The unique reaction between 4, 6-dimethoxy-5-nitropyrimidine
and methylhydrazine was investigated. The reaction product was
identified as 4-hydrazino-6-hydroxypyrimidine from (a) spectral
data, (b) by direct synthesis of the product via 4-chloro-6-hydroxypyrimidine
and hydrazine, and (c) by conversion of the product to
the known 4-amino-6-hydroxypyrimidine using Raney nickel. The
product was not...
Heavy alcohol consumption reduces peak bone mass in growing rodents and can lead to bone loss in both adult rats and humans. In contrast, moderate alcohol consumption appears to have a bone sparing effect in post-menopausal women. Alcohol has been reported to increase aromatase activity and influence estrogen receptor (ER)...
Studies towards the total synthesis of (+)-Phomactin A (1), D (6), and G (9), fungal metabolites with unique molecular architecture and pronounced biological activity, are described. These studies resulted in the synthesis of advanced intermediates 354 and 356, which contain all of the carbon atoms of 1, 6 and 9....
The rearrangement of a homoallyl cation to a cyclopropylcarbinyl cation is thought to play a role in the biogenesis of a variety of cyclopropane-containing natural products,¹ a hypothesis which has previously led to the design of successful biomimetic syntheses of several natural products.² The strategy underlying this approach to cyclopropane...