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Filtering by: Committee Member Thompson, M. Paul Remove constraint Committee Member: Thompson, M. Paul Degree Field Chemistry Remove constraint Degree Field: Chemistry

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  • A unified approach for the total synthesis of C₁₀-functionalyzed Lycopodium alkaloids

    Creator:
    Saha, Mrinmoy
    Abstract:
    Lycopodium alkaloids have shown widespread and noteworthy biological activity, consisting of over 250 known natural products. Moreover, their structural complexity and diversity have attracted considerable attention from numerous laboratories including our own. Recently, we have developed a unified approach that would provides access to numerous, previously unprepared C₁₀-functionalized lycopodium alkaloids....
    Resource Type:
    Dissertation
    Full Text:
    ) Nikonorow, M. Acta Polon. Pharm. 1939, 3, 23-56. (d) Ortega, M. G.; Agnese, A. M.; Cabrera, J. L

  • The development of aminal radicals for the synthesis of nitrogen-rich natural products

    Creator:
    Schiedler, David A.
    Abstract:
    Organic compounds which contain one or more nitrogen atoms are especially important as they are disproportionately represented among biologically active molecules. As a result, significant effort has been focused on the development of methods for the synthesis of nitrogenous molecules. We identified the aminal as an under-explored functional group. Despite...
    Resource Type:
    Dissertation
    Full Text:
    . Abstract approved: ______________________________________________________ Christopher M. Beaudry

  • Enantioselective Total Syntheses of Quinolizidine Lycopodium Alkaloid Cermizine D and Cytotoxic Marine Macrolide Mandelalide A

    Creator:
    Veerasamy, Nagarathanam
    Abstract:
    The enantioselective total synthesis of quinolizidine-containing natural product cermizine D and formal syntheses of senepodine G and cermizine C has been achieved. These natural products are members of the lycopodium alkaloids, which have attracted significant attention due to their exciting biological activities and the diverse structural scaffolds. Key steps in...
    Resource Type:
    Dissertation
    Full Text:
    .) THF, 60 °C; 3 M HCl in MeOH 98% N H Cl NaBH4, MeOH 99% N H (-)-Cermizine C (1.9) 1.1.1 1.1.3

  • Computational Investigation and Prediction of Mechanisms and Stereocontrol in Complex Organic Reactions

    Creator:
    Pattawong, Ommidala
    Abstract:
    Complex organic transformations, such as the addition of pyrrole to ketene using planar chiral organocatalyst (*PPY), the four-component anhydride- Manniach reactions, and the site-selective desymmetrization of meso-1,2-diol, are remarkable synthetic reactions that provide high yield and high selectivity. However, the exact mechanism and origins of stereocontrol for theses synthetic organic...
    Resource Type:
    Dissertation
    Full Text:
    the four representative DAEHs. Christopher M. Beaudry and Paul Ha-Yeon Cheong contributed in part to

  • Exploratory Studies Within the Exotic Lyonsite Structure

    Creator:
    Tang, Joseph N.
    Abstract:
    Structure-property relationships have always underpinned the field of solid state chemistry; dependable structural descriptions are integral to understanding and controlling the physical properties of inorganic compounds old and new. While a handful of crystal structures are celebrated for their versatility, flexibility, and functionality, the existence of more exotic structures is...
    Resource Type:
    Dissertation
    Full Text:
    uphold that standard in my future scientific endeavors. I would like to thank Drs. Michael Lerner, Paul

  • Synthetic studies toward the total synthesis of azaspiracid-1

    Creator:
    Su, Dong
    Abstract:
    Azaspiracid-1, a novel marine toxin that contains 9 rings and 20 stereogenic centers, has drawn considerable attention from synthetic groups worldwide due to its structural complexity, which includes a unique trioxabisspiroketal fused to a tetrahydrofuran ring (ABCD rings), a piperidine-tetrahydrofuran spiroaminal system fused to a 2,9-dioxabicyclo[3.3.1]nonane system (FGHI rings), a...
    Resource Type:
    Masters Thesis