases. These molecules have been
shown to be a viable choice for applications in many methods...
In situ reduction of hydrido-tris-(3,5-dimethylpyrazolyl)borato(trioxo) rhenium(V) with triphenylphosphine or triethylphosphite leads to a reactive rhenium(V) species that catalytically deoxygenates epoxides at 75-105°C. The reaction is stereospecific, except for trans- and cis-butene oxide which formed minor amounts of the opposite isomer. A variety of different functional groups were tolerated and even...
Three approaches toward the core of halichlorine and pinnaic acid are described. The first approach entails a racemic transannular nitrone-olefin [3+2] cycloaddition from nitrone 238. Construction of the nitrone 238 began with aldehyde 241. Another key feature in this route involved a ring-closing metathesis for the formation of a 14-membered...
The photohydrodebromination of brominated paracyclophanes was studied to
help elucidate the possible mechanistic pathways leading to product for
bromoarenes in general. Several brominated [2.2]paracyclophanes were studied to
determine the effect of substitution patterns on this reaction. [2.2]Paracyclophanes
were chosen for this study in order to investigate possible intramolecular excimer
formation...
A multielement spectrometer has been developed for the simultaneous determination of four elements by atomic absorption (AA) or atomic fluorescence (AF). The spectrometer is based on a multiple exit slit monochromator and uses a mirrored funnel to direct light from the various exit slits to a single photomultiplier. There are...
The method of gas-phase electron diffraction is a very useful tool for determining
the geometry of a molecule in the gas-phase to a high degree of accuracy. In this thesis,
the structures of tropone and tropolone, which are similar molecules that are both based
on a 7-carbon ring, were investigated...