Studies toward the total syntheses of highly potent cytotoxic alkaloids
including the bromopyrrole alkaloids and indole alkaloids were conducted and are
described. Studies carried out in the course of this dissertation consist of five total syntheses of natural products that include bromopyrrole alkaloids nagelamide A, D and agelastatin D as...
Two studies were conducted involving rare earth elements. In the
first study, the use of rare earth diethylenetriaminepentaacetic acid
(DTPA) complexes as stable actiable tracers, a method of stable-isotope
tracing with post-sampling neutron activation analysis, was explored.
The persistence of rare earth DTPA complexes in estuarine waters was
measured in...
Part 1
The concentration of seventeen elements in two species of fungus
which cause wheat bunt disease, Tilletia caries (DC.)Tul. (TS) and
Tilletia controversa Kiihn (DS), were determined by instrumental neutron
activation analysis in 37 TS spore samples, and 31 DS spore samples.
Aluminum was chosen as a soil contamination...
Perdeutero-spiropentane (C₅D₈) has been synthesized and infrared and Raman spectra are reported for the first time. Wavenumber assignments are made for most of the fundamental vibrational modes. Gas phase infrared spectra were recorded at a resolution (0.002 cm⁻¹) sufficient to resolve individual rovibrational lines and show evidence of strong Coriolis...
The enantioselective total synthesis of quinolizidine-containing natural product cermizine D and formal syntheses of senepodine G and cermizine C has been achieved. These natural products are members of the lycopodium alkaloids, which have attracted significant attention due to their exciting biological activities and the diverse structural scaffolds. Key steps in...