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Biosynthesis of blasticidin S : mechanistic and stereochemical investigations

Creator:: Prabhakaran, P. C.
Abstract:: Feeding of [3-¹³C, 2-¹⁵N]arginine, 38a, unequivocally established that the β- arginine moiety of blasticidin S, 1, was formed from α-arginine by an intramolecular migration of the α-amino group to the β- position. Further feedings using chirally deuteriated arginines 38e and 38f revealed that the aminomutase process occurred with inversion of...
Resource Type:: Dissertation
Full Text:: . griseochromogenes have not been successful so far. Feeding [2,3,4,6,6- 2H5] -D- glucose resulted in blasticidin S

Design of a chemiluminescence photometer and its application to trace chromium (III) analysis

Creator:: Hoyt, Steven D.
Abstract:: The design and construction of a chemiluminescence photometer is described. The design is based on a discrete sample system which has a number of advantages over the previously described flow cell system and centrifugal analyzer. The advantages include simple and inexpensive equipment, small sample size, versatile electronic readout system, and...
Resource Type:: Masters Thesis
Full Text:: major Redacted for Privacy Chairman of the D partment of Cheiiitry Redacted for Privacy Dean of

Part I : synthesis of azetidin-2-ones from pyrazolidin-3-ones ; Part II : synthesis of a subunit of the immunosuppressant FK-506

Creator:: Toske, Steven Gerald
Resource Type:: Dissertation
Full Text:: Steven G. Toske for the degree of Doctor of Philosophy in Chemistry presented on June 10. 1993. Title

Purification of 2,5-dihydroxyacetanilide epoxidase and mechanism of hydroquinone epoxidases

Creator:: Kirchmeier, Marc J.
Abstract:: 2,5-dihydroxyacetanilide epoxidase from Streptomyces LL-C10037 (DHAE I) catalyzes the epoxidation of hydroquinone 4, to form epoxyquinone 7. DHAE I has been purified to homogeneity, with an overall purification factor greater than 23,000. N-terminal and internal amino acid sequences have been obtained from the purified enzyme so that the epoxidase gene...
Resource Type:: Dissertation
Full Text:: -dihydroxyacetanilide Epoxidase and the Mechanism of Hydroquinone Epoxidases Abstract approved: Steven J7Gould 2,5

LL-C10037α and MM 14201 : structure, biosynthesis and enzymology of two epoxysemiquinone antibiotics

Creator:: Shen, Ben
Resource Type:: Dissertation
Full Text:: approved: Ur. Steven J. Gould Antibiotic LL-C10037a, has now been shown to have the epoxysemiquinone

Studies on the biosynthesis of the streptolidine moiety of streptothricin F

Creator:: Wityak, John
Abstract:: The loss of all deuterium labels from previous feedings of [2-²H]-, [3,3-²H₂]-, and [2,3,3-²H₃]arginines had indicated the possible intermediacy of β-hydroxy- and β-ketoarginine (30 and 31, respectively) in the biosynthesis of the streptolidine portion of streptothricin F (la). In order to confirm or refute this evidence, D,L-[2,3,3,5,5-²H₅]- arginine (32) was...
Resource Type:: Dissertation
Full Text:: streptolidine portion of streptothricin F (la). In order to confirm or refute this evidence, D ,L- [2,3,3 ,5 ,5

Studies on advanced intermediates in the biosynthesis of streptonigrin

Creator:: Erickson, W. Randal
Abstract:: Early studies on the biosynthesis of the quinoline quinone portion of streptonigrin, 1, had suggested the intermediacy of novel aromatic amino acids. In order to test this hypothesis, a series of compounds was synthesized and tested for potential incorporation. [4-¹⁵N] 4-Aminoanthranilic acid, 4 5 a , [4-² H] 7-aminoquinaldinic acid,...
Resource Type:: Dissertation
Full Text:: Streptonigrin Abstract Approved: Redacted for privacy -Dr. Steven J. Gould Early studies on the biosynthesis

Advances in solid phase synthesis of neutral oligonucleotide analogues

Creator:: Wang, Haiyan, 1963-
Abstract:: A novel acyl protecting group for cytosine and adenine has been prepared from 4-( chloromethyl) benzoic acid. Reaction of the acid with morpholine produces 4-( 4-morpholinyl )methyl benzoic acid which is converted to it's acid chloride with thionyl chloride. This may be used to acylate cytidine and adenosine under standard...
Resource Type:: Masters Thesis
Full Text:: Oligonucleotide Analogues Redacted for Privacy Abstract approved: Dwight D. Weller A novel acyl protecting

Syntheses of labeled putative intermediates in acivicin biosynthesis

Creator:: Jiang, Nan
Resource Type:: Masters Thesis
Full Text:: ) generated in situ from paraformaldehyde and 2, 3- O- isopropylidene -5 -O- trityl -D- ribose -oxime (74

Advanced studies of blasticidin S biosynthesis

Creator:: Zhang, Qibo
Resource Type:: Dissertation
Full Text:: I am forever indebted to Professors Steven J. Gould and T. Mark Zabriskie whose friendships

ScholarsArchive@OSU

Biosynthesis of blasticidin S : mechanistic and stereochemical investigations

Design of a chemiluminescence photometer and its application to trace chromium (III) analysis

Part I : synthesis of azetidin-2-ones from pyrazolidin-3-ones ; Part II : synthesis of a subunit of the immunosuppressant FK-506

Purification of 2,5-dihydroxyacetanilide epoxidase and mechanism of hydroquinone epoxidases

LL-C10037α and MM 14201 : structure, biosynthesis and enzymology of two epoxysemiquinone antibiotics

Studies on the biosynthesis of the streptolidine moiety of streptothricin F

Studies on advanced intermediates in the biosynthesis of streptonigrin

Advances in solid phase synthesis of neutral oligonucleotide analogues

Syntheses of labeled putative intermediates in acivicin biosynthesis

Advanced studies of blasticidin S biosynthesis

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