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Filtering by: Subject Bacteriophage T4 Remove constraint Subject: Bacteriophage T4 Degree Field Genetics Remove constraint Degree Field: Genetics

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  • Mutagenic mechanisms associated with perturbations of DNA precursor biosynthesis in phage T4

    Creator:
    Ji, Jiuping
    Abstract:
    A crucial factor in determining the accuracy of DNA replication is maintenance of a balanced supply of deoxyribonucleoside triphosphates (dNTPs) at replication forks. Perturbation of dNTP biosynthesis can induce dNTP pool imbalance with deleterious genetic consequences, including increased mutagenesis, recombination, chromosomal abnormalities and cell death. Using the T4 bacteriophage system,...
    Resource Type:
    Dissertation
    Full Text:
    mutagenesis, recombination, chromosomal abnormalities and cell death. Using the T4 bacteriophage system, I